An article Bisphenol A degradation pathway and associated metabolic networks in Escherichia coli harboring the gene encoding CYP450 WOS:000524462500016 published article about CYTOCHROME-P450; BIODEGRADATION; CELLS; AMPG in [Wang, Wenxin; Qin, Huaming; Long, Yan; Ye, Jinshao] Jinan Univ, Sch Environm, Guangdong Key Lab Environm Pollut & Hlth, Guangzhou 510632, Peoples R China; [Yu, Henan] Guangdong Ocean Engn Technol Sch, Guangzhou 510320, Peoples R China; [Qu, Yanfen] Zhongji Ecol Sci & Technol Co Ltd, Guangzhou 511443, Peoples R China in 2020.0, Cited 40.0. Recommanded Product: 99-93-4. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4
Although bisphenol A (BPA) can be transformed by CYP450, the metabolic networks involved in regulating the transformation processes are not clear. In this study, Escherichia coli. harboring the gene encoding CYP450 was used as a model to elucidate the BPA degradation pathway and the associated metabolic network using a proteomic approach. The results showed that CYP450 promotes the transformation of BPA, generating 1,2-bis(4-hydroxyphenyl)-2-propanol and 2,2-bis(4-hydroxyphenyl)-1-propanol, with hydroquinone and 4-(2-hydroxypropan-2-yl)phenol formed in another pathway. The DNA adducts formed by 1,4-benzoquinone were reduced, and CYP450 played a positive role in cellular homeostasis by promoting the transformation of BPA and mismatch repair. An increase in the synthesis of cell membrane lipids was observed after dislodging BPA. BPA disturbed folate metabolism by decreasing the abundance of dihydrofolate reductase, which inhibited microbial metabolism in the absence of CYP450. The findings of this study revealed the molecular mechanism associated with the metabolic network responsible for pollutant tolerance and degradation.
Recommanded Product: 99-93-4. Welcome to talk about 99-93-4, If you have any questions, you can contact Wang, WX; Yu, HN; Qin, HM; Long, Y; Ye, JS; Qu, YF or send Email.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles