SDS of cas: 123-11-5. Authors Lara, LS; Lechuga, GC; Moreira, CD; Santos, TB; Ferreira, VF; da Rocha, DR; Pereira, MCS in MDPI published article about in [Lara, Leonardo S.; Lechuga, Guilherme C.; Pereira, Mirian C. S.] Fiocruz MS, Inst Oswaldo Cruz, Lab Ultraestrutura Celular, Av Brasil 4365 Manguinhos, BR-21040900 Rio De Janeiro, RJ, Brazil; [Moreira, Caroline dos S.; Santos, Thais B.; Ferreira, Vitor F.; da Rocha, David R.] Univ Fed Fluminense, Inst Quim, Dept Quim Organ, Rua Outeiro Sao Joao Batista, BR-24020141 Niteroi, RJ, Brazil in 2021, Cited 45. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5
Chagas disease (CD) still represents a serious public health problem in Latin America, even after more than 100 years of its discovery. Clinical treatments (nifurtimox and benznidazole) are considered inadequate, especially because of undesirable side effects and low efficacy in the chronic stages of the disease, highlighting the urgency for discovering new effective and safe drugs. A small library of compounds (1a-i and 2a-j) was designed based on the structural optimization of a Hit compound derived from 1,4-naphthoquinones (C2) previously identified. The biological activity, structure-activity relationship (SAR), and the in silico physicochemical profiles of the naphthoquinone derivatives were analyzed. Most modifications resulted in increased trypanocidal activity but some substitutions also increased toxicity. The data reinforce the importance of the chlorine atom in the thiophenol benzene ring for trypanocidal activity, highlighting 1g, which exhibit a drug-likeness profile, as a promising compound against Trypanosoma cruzi. SAR analysis also revealed 1g as cliff generator in the structure-activity similarity map (SAS maps). However, compounds C2 and 1g were unable to reduce parasite load, and did not prevent mouse mortality in T. cruzi acute infection. Phenotypic screening and computational analysis have provided relevant information to advance the optimization and design of new 1,4-naphthoquinone derivatives with a better pharmacological profile.
SDS of cas: 123-11-5. Bye, fridends, I hope you can learn more about C8H8O2, If you have any questions, you can browse other blog as well. See you lster.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles