659737-57-2, 6-Hydroxyisoindolin-1-one is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
l,l’-(Azodicarbonyl)dipiperidine (252 mg, 1.0 mmol) was added to a solution of (+/-)-trans- fert-butyl 3-(hydroxymethyl)-4-(4-methoxyphenyl)pyrrolidine-l-carboxylate [(+/-)B6, 160 mg, 0.52 mmol], 6-hydroxyisoindolinone (82 mg, 0.55 mmol) and tributylphosphine (0.37 mL, 1.5 mmol) in anhydrous tetrahydrofuran (12 mL) at 0 C under nitrogen, after which the mixture was slowly warmed to room temperature, stirring for a total of 12 h. The mixture was treated with diethyl ether (60 mL) and the solids were removed by filtration under reduced pressure. The filtrate solvents were removed under reduced pressure and the residue was purified by flash column chromatography on silica gel, eluting with dichloromethane/methanol (9: 1), to afford (+/-)-trans-tert-bu y 4-(4-methoxyphenyl)-3-{[(3- oxoisoindolin-5-yl)oxy]methyl}pyrrolidine-l-carboxylate [(+/-)B8] as a white solid (110 mg, 48%): LCMS (M+H) 439., 659737-57-2
659737-57-2 6-Hydroxyisoindolin-1-one 11528364, aindole-building-block compound, is more and more widely used in various fields.
Reference£º
Patent; TREVENA, INC.; CROMBIE SPEERSCHNEIDER, Aimee; YAMASHITA, Dennis SHINJI; PITIS, Philip Michael; HAWKINS, Michael John; LIU, Guodong; MISKOWSKI DAUBERT, Tamara Ann; YUAN, Catherine C.K.; BORBO KARGBO, Robert; HERR, Robert Jason; ROMERO, Donna; (125 pag.)WO2018/152293; (2018); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
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