Recently I am researching about (+)-USNIC ACID, Saw an article supported by the Science and Technology Incubator Youth Program [3/2018/H-D-KHCN-VU]. Published in TAYLOR & FRANCIS LTD in ABINGDON ,Authors: Nguyen, VK; Sichaem, J; Nguyen, HH; Nguyen, XH; Huynh, TTL; Nguyen, TP; Niamnont, N; Mac, DH; Pham, DD; Chavasiri, W; Nguyen, KPP; Duong, TH. The CAS is 123-11-5. Through research, I have a further understanding and discovery of 4-Methoxybenzaldehyde. Computed Properties of C8H8O2
A series of usnic acid benzylidene derivatives (groups I-V) were designed, synthesized and evaluated for their anticancer activity in the search for potentially new anticancer agents. Compounds 1a, 5b, 2b, 2e and 2f exhibited the most potent cytotoxcity against K562 cell line with IC50 values of 10.0 +/- 3.6, 5.6 +/- 0.4, 8.8 +/- 1.0, 4.5 +/- 0.1 and 8.4 +/- 0.4 mu M, respectively. It is noteworthy that compound 2e displayed potent cytotoxicity against K562 cells without any cytotoxic effect on HEK293 normal cell line.
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Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles