Authors Ezzat, HG; Bayoumi, AH; Sherbiny, FF; El-Morsy, AM; Ghiaty, A; Alswah, M; Abulkhair, HS in SPRINGER published article about ADENOSINE RECEPTORS; A(2B); ANTITUMOR; SENSITIVITY in [Ezzat, Hany G.; Bayoumi, Ashraf H.; Sherbiny, Farag F.; El-Morsy, Ahmed M.; Ghiaty, Adel; Alswah, Mohamed; Abulkhair, Hamada S.] Al Azhar Univ, Fac Pharm, Pharmaceut Organ Chem Dept, Cairo 11884, Egypt; [Sherbiny, Farag F.] Misr Univ Sci & Technol MUST, Coll Pharm, Pharmaceut Organ Chem Dept, 6th October City, Egypt; [El-Morsy, Ahmed M.] Islamic Univ, Coll Pharm, Pharmaceut Chem Dept, Najaf 54001, Iraq; [Abulkhair, Hamada S.] Horus Univ Egypt, Fac Pharm, Pharmaceut Chem Dept, Int Costal Rd, New Damietta, Egypt in 2021, Cited 28. Safety of 4-Methoxybenzaldehyde. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5
Many shreds of evidence have recently correlated A2B receptor antagonism with anticancer activity. Hence, the search for an efficient A2B antagonist may help in the development of a new chemotherapeutic agent. In this article, 23 new derivatives of [1,2,4]triazolo[4,3-a]quinoxaline were designed and synthesized and its structures were confirmed by different spectral data and elemental analyses. The results of cytotoxic evaluation of these compounds showed six promising active derivatives with IC(50)values ranging from 1.9 to 6.4 mu M on MDA-MB 231 cell line. Additionally, molecular docking for all synthesized compounds was performed to predict their binding affinity toward the homology model of A2B receptor as a proposed mode of their cytotoxic activity. Results of molecular docking were strongly correlated with those of the cytotoxic study. Finally, structure activity relationship analyses of the new compounds were explored. [GRAPHICS] .
Welcome to talk about 123-11-5, If you have any questions, you can contact Ezzat, HG; Bayoumi, AH; Sherbiny, FF; El-Morsy, AM; Ghiaty, A; Alswah, M; Abulkhair, HS or send Email.. Safety of 4-Methoxybenzaldehyde
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles