SDS of cas: 100-51-6. I found the field of Pharmacology & Pharmacy very interesting. Saw the article Design, Synthesis, and Biological Evaluation of Imidazopyridines as PD-1/PD-L1 Antagonists published in 2021.0, Reprint Addresses Domling, A (corresponding author), Univ Groningen, Dept Drug Design, NL-9713 AV Groningen, Netherlands.. The CAS is 100-51-6. Through research, I have a further understanding and discovery of Benzyl Alcohol.
The PD-1/PD-L1 axis has proven to be a highly efficacious target for cancer immune checkpoint therapy with several approved antibodies. Also, small molecules based on a biphenyl core can antagonize PD-1/PD-L1, leading to the in vitro formation of PD-L1 dimers. However, their development remains challenging, as we do not yet fully understand their mode of action. In this work, we designed a new scaffold based on our previously solved high-resolution structures of low-molecular-weight inhibitors bound to PD-L1. A small compound library was synthesized using the Groebke-Blackburn-Bienayme multicomponent reaction (GBB-3CR), resulting in the structure-activity relationship of imidazo[1,2-a]pyridine-based inhibitors. These inhibitors were tested for their biological activity using various biophysical assays giving potent candidates with low-micromolar PD-L1 affinities. An obtained PD-L1 cocrystal structure reveals the binding to PD-L1. Our results open the door to an interesting bioactive scaffold that could lead to a new class of PD-L1 antagonists.
About Benzyl Alcohol, If you have any questions, you can contact Butera, R; Wazynska, M; Magiera-Mularz, K; Plewka, J; Musielak, B; Surmiak, E; Sala, D; Kitel, R; de Bruyn, M; Nijman, HW; Elsinga, PH; Holak, TA; Domling, A or concate me.. SDS of cas: 100-51-6
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles