An article Bioinspired Oxidative Cyclization of the Geissoschizine Skeleton for Enantioselective Total Synthesis of Mavacuran Alkaloids WOS:000476615900026 published article about NUCLEAR-MAGNETIC-RESONANCE; DEPLANCHEI VAN HEURCK; 2 INDOLE MOIETIES; STRICTAMINE; STRYCHNOS; (+/-)-AKUAMMICINE; BIPLEIOPHYLLINE; SPECTROSCOPY; STRATEGY; PYRONE in [Jarret, Maxime; Tap, Aurelien; Kouklovsky, Cyrille; Vincent, Guillaume] Univ Paris Saclay, Univ Paris Sud, CNRS, ICMMO,Equipe MSMT, 15 Rue Georges Clemenceau, F-91405 Orsay, France; [Turpin, Victor; Poupon, Erwan; Evanno, Laurent] Univ Paris Saclay, Univ Paris Sud, BioCIS, Pharmacognosie & Chim Subst Nat, F-92290 Chatenay Malabry, France; [Gallard, Jean-Francois] Univ Paris Saclay, CNRS UPR 2301, ICSN, F-91198 Gif Sur Yvette, France in 2019.0, Cited 61.0. Product Details of 100-51-6. The Name is Benzyl Alcohol. Through research, I have a further understanding and discovery of 100-51-6
Reported is the enantioselective total syntheses of mavacuran alkaloids, (+)- taberdivarine H, (+)- 16- hydroxymethyl- pleiocarpamine, and (+)- 16- epi- pleiocarpamine, and their postulated biosynthetic precursor 16- formyl- pleiocarpamine. This family of monoterpene indole alkaloids is a target of choice since some of its members are subunits of intricate bisindole alkaloids such as bipleiophylline. Inspired by the biosynthetic hypothesis, an oxidative coupling approach from the geissoschizine framework to form the N1 @ C16 bond was explored. Quaternization of the aliphatic nitrogen center was key to achieving the oxidative coupling induced by KHMDS/ I2 as it masks the nucleophilicity of the aliphatic nitrogen center and locks in the required cis conformation.
Product Details of 100-51-6. Welcome to talk about 100-51-6, If you have any questions, you can contact Jarret, M; Turpin, V; Tap, A; Gallard, JF; Kouklovsky, C; Poupon, E; Vincent, G; Evanno, L or send Email.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles