An article Use of a scaffold peptide in the biosynthesis of amino acid-derived natural products WOS:000476479200053 published article about CARRIER-PROTEIN; INSIGHTS; INTERMEDIATE; COMPLEX; TOOL in [Ting, Chi P.; van der Donk, Wilfred A.] Univ Illinois, Carl R Woese Inst Genom Biol, Urbana, IL 61801 USA; [Funk, Michael A.; Zhang, Zhengan; van der Donk, Wilfred A.] Univ Illinois, Dept Chem, Urbana, IL 61801 USA; [Halaby, Steve L.; Gonen, Tamir] Univ Calif Los Angeles, Howard Hughes Med Inst, Los Angeles, CA 90095 USA; [Halaby, Steve L.; Gonen, Tamir] Univ Calif Los Angeles, David Geffen Sch Med, Dept Biol Chem, Los Angeles, CA 90095 USA; [Halaby, Steve L.; Gonen, Tamir] Univ Calif Los Angeles, David Geffen Sch Med, Dept Physiol, Los Angeles, CA 90095 USA; [van der Donk, Wilfred A.] Univ Illinois, Howard Hughes Med Inst, Urbana, IL 61801 USA; [Funk, Michael A.] Amer Assoc Advancement Sci, Washington, DC 20005 USA in 2019.0, Cited 49.0. The Name is Benzyl Alcohol. Through research, I have a further understanding and discovery of 100-51-6. Computed Properties of C7H8O
Genome sequencing of environmental bacteria allows identification of biosynthetic gene clusters encoding unusual combinations of enzymes that produce unknown natural products. We identified a pathway in which a ribosomally synthesized small peptide serves as a scaffold for nonribosomal peptide extension and chemical modification. Amino acids are transferred to the carboxyl terminus of the peptide through adenosine triphosphate and amino acyl-tRNA-dependent chemistry that is independent of the ribosome. Oxidative rearrangement, carboxymethylation. and proteolysis of a terminal cysteine yields an amino acid-derived small molecule. Microcrystal electron diffraction demonstrates that the resulting product is isosteric to glutamate. We show that a similar peptide extension is used during the biosynthesis of the ammosamides, which are cytotoxic pyrroloquinoline alkaloids. These results suggest an alternative paradigm for biosynthesis of amino acid-derived natural products.
Computed Properties of C7H8O. Welcome to talk about 100-51-6, If you have any questions, you can contact Ting, CP; Funk, MA; Halaby, SL; Zhang, ZG; Gonen, T; van der Donk, WA or send Email.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles