Computed Properties of C5H8O2. I found the field of Chemistry very interesting. Saw the article Ring Expansion Leads to a More Potent Analogue of Ipomoeassin F published in 2020, Reprint Addresses Shi, WQ (corresponding author), Ball State Univ, Dept Chem, Muncie, IN 47306 USA.. The CAS is 80-59-1. Through research, I have a further understanding and discovery of (E)-2-Methylbut-2-enoic acid.
Two new ring-size-varying analogues (2 and 3) of ipomoeassin F were synthesized and evaluated. Improved cytotoxicity (IC50: from 1.8 nM) and in vitro protein translocation inhibition (IC50: 35 nM) derived from ring expansion imply that the binding pocket of Sec61 alpha (isoform 1) can accommodate further structural modifications, likely in the fatty acid portion. Streamlined preparation of the key diol intermediate 5 enabled gram-scale production, allowing us to establish that ipomoeassin F is biologically active in vivo (MTD: similar to 3 mg/kg).
Bye, fridends, I hope you can learn more about C5H8O2, If you have any questions, you can browse other blog as well. See you lster.. Computed Properties of C5H8O2
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles