On February 28, 1997, Arnold, Daniel Lee; Moyer, Mikel Paul; Sobolov-Jaynes, Susan Beth published a patent.SDS of cas: 52537-00-5 The title of the patent was Heterocyclic ring-fused pyrimidine derivatives, their intermediates and pharmaceutical compositions containing them. And the patent contained the following:
The invention refers to fused pyrimidines I [Y, together with the attached carbon atoms, form a 5- or 6-membered substituted aromatic ring, optionally containing 1-3 nitrogen atoms, and in addition optionally containing O or S; Z = NR1R2, Z’; R1 = H; R2 = Ph; R5 = various substituents, inc, heterocycles; R6 = OH, NH2, substituted amino, (un)substituted alkyl; n = 0, 1, 2; m = 1, 2, 3; dashed line = single or double bond], their stereoisomers and pharmaceutical medically acceptable salts and prodrugs. Thus, N-(3-ethynylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine hydrochloride II·HCl was prepared from 4-chloro-7H-pyrrolo[2,3-d]pyrimidine via amination with (3-aminophenyl)acetylene in pyridine followed by treatment with HCl in MeOH. These compounds inhibit the receptor tyrosine kinase enzymes and thus, they are able to selectively prevent the multiplication of breast cancer cells (no data). On the basis of this, they can be used to treat different hyperproliferative diseases, such as cancer of the lung, bladder, stomach, pancreas, liver, kidney, large intestine and rectum, as well as gynecol. cancers. In addition, they are suitable for the treatment of other non-cancerous hyperproliferative diseases, such as psoriasis, or non-malignant prostate hypertrophy. The invention also includes the pharmaceutical products that contain effectives doses of the general formula compounds as their active component, and the new intermediate products, which can be applied during the synthesis of the compounds according to the invention. The experimental process involved the reaction of 6-Chloro-2,3-dihydro-1H-indole(cas: 52537-00-5).SDS of cas: 52537-00-5
The Article related to fused pyrimidine derivative preparation antiproliferative, psoriasis medicinal fused pyrimidine derivative, prostate hypertrophy medicinal fused pyrimidine derivative, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.SDS of cas: 52537-00-5
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles