Application In Synthesis of Mequinol. Authors Brotherton, EE; Jesson, CP; Warren, NJ; Smallridge, MJ; Armes, SP in WILEY-V C H VERLAG GMBH published article about in [Brotherton, Emma E.; Jesson, Craig P.; Warren, Nicholas J.; Armes, Steven P.] Univ Sheffield, Chem, Dainton Bldg,Brook Hill, Sheffield S3 7HF, S Yorkshire, England; [Smallridge, Mark J.] GEO Specialty Chem, Charleston Rd, Southampton SO45 3ZG, Hants, England in 2021.0, Cited 50.0. The Name is Mequinol. Through research, I have a further understanding and discovery of 150-76-5
Aldehyde groups enable facile conjugation to proteins, enzymes, oligonucleotides or fluorescent dyes, yet there are no literature examples of water-soluble aldehyde-functional vinyl monomers. We report the synthesis of a new hydrophilic cis-diol-based methacrylic monomer (GEO5MA) by transesterification of isopropylideneglycerol penta(ethylene glycol) using methyl methacrylate followed by acetone deprotection via acid hydrolysis. The corresponding water-soluble aldehyde monomer, AGEO5MA, is prepared by aqueous periodate oxidation of GEO5MA at 22 degrees C. RAFT polymerization of GEO5MA yields the water-soluble homopolymer, PGEO5MA. Aqueous periodate oxidation of the terminal cis-diol units on PGEO5MA at 22 degrees C affords a water-soluble aldehyde-functional homopolymer (PAGEO5MA). Moreover, a library of hydrophilic statistical copolymers bearing cis-diol and aldehyde groups was prepared using sub-stoichiometric periodate/cis-diol molar ratios. The aldehyde groups on PAGEO5MA homopolymer were reacted in turn with three amino acids to demonstrate synthetic utility.
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Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles