Synthesis and antitumor activity of 5伪, 8伪-peroxide steroid derivatives containing dihydrazone unit was written by Bu, Ming;You, Dan;Zhang, Song;Chen, Zhe. And the article was included in Huaxue Shiji in 2019.Formula: C9H6ClNO This article mentions the following:
Using dehydroepiandrosterone (DHEA) as staring material, five steroidal endoperoxide derivatives with different indole side chain structures had been synthesized, and the structures were confirmed by MS, 1HNMR and 13CNMR. The antiproliferative activity was evaluated against human liver carcinoma cells (HepG2), human breast cancer cells (MCF-7) and normal kidney epithelial cells (293 T). The results showed that 5伪,8伪-epidioxy-17-(5-fluoro-indol-3-ylmethylene) hydrazonoandrostan-3尾-ol and 5伪,8伪-epidioxy-17-(5-chloro-indol-3-ylmethylene) hydrazonoandrostan-3尾-ol had significant inhibitory activity to the tested cancer cells. In the experiment, the researchers used many compounds, for example, 5-Chloroindole-3-carboxaldehyde (cas: 827-01-0Formula: C9H6ClNO).
5-Chloroindole-3-carboxaldehyde (cas: 827-01-0) belongs to indole derivatives. Indole, first isolated in 1866, and it is commonly synthesized from phenylhydrazine and pyruvic acid, although several other procedures have been discovered. More than 200 indole derivatives have already been marketed as drugs or are under advanced stages of clinical trials.Formula: C9H6ClNO
Referemce:
Indole alkaloid derivatives as building blocks of natural products from聽Bacillus thuringiensis聽and聽Bacillus velezensis聽and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles