An article Palladium-catalyzed Tsuji-Trost-type reaction of benzofuran-2-ylmethyl acetates with nucleophiles WOS:000607364700033 published article about CROSS-COUPLING REACTIONS; UNSYMMETRICAL DIARYL SULFONES; C BOND FORMATION; BETA-AMYLOID AGGREGATION; PROPARGYLIC CARBONATES; DIRECT ARYLATION; ANGIOTENSIN-II; SUBSTITUTED 2,3-DIHYDROFURANS; BENZYLIC SUBSTITUTION; RECEPTOR ANTAGONISTS in [Arcadi, Antonio] Univ LAquila, Dipartimento Sci Fis & Chim, Via Vetoio, I-67100 Coppito, AQ, Italy; [Fabrizi, Giancarlo; Fochetti, Andrea; Goggiamani, Antonella; Iazzetti, Antonia; Marrone, Federico; Mazzoccanti, Giulia; Serraiocco, Andrea] Sapienza Univ Roma, Dipartimento Chim & Tecnol Farmaco, Ple A Moro 5, I-00185 Rome, Italy; [Ghirga, Francesca] Ist Italian Tecnol, Ctr Life Nano Sci Sapienza, Viale Regina Elena 291, I-00161 Rome, Italy in 2021.0, Cited 122.0. Safety of Mequinol. The Name is Mequinol. Through research, I have a further understanding and discovery of 150-76-5
The palladium-catalyzed benzylic-like nucleophilic substitution of benzofuran-2-ylmethyl acetate with N, S, O and C soft nucleophiles has been investigated. The success of the reaction is dramatically influenced by the choice of catalytic system: with nitrogen based nucleophiles the reaction works well with Pd-2(dba)(3)/dppf, while with sulfur, oxygen and carbo-nucleophiles [Pd(eta(3)-C3H5)Cl](2)/XPhos is more efficient. The regiochemical outcome shows that the nucleophilic substitution occurs only on the benzylic position of the eta(3)-(benzofuryl)methyl complex. The high to excellent yields and the simplicity of the experimental procedure make this protocol a versatile synthetic tool for the preparation of 2-substituted benzo[b]furans.
About Mequinol, If you have any questions, you can contact Arcadi, A; Fabrizi, G; Fochetti, A; Ghirga, F; Goggiamani, A; Iazzetti, A; Marrone, F; Mazzoccanti, G; Serraiocco, A or concate me.. Safety of Mequinol
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Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles