I found the field of Pharmacology & Pharmacy very interesting. Saw the article Discovery and Biological Evaluation of N-Methyl-pyrrolo[2,3-b]pyridine-5-carboxamide Derivatives as JAK1-Selective Inhibitors published in 2021. Application In Synthesis of 4-Methoxybenzaldehyde, Reprint Addresses Kang, S (corresponding author), Ewha Womans Univ, Coll Pharm, Seoul 03760, South Korea.; Kang, S (corresponding author), Ewha Womans Univ, Grad Sch Pharmaceut Sci, Seoul 03760, South Korea.. The CAS is 123-11-5. Through research, I have a further understanding and discovery of 4-Methoxybenzaldehyde
Janus kinase 1 (JAK1) plays a key role in most cytokine-mediated inflammatory and autoimmune responses through JAK/STAT signaling; thus, JAK1 inhibition is a promising therapeutic strategy for several diseases. Analysis of the binding modes of current JAK inhibitors to JAK isoforms allowed the design of N-alkyl-substituted 1-H-pyrrolo[2,3-b] pyridine carboxamide as a JAK1-selective scaffold, and the synthesis of various methyl amide derivatives provided 4- ((cis-1- (4-chlorobenzyl)-2-methylpiperidin-4-yl) amino-N-methyl-1H-pyrrolo[2,3-b]pyridine-5-carboxamide (31g) as a potent JAK1-selective inhibitor. In particular, the (S,S)-enantiomer of 31g (38a) exhibited excellent potency for JAK1 and selectivity over JAK2, JAK3, and TYK2. On investigating the effect of 31g on hepatic fibrosis, it was found that it reduces the proliferation and fibrogenic gene expression of TGF-beta-induced hepatic stellate cells (HSCs). Specifically, 31g significantly inhibited TGF-beta-induced migration of HSCs at 0.25 mu M in wound-healing assays.
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Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles