Recommanded Product: 3-Hydroxybenzaldehyde. I found the field of Biochemistry & Molecular Biology very interesting. Saw the article A drug discovery platform to identify compounds that inhibit EGFR triple mutants published in 2020.0, Reprint Addresses Stagljar, I (corresponding author), Univ Toronto, Donnelly Ctr, Toronto, ON, Canada.; Stagljar, I (corresponding author), Univ Toronto, Dept Mol Genet, Toronto, ON, Canada.; Stagljar, I (corresponding author), Univ Toronto, Dept Biochem, Toronto, ON, Canada.; Stagljar, I (corresponding author), Mediterranean Inst Life Sci, Split, Croatia.. The CAS is 100-83-4. Through research, I have a further understanding and discovery of 3-Hydroxybenzaldehyde.
Receptor tyrosine kinases (RTKs) are transmembrane receptors of great clinical interest due to their role in disease. Historically, therapeutics targeting RTKs have been identified using in vitro kinase assays. Due to frequent development of drug resistance, however, there is a need to identify more diverse compounds that inhibit mutated but not wild-type RTKs. Here, we describe MaMTH-DS (mammalian membrane two-hybrid drug screening), a live-cell platform for high-throughput identification of small molecules targeting functional protein-protein interactions of RTKs. We applied MaMTH-DS to an oncogenic epidermal growth factor receptor (EGFR) mutant resistant to the latest generation of clinically approved tyrosine kinase inhibitors (TKIs). We identified four mutant-specific compounds, including two that would not have been detected by conventional in vitro kinase assays. One of these targets mutant EGFR via a new mechanism of action, distinct from classical TKI inhibition. Our results demonstrate how MaMTH-DS is a powerful complement to traditional drug screening approaches.
Recommanded Product: 3-Hydroxybenzaldehyde. About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Saraon, P; Snider, J; Kalaidzidis, Y; Wybenga-Groot, LE; Weiss, K; Rai, A; Radulovich, N; Drecun, L; Vuckovic, N; Vucetic, A; Wong, V; Theriault, B; Pham, NA; Park, JH; Datti, A; Wang, J; Pathmanathan, S; Aboualizadeh, F; Lyakisheva, A; Yao, Z; Wang, YH; Joseph, B; Aman, A; Moran, MF; Prakesch, M; Poda, G; Marcellus, R; Uehling, D; Samarzija, M; Jakopovic, M; Tsao, MS; Shepherd, FA; Sacher, A; Leighl, N; Akhmanova, A; Al-awar, R; Zerial, M; Stagljar, I or concate me.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles