With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1075-35-0,5-Chloro-2-methylindole,as a common compound, the synthetic route is as follows.
10305] A 50 mE autoclave was charged with 6.3 mg (0.01 mmol, S/C100) of RuBF4((S,S)-N-Me-Msdpen) (p-cymene) obtained in Synthesis Example 18 serving as a catalyst, 0.16 12 g (1 mmol) of 5-chloro-2-methylindole, and 1.2 mE of HFIP, and the reaction was allowed to proceed at30 C. for 20 hours under a hydrogen pressure of 5 MPa. The conversion and the optical purity determined by GC analysis were 99.1% cony. (conversion) and 94.3% cc (optical purity)., 1075-35-0
The synthetic route of 1075-35-0 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; TAKASAGO INTERNATIONAL CORPORATION; TOUGE, Taichiro; NARA, Hideki; (32 pag.)US2016/347678; (2016); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles