Application In Synthesis of Benzyl Alcohol. In 2019.0 ACTA CHIM SINICA published article about LEWIS PAIR CHEMISTRY; H BOND ACTIVATION; OXYGEN REDUCTION; AROMATIC KETONES; CHLORIDE SYSTEMS; FACILE PROTOCOL; SI-H; HYDROGENATION; ALDEHYDES; DEOXYGENATION in [Sun Guofeng; He Yunqing; Tian Chong; Borzov, Maxim; Nie Wanli] Leshan Normal Univ, Sichuan Prov Key Lab Nat Prod & Small Mol Synth, Leshan 614000, Peoples R China; [Hu Qishan] Sichuan Univ Arts & Sci, Coll Chem & Chem Engn, Dazhou 635000, Peoples R China in 2019.0, Cited 50.0. The Name is Benzyl Alcohol. Through research, I have a further understanding and discovery of 100-51-6.
Recently, the research work concerning B(C6F5)(3) catalyzed reduction of carbonyl compounds revealed that this Lewis acid B(C6F5)(3) presents, actually, a rather water-tolerant system. This fact considerably broadens the scope of the water/base tolerant frustrated Lewis pairs (FLP) chemistry. In this research, an efficient chemoselective reduction of aldehydes and ketones to alcohols catalyzed by the Lewis acid B(C6F5)(3) has been developed. It is the first report about the chemoselective reduction of carbonyl compounds under aqueous conditions catalyzed by FLPs with hydridosilanes as reducing agents. The selectivity and activity of different hydridosilanes and the influence of substituents in carbonyl compounds have been studied. The effect of water concentration on the chemoselectivity of the reaction has also been investigated. It has been found that a 2 similar to 3 fold excess of water relatively to hydridosilanes usually exhibits better selectivity and overall yields than in the equimolar case. The reduction reaction can even be successfully performed with pure water as a solvent without any loss of the reactivity. Such a procedure has been successfully applied to reduce 14 differently substituted aldehydes and ketones into alcohols with up to 100% yields under mild conditions, but failed in case of the diaryl substituted ketones. Both experimental and computational methods have been performed to confirm the possibility of the water mediated mechanism and the effects of different Lewis bases on the LB-H-OH-LA three-component aggregates. These mechanistic studies have revealed that such water mediation between a carbonyl compound and a catalyst advantageously (i) activates the C=O group by protonation and (ii) fixes the catalytic borane moiety by formation of a B-O bond, which to some extent prevents the direct hydrolysis of hydridosilane and makes the reaction possible under moist conditions. Detailed clarification of the actual role of water in the reduction reaction of question will promote the further development of FLP-catalyzed and related reactions in the green chemistry field.
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Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles