An article A Novel Class of N-Sulfonyl and N-Sulfamoyl Noscapine Derivatives that Promote Mitotic Arrest in Cancer Cells WOS:000495751900001 published article about BIOLOGICAL EVALUATION; MULTIDRUG-RESISTANCE; MOLECULAR-MECHANISMS; NATURAL-PRODUCTS; TUBULIN-BINDING; OVEREXPRESSION; PHARMACOKINETICS; MICROTUBULES; NARCOTINE; ANALOGS in [Yong, Cassandra; Devine, Shane M.; Capuano, Ben; Scammells, Peter J.] Monash Univ, Med Chem, Monash Inst Pharmaceut Sci, 381 Royal Parade, Parkville, Vic 3052, Australia; [Gao, Xuexin; Yan, Angelina; Callaghan, Richard] Australian Natl Univ, Res Sch Biol, Canberra, ACT 0200, Australia; [Gao, Xuexin; Yan, Angelina; Callaghan, Richard] Australian Natl Univ, Sch Med, Canberra, ACT 0200, Australia in 2019.0, Cited 40.0. COA of Formula: C7H8O. The Name is Benzyl Alcohol. Through research, I have a further understanding and discovery of 100-51-6
Noscapine displays weak anticancer efficacy and numerous research efforts have attempted to generate more potent noscapine analogues. These modifications included the replacement of the N-methyl group in the 6 ‘-position with a range of substituents, where N-ethylcarbamoyl substitution was observed to possess enhanced anticancer activity. Herein, we describe advances in this area, namely the synthesis and pharmacological evaluation of a series of N-sulfonyl and N-sulfamoyl noscapine derivatives. A number of these sulfonyl-containing noscapinoids demonstrated improved activities compared to noscapine. ((R)-5-((S)-4,5-Dimethoxy-1,3-dihydroisobenzofuran-1-yl)-4-methoxy-6-((1-methyl-1H-imidazol-4-yl)sulfonyl)-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinoline) (14 q) displayed sub-micromolar activities of 560, 980, 271 and 443 nM against MCF-7, PANC-1, MDA-MB-435 and SK-MEL-5 cells, respectively. This antiproliferative effect was also maintained against drug-resistant NCI/Adr(RES) cells despite high expression of the multidrug efflux pump, P-glycoprotein.
COA of Formula: C7H8O. About Benzyl Alcohol, If you have any questions, you can contact Yong, C; Devine, SM; Gao, XX; Yan, A; Callaghan, R; Capuano, B; Scammells, PJ or concate me.
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Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles