With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.20289-27-4,7-(Benzyloxy)-1H-indole,as a common compound, the synthetic route is as follows.
Intermediate 32 Preparation of N-acetyltryotophan acetic anhydride (0.5 ML, 5.2 mmol) was added to a slurry of Intermediate 31 (0.575 g, 2.6 mmol) and DL-serine (0.270 g, 2.6 mmol) in anhydrous acetic acid (5 ML) at room temperature under a nitrogen blanket.The resulting orange solution was heated to reflux and stirred for 24 hours.The cooled mixture then was concentrated under reduced pressure to provide the intermediate N-acetyltryptophan as dark red oil, which was used immediately without purification
20289-27-4, 20289-27-4 7-(Benzyloxy)-1H-indole 260798, aindole-building-block compound, is more and more widely used in various fields.
Reference：
Patent; Orme, Mark W.; Sawyer, Jason Scott; Daugan, Alain Claude-Marie; US2003/225092; (2003); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles