Formula: C8H8O2. Authors Zhu, HJ; Li, WL; Shuai, W; Liu, Y; Yang, LM; Tan, YC; Zheng, TD; Yao, H; Xu, JY; Zhu, ZY; Yang, DH; Chen, ZS; Xu, ST in ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER published article about in [Zhu, Huajian; Li, Wenlong; Shuai, Wen; Liu, Yang; Yang, Limei; Tan, Yuchen; Zheng, Tiandong; Yao, Hong; Xu, Jinyi; Xu, Shengtao] China Pharmaceut Univ, State Key Lab Nat Med, 24 Tong Jia Xiang, Nanjing 210009, Peoples R China; [Zhu, Huajian; Li, Wenlong; Shuai, Wen; Liu, Yang; Yang, Limei; Tan, Yuchen; Zheng, Tiandong; Yao, Hong; Xu, Jinyi; Xu, Shengtao] China Pharmaceut Univ, Dept Med Chem, 24 Tong Jia Xiang, Nanjing 210009, Peoples R China; [Zhu, Zheying] Univ Nottingham, Sch Pharm, Div Mol Therapeut & Formulat, Univ Pk Campus, Nottingham NG7 2RD, England; [Yang, Dong-Hua; Chen, Zhe-Sheng] St Johns Univ, Coll Pharm & Hlth Sci, 8000 Utopia Pkwy, Queens, NY 11439 USA in 2021, Cited 64. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5
A series of novel N-benzylbenzamide derivatives were designed and synthesized as tubulin polymerization inhibitors. Among fifty-one target compounds, compound 20b exhibited significant anti-proliferative activities with IC50 values ranging from 12 to 27 nM against several cancer cell lines, and possessed good plasma stability and satisfactory physicochemical properties. Mechanism studies demonstrated that 20b bound to the colchicine binding site and displayed potent anti-vascular activity. Notably, the corresponding disodium phosphate 20b-P exhibited an excellent safety profile with the LD50 value of 599.7 mg/kg (i.v. injection), meanwhile, it significantly inhibited tumor growth and decreased microvessel density in liver cancer cell H22 allograft mouse model without obvious toxicity. Collectively, 20b and 20b-P are novel promising anti-tubulin agents with more druggable properties and deserve to be further investigated for cancer therapy. (C) 2021 Elsevier Masson SAS. All rights reserved.
About 4-Methoxybenzaldehyde, If you have any questions, you can contact Zhu, HJ; Li, WL; Shuai, W; Liu, Y; Yang, LM; Tan, YC; Zheng, TD; Yao, H; Xu, JY; Zhu, ZY; Yang, DH; Chen, ZS; Xu, ST or concate me.. Formula: C8H8O2
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles