With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.90271-86-6,5-Bromo-3-cyanoindole,as a common compound, the synthetic route is as follows.
General procedure: To a cold solution of the appropriate indoles 4a-d (4.2 mmol) in anhydrous DMF (7.8 mL) NaH(60% suspension in mineral oil, 6.3 mmol, 0.25 g) was added. After 30 min stirring at room temperature,tert-butyl (2-bromoethyl)carbamate [42] (6.3 mmol, 1.4 g) was added. The reaction mixture was heatedat 60 C for 24 h. After cooling, the mixture was poured into ice-water and extracted with ethyl acetate(3 20 mL). The organic phases were dried (anhydrous Na2SO4) and evaporated under reducedpressure. The residue was purified by column chromatography using petroleum ether/ethyl acetate(70/30) (for 5b-d) or petroleum ether/ethyl acetate (50/50) (for 5a) as eluent., 90271-86-6
As the paragraph descriping shows that 90271-86-6 is playing an increasingly important role.
Reference£º
Article; Carbone, Anna; Parrino, Barbara; Cusimano, Maria Grazia; Spano, Virginia; Montalbano, Alessandra; Barraja, Paola; Schillaci, Domenico; Cirrincione, Girolamo; Diana, Patrizia; Cascioferro, Stella; Marine Drugs; vol. 16; 8; (2018);,
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