With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.343-90-8,1-(5-Fluoro-1H-indol-3-yl)-N,N-dimethylmethanamine,as a common compound, the synthetic route is as follows.
General procedure: To a solution of gramine[1] (8.00 mmol) and AcOH (114 muL, 2.00 mmol) in THF (10 mL) a solution of dimethylsulphate (3.79 mL, 40 mmol) and AcOH (114 muL, 2.00 mmol) in THF (8 mL) was added at 0 C dropwise. After stirringfor 1 h, Et2O (40 ml) was added and the reaction mixture was cooled to -18 C, precipitates were filtered, washed with Et2O (3*30 mL), dried over P2O5 in vacuum to afford gramine methosulfate derivative., 343-90-8
Big data shows that 343-90-8 is playing an increasingly important role.
Reference：
Article; Reinfelds, Matiss; Kalinins, Konstantins; Katkevica, Dace; Zemribo, Ronalds; Katkevics, Martins; Tetrahedron Letters; vol. 56; 43; (2015); p. 5882 – 5885;,
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