With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.400071-95-6,5-Bromo-1-methyl-1H-indole-3-carboxylic acid,as a common compound, the synthetic route is as follows.
General procedure: To a solution of the amine (1 .0 – 1 .2 eq.) and the carboxyindole (1 .0 eq.) in DCE or EtOAc (0.14 -0.25 M) in a microwave vial, was added DIPEA or TEA (2.2 – 3.0 eq.) followed by T3P (50% in EtOAc) (2.4 – 3.0 eq.). The flask was sealed and heated to 120C-140C for 0.5-1 hr under microwave irradiation. Upon completion the reaction mixture was diluted with EtOAc and washed with NH4CI, Na2CO3 (sat. aq.) and brine. The organic phase was dried over MgSO4 and concentrated in vacuo. The crude product was purified by silica gel column chromatography or pTLC to afford the desired amide.
400071-95-6, As the paragraph descriping shows that 400071-95-6 is playing an increasingly important role.
Reference：
Patent; BIONOMICS LIMITED; HARVEY, Andrew; HUFF, Belinda; SINGH, Rajinder; KUCHEL, Nathan; WO2014/172759; (2014); A1;,
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