In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 1011-65-0, name is Methyl 1H-indole-5-carboxylate, introducing its new discovery. COA of Formula: C10H9NO2
The invention discloses a method for synthesizing 2 – tri-isopropyl propyl silicon-based acetylene of indole compounds method, first of all in order to indole compound as a raw material, in the sodium hydride under alkaline conditions, through the indole or substituted indole with 2 – chloro pyrimidine reaction to produce 1 – (pyrimidin – 2 – yl) – 1H – indole compound, to the indole compound is introduced in the pyrimidine guide group, after 1 – (pyrimidin – 2 – yl) – 1H – indole compounds in double-b nitrile palladium chloride, cesium carbonate, six fluorine stibium acid silver, aluminum oxide, silicon-based acetylene bromine and three of di-isopropyl 1, 4 – dioxo has ring solvent the participation of the alkynylated reaction, the final resultant 2 – tri-isopropyl propyl silicon-based acetylene indole compounds. The method of the invention using a low palladium catalyst under milder conditions effective synthesis of the target product 2 – tri-isopropyl propyl silicon-based acetylene indole compounds. This invention uses direct hydrocarbon activation reaction method, can be dispensed with-session agglomerating process, thereby reducing the reaction steps, improves the reaction economical efficiency. (by machine translation)
The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 1011-65-0 is helpful to your research. COA of Formula: C10H9NO2
Reference：
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles