With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.26340-49-8,2-Iodo-1H-indole,as a common compound, the synthetic route is as follows.
To a solution of 6 (6.97 g, 28.68 mmol) in CH2Cl2 (96 mL) at 0 C was added methyl vinyl ketone(4.02 g, 57.35 mmol) and InCl3 (0.32 g, 1.45 mmol). The mixture was stirred at 0 C for 1 h and warmedto RT. After 3 h, the reaction mixture was quenched with sat. aq. NaHCO3 (80 mL) and extracted withCH2Cl2 (2 x 80 mL). The organic layers were combined, washed with brine (80 mL), dried over MgSO4,and concentrated in vacuo. The residue was purified by recrystallization from hexane/CH2Cl2 (5:1, 30mL) to afford 7 (7.38 g, 82% yield) as a light yellow crystal. The filtrate was concentrated in vacuo andthe residue was purified by flash chromatography (silica gel, hexane/AcOEt = 6:1) to afford 7 (0.75 g,8% yield) as a light yellow crystal. Keto indole 7 was prepared in total 90 % yield.
26340-49-8, The synthetic route of 26340-49-8 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Miyamoto, Hiroshi; Hirano, Tomohiro; Okawa, Yoichiro; Nakazaki, Atsuo; Kobayashi, Susumu; Tetrahedron; vol. 69; 45; (2013); p. 9481 – 9493;,
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