Authors Jordan, A; Denton, RM; Sneddon, HF in AMER CHEMICAL SOC published article about WITTIG; CHLORIDES; REAGENT; OXIDE in [Jordan, Andrew; Denton, Ross M.] Univ Nottingham, GlaxoSmithKline Carbon Neutral Lab Sustainable Ch, Jubilee Campus, Nottingham NG7 2GA, England; [Sneddon, Helen F.] GSK, Med Res Ctr, Stevenage SG1 2NY, Herts, England in 2020.0, Cited 31.0. Formula: C7H8O. The Name is Benzyl Alcohol. Through research, I have a further understanding and discovery of 100-51-6
Herein, we report a green, chromatography-free Appel chlorination and bromination in both catalytic and stoichiometric form. Improved sustainability was achieved via the effective replacement of chlorinated solvents with dimethyl carbonate and the use of triphenylphosphine oxide (PPh3O) as a recyclable organocatalyst. The substrate scope of this halogenated solvent-free reaction was shown to be analogous to a contemporary methodology, and removal and recovery of PPh3O from the desired products were effectively demonstrated. Investigations into the catalytic cycle were conducted, and REACT-IR was demonstrated to be an effective method of reaction monitoring in situ. Optimized methodology was applied to the synthesis of 1-bromo-4-(1-bromoethyl)benzene, a key building block employed during the discovery of a GSK fatty acid synthase inhibitor.
About Benzyl Alcohol, If you have any questions, you can contact Jordan, A; Denton, RM; Sneddon, HF or concate me.. Formula: C7H8O
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles