Esters, Including Triglycerides, and Hydrogen as Feedstocks for the Ruthenium-Catalyzed Direct N-Alkylation of Amines was written by Adam, Rosa;Cabrero-Antonino, Jose R.;Junge, Kathrin;Jackstell, Ralf;Beller, Matthias. And the article was included in Angewandte Chemie, International Edition in 2016.Application of 5388-42-1 This article mentions the following:
Triglycerides are used for the direct N-alkylation of amines with mol. hydrogen for the first time. A broad range of interesting and industrially relevant secondary and tertiary amines are obtained in the presence of an in situ formed Ru/Triphos complex. Notably, plant oil can be efficiently applied in this single-step process. Moreover, a variety of other Me esters can be used as N-alkylation agents in the presence of hydrogen for the synthesis of more advanced building blocks. In the experiment, the researchers used many compounds, for example, 2-Phenylisoindolin-1-one (cas: 5388-42-1Application of 5388-42-1).
2-Phenylisoindolin-1-one (cas: 5388-42-1) belongs to indole derivatives. Indole is an important structural motif of various drugs, therapeutic leads besides its prevalence in numerous natural products, agrochemicals, perfumery, and dyes. More than 200 indole derivatives have already been marketed as drugs or are under advanced stages of clinical trials.Application of 5388-42-1
Referemce:
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Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles