With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.15903-94-3,6-(Benzyloxy)-1H-indole,as a common compound, the synthetic route is as follows.
To a stirred, cooled [(10OC)] suspension of sodium hydride (80.7 g of a 60% dispersion in mineral oil, 2.02 mol) in anhydrous THF (1.9 L) was added a solution of 6- benzyloxyindole (375 g, 1.68 mol) in anhydrous THF (1.9 L) keeping the temperature below [25OC.] After 2 h at 10C, propylene oxide (140 mL, 2.0 mol) was added dropwise keeping the temperature below [25OC.] After 48 h at 10C, propylene oxide (71 mL, 1.0 mol) was added. After 96 h at 10 oC, saturated aqueous potassium dihydrogenphosphate (3.8 L) and ethyl acetate (3.8 L) were carefully added, the layers were separated and the aqueous solution was extracted with 3.8 L of ethyl acetate. The combined organic extracts were dried over sodium sulfate and concentrated in vacuo to yield a solid (520 g, 110%, contains mineral oil).
15903-94-3, 15903-94-3 6-(Benzyloxy)-1H-indole 260804, aindole-building-block compound, is more and more widely used in various fields.
Reference£º
Patent; ALCON, INC.; WO2003/101379; (2003); A2;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles