COA of Formula: C7H8O. Recently I am researching about ENANTIOSELECTIVE TOTAL-SYNTHESIS; AMPHIBIAN SKIN; POISON FROGS; ANTIMICROBIAL PEPTIDES; ARTHROPOD ALKALOIDS; PUMILIOTOXIN 251D; A ALKALOIDS; IMINIUM ION; PRECURSORS, Saw an article supported by the European Regional Development Fund (ERDF)European Commission [1.1.1.2/VIAA/1/16/243]. Published in TAYLOR & FRANCIS LTD in ABINGDON ,Authors: Zvejniece, L; Dambrova, M; Smits, G. The CAS is 100-51-6. Through research, I have a further understanding and discovery of Benzyl Alcohol
The total synthesis of both the double bond isomers of indolizine alkaloid 8-deoxypumiliotoxin 193H has been accomplished. Both the double bond isomers Z-4 and E-4 induced convulsions and inhibited neuro-muscular activity at a dose of 25 mg/kg after intraperitoneal injection in mice. The lethal dose of Z-4 and E-4 was 100 mg/kg, indicating that 8-deoxypumiliotoxin 193H is 10-times less toxic than the known pumiliotoxin (+)-251 D.
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Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles