Zhang, ZP; Yin, ZF; Li, JY; Wang, ZP; Wu, QJ; Wang, J; Liu, Y; Cheng, MS in [Zhang, Zuo-Peng; Yin, Ze-Fa; Li, Jia-Yue; Wang, Zhi-Peng; Wu, Qian-Jie; Wang, Jian; Liu, Yang; Cheng, Mao-Sheng] Shenyang Pharmaceut Univ, Minist Educ, Sch Pharmaceut Engn, Key Lab Struct Based Drug Design & Discovery, Shenyang 110016, Liaoning, Peoples R China published Synthesis, Molecular Docking Analysis, and Carbonic Anhydrase Inhibitory Evaluations of Benzenesulfonamide Derivatives Containing Thiazolidinone in 2019.0, Cited 35.0. Name: 3-Hydroxybenzaldehyde. The Name is 3-Hydroxybenzaldehyde. Through research, I have a further understanding and discovery of 100-83-4.
To find novel human carbonic anhydrase (hCA) inhibitors, we synthesized thirteen compounds by combining thiazolidinone with benzenesulfonamide. The result of the X-ray single-crystal diffraction experiment confirmed the configuration of this class of compounds. The enzyme inhibition assays against hCA II and IX showed desirable potency profiles, as effective as the positive controls. The docking studies revealed that compounds (2) and (7) efficiently bound in the active site cavity of hCA IX by forming sufficient interactions with active site residues. The fragment of thiazolidinone played an important role in the binding of the molecules to the active site.
About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Zhang, ZP; Yin, ZF; Li, JY; Wang, ZP; Wu, QJ; Wang, J; Liu, Y; Cheng, MS or concate me.. Name: 3-Hydroxybenzaldehyde
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,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles