Category: 100-83-4

Santos, FA; Tondato, WN; Parreira, RLT; Orenha, RP; Lourenco, LCL; de Laurentiz, RD in [Santos, Fernanda Amorim; Tondato, Wellington Negri; de Laurentiz, Rosangela da Silva] Univ Estadual Paulista, Dept Fis & Quim, UNESP, BR-15385000 Ilha Solteira, SP, Brazil; [Tame Parreira, Renato Luis; Orenha, Renato Pereira; Leite Lourenco, Luiz Carlos] Univ Franca, Nucleo Pesquisas Ciencias Exatas & Tecnol, Franca, SP, Brazil published Synthesis and luminescent properties of new naphthoquinoline lactone derivatives in 2020.0, Cited 43.0. Quality Control of 3-Hydroxybenzaldehyde. The Name is 3-Hydroxybenzaldehyde. Through research, I have a further understanding and discovery of 100-83-4.

The multicomponent reaction between tetronic acid (1), 2-aminoanthracene (2) and aromatic aldehydes (3) and the subsequent addition of DDQ produced a series of naphtho [2,3-f]quinoline lactone derivatives (5) in good yield. UV-Vis and fluorescence spectra of these derivatives are described. The optical absorption and emission properties of the compounds were studied in different solvents and pH. The results show that the naphthoquinoline derivatives have emission bands of 453-517 nm and one of them, compound 5d, had an unexpected bathochromic shift (597 nm) caused by an excited-state intramolecular proton transfer (ESIPT). The luminescent properties of 5d in different solvents and pH, although preliminary, indicate the potential use of this compound as a chemical sensor.

Quality Control of 3-Hydroxybenzaldehyde. Welcome to talk about 100-83-4, If you have any questions, you can contact Santos, FA; Tondato, WN; Parreira, RLT; Orenha, RP; Lourenco, LCL; de Laurentiz, RD or send Email.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Novel antiproliferative agents bearing morpholinopyrimidine scaffold as PI3K inhibitors and apoptosis inducers; design, synthesis and molecular docking WOS:000567809600001 published article about FEATURING MORPHOLINE MOIETY; NATIONAL-CANCER-INSTITUTE; BIOLOGICAL EVALUATION; PHOSPHOINOSITIDE 3-KINASE; COLORIMETRIC ASSAY; DRUG DISCOVERY; CELL-CYCLE; PI3K-ALPHA; CYTOTOXICITY; CHEMOTHERAPY in [Helwa, Amira A.] Misr Univ Sci & Technol, Coll Pharmaceut Sci & Drug Mfg, Dept Organ Pharmaceut Chem, POB 77, 6th Of October City, Egypt; [El-Dydamony, Nehad M.] Misr Univ Sci & Technol, Coll Pharmaceut Sci & Drug Mfg, Dept Pharmaceut Chem, 6th Of October City, Egypt; [Radwan, Rasha A.] Sinai Univ, Fac Pharm & Pharmaceut Ind, Dept Biochem, Kantara Branch, New City, El Ismailia, Egypt; [Abdelraouf, Sahar M.] Misr Int Univ, Fac Pharm, Dept Biochem, Cairo, Egypt; [Abdelnaby, Rana M.] Heliopolis Univ, Fac Pharm, Dept Pharmaceut Chem, Cairo, Egypt in 2020.0, Cited 46.0. Application In Synthesis of 3-Hydroxybenzaldehyde. The Name is 3-Hydroxybenzaldehyde. Through research, I have a further understanding and discovery of 100-83-4

