With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.169674-01-5,5,6-Difluoroindole,as a common compound, the synthetic route is as follows.
23a) 5,6-Difluoro-1H-indole-3-carbaldehyde Phosphoryl cloride (22.03 g, 143.67 mmol) was added drop wise to an ice-cold N,N-dimethylformamide (DMF) (19.10 g, 261.22 mmol) and the mixture was stirred for 0.5 h at 0-5 C and for 1 h at room temperature. Then the mixture was cooled to 0-5 C and a solution of 5,6-difluoro-1H-indole (20.00 g, 130.61 mmol) in DMF (20 g) was added drop wise. The resulting mixture was stirred for 0.5 h at 0-5 C and for 15 h at room temperature. The mixture was poured onto chopped ice (200 g) and alkalinized with NaOH to pH=10. The crystalline product was filtered off, washed with water and dried to provide the title comound (22.72 g, 96.01 %).
169674-01-5, The synthetic route of 169674-01-5 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Bayer Schering Pharma Aktiengesellschaft; EP1932831; (2008); A1;,
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