I found the field of Chemistry; Crystallography very interesting. Saw the article Synthesis, characterization, and anti-cancer activity of chalcone derivatives as-potent anaplastic lymphoma kinase inhibitors published in 2021.0. COA of Formula: C8H8O2, Reprint Addresses Lakshmanan, S (corresponding author), Presidency Coll, Dept Chem, Chennai 600005, Tamil Nadu, India.; Lakshmanan, S (corresponding author), Bharath Univ, BIHER, Dept Chem, Chennai 600073, Tamil Nadu, India.. The CAS is 123-11-5. Through research, I have a further understanding and discovery of 4-Methoxybenzaldehyde
Chalcone derivatives (7a-k) have been synthesized and characterized by H-1-NMR, C-13-NMR, mass, and elemental analysis. The synthesized compounds 7a, 7d, and 7g have been examined and it is confirmed that the most promising cytotoxicity and also cell morphology analysis exhibited good apoptotic activity against lung cancer A549 cell. The free energy binding of compound 7d exhibits – 8.96 kcal/mol with five hydrogen bonding Asn1254, Arg1253, Asp1249, and Gly1123 amino acids of ALK receptors. The LUMO of the electron density present in alpha, beta-double bond and influence the anticancer activity. The Mulliken atomic charges and MEPs are scrutinizing the ligand interaction with the amino acid binding of ALK receptors. UV-visible and photoluminescence spectra showed that the properties of chalcone derivatives have a significant effect on the visible absorption and emission maxima (531-535 nm) red shift in the emission spectra which also systematically investigated electrochemical in various solvents with increasing solvent polarity.
COA of Formula: C8H8O2. Welcome to talk about 123-11-5, If you have any questions, you can contact Lakshmanan, S; Govindaraj, D; Mahalakshmi, K; Thirumurugan, K; Ramalakshmi, N; Antony, SA or send Email.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles