Indole derivatives. XCIX. Reaction of indoles with chloroacetic acids was written by Avramenko, V. G.;Nazina, V. D.;Levinova, N. N.;Plutitskii, D. N.;Suvorov, N. N.. And the article was included in Khimiya Geterotsiklicheskikh Soedinenii in 1974.Formula: C10H8ClNO2 This article mentions the following:
The indoles I (R = H, Me, Ph; R1 = H, Cl, MeO, HO) were condensed with ClCH2CO2H in aqueous KOH at 240-50闂?and 5 atm to give the indoleacetates II. Similarly, Cl2CHCO2H and HOCH2CO2Et reacted with 1H-indole (III) to give II (R = R1 = H) in 91.5% and 46.3% yield, resp. Condensation of III with PhCH2Cl gave 21% 3-benzyl-1H-indole. In the experiment, the researchers used many compounds, for example, 2-(5-Chloro-1H-indol-3-yl)acetic acid (cas: 1912-45-4Formula: C10H8ClNO2).
2-(5-Chloro-1H-indol-3-yl)acetic acid (cas: 1912-45-4) belongs to indole derivatives. In addition to tryptophan, indigo, and indoleacetic acid, numerous compounds obtainable from plant or animal sources contain the indole molecular structure. In addition to indole, the strain-release chemistry worked for numerous substrates including amines, alcohols, thiols, carboxylic acids, imidazoles, and pyrazoles.Formula: C10H8ClNO2
Referemce:
Indole alkaloid derivatives as building blocks of natural products from闂佽壈浜崹淇沜illus thuringiensis闂佽壈浜粋鍧闂佽壈浜崹淇沜illus velezensis闂佽壈浜粋鍧 their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles