Dobbs, Adrian published 《Total Synthesis of Indoles from Tricholoma Species via Bartoli/Heteroaryl Radical Methodologies》 in 2001. The article was appeared in 《Journal of Organic Chemistry》. They have made some progress in their research.Application In Synthesis of 7-Bromo-4-methyl-1H-indole The article mentions the following:
The Bartoli reaction of o-bromonitrobenzene with simple vinyl Grignard reagents was performed yielding a range of complex 7-bromo-substituted indoles followed by radical reduction using Bu3Sn/AIBN in toluene to give 7-unsubstituted indoles in near quant. yields. The total synthesis of three indole alkaloids I (R = H, OH, OMe) was then achieved via this Bartoli synthesis/heteroaryl radical reduction approach. To complete the study, the researchers used 7-Bromo-4-methyl-1H-indole (cas: 165669-07-8) .
Application In Synthesis of 7-Bromo-4-methyl-1H-indoleIn addition to tryptophan, indigo, and indoleacetic acid, numerous compounds obtainable from plant or animal sources contain the indole molecular structure. The best-known group of these compounds is the indole alkaloids, members of which have been isolated from plants representing more than 30 families.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles