An article Aminocyanopyridines as anti-lung cancer agents by inhibiting the STAT3 pathway WOS:000474276900015 published article about FEEDBACK ACTIVATION; DRUG-RESISTANCE; DERIVATIVES; BREAST in [Xu, Lingyuan; Yang, Lehe; Fan, Shiqian; Wang, Liangxing; Huang, Xiaoying] Wenzhou Med Univ, Key Lab Heart & Lung, Affiliated Hosp 1, Div Pulm Med, Wenzhou 325000, Zhejiang, Peoples R China; [Qiu, Sensen; Xu, Haitang; Shen, Liqun] Guangxi Univ Nationalities, Coll Chem & Chem Engn, Nanning 530006, Peoples R China; [Xu, Lingyuan; Yang, Lehe; Cui, Ri; Zhao, Chengguang] Wenzhou Med Univ, Sch Pharmaceut Sci, Chem Biol Res Ctr, Wenzhou, Zhejiang, Peoples R China; [Liu, Xu] Guangxi Univ, Sch Med, Nanning, Guangxi, Peoples R China; [Fu, Weitao] Zhejiang Univ, Coll Pharmaceut Sci, Hangzhou, Zhejiang, Peoples R China in 2019.0, Cited 33.0. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4. COA of Formula: C8H8O2
Lung cancer is a leading cause of cancer-related death worldwide. Cyanopyridines and aminocyanopyridines with carbon-nitrogen bonds have been proved to exert significant anticancer, antibacterial, and anti-inflammatory effects. In this study, we showed that aminocyanopyridine 3o and 3k displaying potent antitumor activity via inhibiting the signal transducer and activator of transcription 3 (STAT3) pathway. They blocked the constitutive STAT3 phosphorylation in a dose- and time-dependent manner and regulated the transcription of STAT3 target genes encoding apoptosis factors. Most importantly, 3o also inhibited interleukin-6-induced STAT3 activation and nuclear localization. Furthermore, 3o significantly inhibited the tumor growth of H460-derived xenografts. Taken together, these findings suggest that 3o and 3k are promising therapeutic drug candidates for lung cancer by inhibiting persistent STAT3 signaling.
COA of Formula: C8H8O2. Welcome to talk about 99-93-4, If you have any questions, you can contact Xu, LY; Qiu, SS; Yang, LH; Xu, HT; Liu, X; Fan, SQ; Cui, R; Fu, WT; Zhao, CG; Shen, LQ; Wang, LX; Huang, XY or send Email.
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Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles