Recently I am researching about UNSATURATED CARBOXYLIC-ACIDS; ASYMMETRIC HYDROGENATION; ENANTIOSELECTIVE HYDROGENATION; SELECTIVE REDUCTION; HYDROBORATION; COMPLEXES; ESTERS; BOND, Saw an article supported by the . Formula: C5H8O2. Published in WILEY-V C H VERLAG GMBH in WEINHEIM ,Authors: Reed, JH; Cramer, N. The CAS is 80-59-1. Through research, I have a further understanding and discovery of (E)-2-Methylbut-2-enoic acid
The potent nucleophilicity and remarkably low basicity of 1,3,2-diazaphospholenes (DAPs) is exploited in a catalytic, metal-free 1,4-reduction of free alpha,beta-unsaturated carboxylic acids. Notably, the reduction occurs without a prior deprotonation of the carboxylic acid moiety and hence does not consume an additional hydride equivalent. This highlights the excellent nucleophilic character and low basicity of DAP-hydrides. Functional groups such as Cbz group or alkyl halides which can be problematic with classical transition-metal catalysts are well tolerated in the DAP-catalyzed process. Moreover, the transformation is characterized by a low catalyst loading, mild reaction conditions at ambient temperature as well as fast reaction times and high yields. The proof-of-principle for a catalytic enantioselective version is described.
Formula: C5H8O2. Welcome to talk about 80-59-1, If you have any questions, you can contact Reed, JH; Cramer, N or send Email.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles