Electric Literature of C8H6FNIn 2019 ,《Cross-dehydrogenative coupling of secondary benzylic ethers with indoles and pyrroles》 appeared in Tetrahedron Letters. The author of the article were Cao, Min; Mao, Ying; Huang, Jiancheng; Ma, Yudao; Liu, Lei. The article conveys some information:
The first cross-dehydrogenative coupling of secondary benzylic ethers with indoles and pyrroles for tertiary ether construction was described. A broad range of α-aryl substituted isochromans react with a variety of electronically varied indoles and pyrroles smoothly under mild metal-free conditions in high efficiency. In addition, the catalytic asym. variant was preliminarily explored and corresponding tertiary ether was obtained in 69% ee.5-Fluoro-1H-indole(cas: 399-52-0Electric Literature of C8H6FN) was used in this study.
5-Fluoro-1H-indole(cas: 399-52-0) is a member of aromaticfluorinated building blocks. Depending on which substituents are present, fluoroaromatic intermediates can be converted into fluorinated or fluorine-free commercial end products.Fluorine-containing aromatics have been incorporated into drugs (hypnotics, tranquilizers, antiinflammatory agents, analgesics, antibacterials).Electric Literature of C8H6FN
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles