Chemistry, like all the natural sciences, begins with the direct observation of nature— in this case, of matter.501-98-4, Name is Trans-4-Hydroxycinnamic Acid, SMILES is O=C(O)/C=C/C1=CC=C(O)C=C1, belongs to indole-building-block compound. In a document, author is Bonandi, Elisa, introduce the new discover, Category: indole-building-block.
The aza-alkylation reaction at indole’s C3 position allows the introduction of a differently substituted aminomethyl group, with the formation of a new stereogenic centre. The reaction involves essentially three different partners: an indole, aldehyde and amine. The formation of the reactive iminium species can be catalyzed by metals, Bronsted acids, Lewis acids or organocatalysts. The stereoselective reaction is feasible with satisfactory outcomes. This review summarizes the recent (2000-2019) meaningful papers in which the in-depth study and exploitation of this reactivity are reported.
The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 501-98-4 is helpful to your research. Category: indole-building-block.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles