With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6960-42-5,7-Nitro-1H-indole,as a common compound, the synthetic route is as follows.,6960-42-5
General procedure: Phthaldialdehyde (1 mmol) was dissolved in glacial acetic acid (15 mL). Then, the corresponding indole (2 mmol) was added to the solution. The mixture was stirred under reflux conditions at 100 C until all of the starting phthaldialdehyde had disappeared, according to TLC-monitoring in CH2Cl2 (100%). The reaction time varied from 2 to 12 h. The reaction mixture was worked up by a dropwise neutralizing of the acid with NaOH (10%) until a pH of 7 was reached, followed extraction with CH2Cl2 (50 mL) for three times. The organic layer was washed with water and brine each for three times.Then it was dried over sodium sulphate, filtered and concentrated in vacuum. The reaction products were given after column chromatography using silica gel and ethyl acetate/cyclohexane mixtures as eluent. The resulting fractions (each 10 mL) were analyzed by TLC to identify the compound containing fractions which were unified and evaporated to dryness to give the target compounds. 11-(1H-Indol-3-yl)-5H-benzo[b]carbazole (3a).
6960-42-5 7-Nitro-1H-indole 23396, aindole-building-block compound, is more and more widely used in various fields.
Reference£º
Article; Ashraf, Kerolos; Yasrebi, Kaveh; Hertlein, Tobias; Ohlsen, Knut; Lalk, Michael; Hilgeroth, Andreas; Molecules; vol. 22; 12; (2017);,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles