Formula: C8H8O2. Authors Schaller, E; Ma, A; Gosch, LC; Klefenz, A; Schaller, D; Goehringer, N; Kaps, L; Schuppan, D; Volkamer, A; Schobert, R; Biersack, B; Nitzsche, B; Hopfner, M in MDPI published article about in [Schaller, Eva; Schobert, Rainer; Biersack, Bernhard] Univ Bayreuth, Organ Chem Lab, Univ Str 30, D-95440 Bayreuth, Germany; [Ma, Andi; Gosch, Lisa Chiara; Goehringer, Nils; Nitzsche, Bianca] Charite Univ Med Berlin, Inst Physiol, Charitepl 1, D-10117 Berlin, Germany; [Gosch, Lisa Chiara; Schaller, David; Volkamer, Andrea] Charite Univ Med Berlin, Inst Physiol, Silico Toxicol & Struct Bioinformat, Charitepl 1, D-10117 Berlin, Germany; [Klefenz, Adrian; Kaps, Leonard; Schuppan, Detlef] Johannes Gutenberg Univ Mainz, Univ Med Ctr, Inst Translat Immunol, Langenbeckstr 1, D-55131 Mainz, Germany; [Schuppan, Detlef] Harvard Med Sch, Beth Israel Deaconess Med Ctr, Div Gastroenterol, 330 Brookline Ave, Boston, MA 02215 USA in 2021, Cited 61. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5
New 2-(thien-2-yl)-acrylonitriles with putative kinase inhibitory activity were prepared and tested for their antineoplastic efficacy in hepatoma models. Four out of the 14 derivatives were shown to inhibit hepatoma cell proliferation at (sub-)micromolar concentrations with IC50 values below that of the clinically relevant multikinase inhibitor sorafenib, which served as a reference. Colony formation assays as well as primary in vivo examinations of hepatoma tumors grown on the chorioallantoic membrane of fertilized chicken eggs (CAM assay) confirmed the excellent antineoplastic efficacy of the new derivatives. Their mode of action included an induction of apoptotic capsase-3 activity, while no contribution of unspecific cytotoxic effects was observed in LDH-release measurements. Kinase profiling of cancer relevant protein kinases identified the two 3-aryl-2-(thien-2-yl)acrylonitrile derivatives 1b and 1c as (multi-)kinase inhibitors with a preferential activity against the VEGFR-2 tyrosine kinase. Additional bioinformatic analysis of the VEGFR-2 binding modes by docking and molecular dynamics calculations supported the experimental findings and indicated that the hydroxy group of 1c might be crucial for its distinct inhibitory potency against VEGFR-2. Forthcoming studies will further unveil the underlying mode of action of the promising new derivatives as well as their suitability as an urgently needed novel approach in HCC treatment.
Welcome to talk about 123-11-5, If you have any questions, you can contact Schaller, E; Ma, A; Gosch, LC; Klefenz, A; Schaller, D; Goehringer, N; Kaps, L; Schuppan, D; Volkamer, A; Schobert, R; Biersack, B; Nitzsche, B; Hopfner, M or send Email.. Formula: C8H8O2
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles