Archives for Chemistry Experiments of 4-Methoxy-1H-indole

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A highly regioselective method has been developed for the allylation of indoles with an iridium catalyst. This regioselective procedure uses allylic alcohols directly as allylating agents in the presence of a catalytic amount of sulfuric acid. A wide range of indoles reacted smoothly with asymmetrical allylic alcohols to give the corresponding branched products in branched-to-linear ratios of up to 99:1 and yields as high as 92%. A series of inorganic and organic acids were tested in this approach, and it was shown that acids with pK a values in acetonitrile of less than 15 are required in this iridium-catalyzed system. Georg Thieme Verlag Stuttgart New York.

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Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles