10075-48-6, 5-Bromo-3-methyl-1H-indole is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
10075-48-6, Product is prepared according to procedure described in literature (Fraile, J. M.; Le Jeune, K.; Mayoral, J. A.; Ravasio, N.; Zaccheria, F.; Org. Biomol. Chem. 2013, v:11 , pp: 4327-4332). A solution of 5-bromo-3-methyl-1 H-indole (0.30 g; 1.437 mmol; 1.00 eqf.) in dry THF (5.0 ml), is cooled to 0-5C then NaH (60% immersion in mineral oil) (0.14 g; 2.86 mmol; 2.00 eqf.) is added in small portions over 10 min. RM is stirred for 1 h then lodoethane (0.21 ml; 2.86 mmol; 2.0 eqf.) is added dropwise. Reaction mixture is stirred for next 30 min at 0C and 18 h at rt. After mentioned time RM is poured onto ice and extracted with diethyl ether. Organic layers is washed with brine and dried over Na2S04. Solvent is evaporated in vacuo to provide desired product 5- bromo-1 ,3-dimethyl-1 H-indole (0.355 g; 1.33 mmol; yield 93.2%; 84% by UPLC) is obtained as light yellow oil.
As the paragraph descriping shows that 10075-48-6 is playing an increasingly important role.
Reference：
Patent; SELVITA S.A.; FABRITIUS, Charles-Henry Robert Yves; NOWAK, Mateusz Oktawian; WIKLIK, Katarzyna Anna; SABINIARZ, Aleksandra Barbara; BIE?, Marcin Dominik; BUDA, Anna Ma?gorzata; GUZIK, Pawel Szczepan; JAKUBIEC, Krzysztof Roman; MACIUSZEK, Monika; KWIECI?SKA, Katarzyna; TOMCZYK, Mateusz Micha?; GA??ZOWSKI, Micha? Miko?aj; GONDELA, Andrzej; DUDEK, ?ukasz Piotr; (681 pag.)WO2016/180536; (2016); A1;,
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