Two series of novel morpholinopyrimidine derivatives were synthesized and screened for their in-vitro cytotoxic activity against 60 tumor cell line by the National Cancer Institute, USA. The in-vitro cytotoxic IC50 values for the most active compounds 6e, 6g, and 6l against the most sensitive cell line leukemia SR were estimated (IC50 = 0.76, 13.59, and 4.37 uM, respectively). To investigate their PI3K enzyme inhibition activity, the assay was done on Class IA (alpha, beta, & delta) isoforms. The IC50 values were very promising: compound [6e = 11.73 (alpha), 6.09 (beta), 11.18 (delta)], compound [6g = 8.43 (alpha), 15.84 (beta), 30.62 (delta)], and compound [6l = 13.98 (alpha), 7.22 (beta), 10.94 (delta)], compared to the reference compound LY294002 = 6.28 (alpha), 4.51 (beta), 4.60 (delta) uM, respectively. Moreover, cell cycle analysis and annexin V-FITC staining were done on Leukemia SR, there was arrest at G2/M phase and apoptosis was induced. Finally, docking study was performed to analyze the interactive mode of these derivatives in PI3K alpha ATP-binding site. These outcomes proved that compounds 6e, 6g, and 6l are potential leads for further optimization as antileukemic agents.

Bye, fridends, I hope you can learn more about C7H6O2, If you have any questions, you can browse other blog as well. See you lster.. Application In Synthesis of 3-Hydroxybenzaldehyde

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Authors Davoodi, F; Dekamin, MG; Alirezvani, Z in WILEY published article about PERIODIC MESOPOROUS ORGANOSILICA; ON-WATER SYNTHESIS; ONE-POT SYNTHESIS; MULTICOMPONENT SYNTHESIS; EXPEDITIOUS SYNTHESIS; AQUEOUS-MEDIUM; NANOPARTICLES; INHIBITORS; NANOSHEETS; CARBOCATALYSIS in [Davoodi, Farahnaz; Dekamin, Mohammad G.; Alirezvani, Zahra] Iran Univ Sci & Technol, Dept Chem, Pharmaceut & Heterocycl Cpds Res Lab, Tehran 1684613114, Iran in 2019.0, Cited 85.0. Recommanded Product: 100-83-4. The Name is 3-Hydroxybenzaldehyde. Through research, I have a further understanding and discovery of 100-83-4

Zinc oxide-decorated superparamagnetic silica attached to graphene oxide (Fe3O4/SiO2/PTS-GO-ZnO), as a novel nanocomposite, was designed, and its core-shell structure was appropriately characterized by different spectroscopy or microscopy methods and thermal techniques as well as measuring of its porosity and magnetic properties. The catalytic activity of Fe3O4/SiO2/PTSGO-ZnO, as a reusable heterogeneous catalyst, was investigated for efficient one-pot multi-component synthesis of medicinally important functionalized 2-amino-6-(2-oxo-2H-chromen-3-yl)-4-arylnicotinonitrile derivatives. The significant features of the present procedure are mild reaction conditions, low loading of the catalyst, high to quantitative yields of the desired products, avoiding the use of toxic heavy metals or solvents, simple isolation and purification of the products, and stability as well as reusability of the catalyst after at least six consecutive runs.

Recommanded Product: 100-83-4. Welcome to talk about 100-83-4, If you have any questions, you can contact Davoodi, F; Dekamin, MG; Alirezvani, Z or send Email.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

I found the field of Chemistry very interesting. Saw the article Ionic liquid-assisted synthesis of dihydropyrimidin(thi)one Biginelli adducts and investigation of their mechanism of urease inhibition published in 2019.0. HPLC of Formula: C7H6O2, Reprint Addresses de Fatima, A (corresponding author), Univ Fed Minas Gerais, Dept Quim, GEQOB, Belo Horizonte, MG, Brazil.. The CAS is 100-83-4. Through research, I have a further understanding and discovery of 3-Hydroxybenzaldehyde

Twenty-six Biginelli adducts were synthesized through an ionic liquid-assisted synthesis with up to 92% yield. Sixteen of these Biginelli adducts were then assayed to determine their antiureolytic activity against purified urease from jack beans. The substances BA7-S, BA9-S and BA11-S were shown to be as efficient inhibitors as hydroxyurea, a positive control used in in vitro screening assay against urease. Fluorescence studies revealed that BA7-S, BA9-S, BA11-S and BA5-S possessed high binding constant values of 5.95, 6.72, 4.55, and 4.28 M-1, respectively, while BAS12-S, without substituents, showed a low value of log K-b = 2.16 M-1. In addition, in the most thermodynamically favorable BA5-S and BA7-S urease complexes, the corresponding Biginelli adducts were capable of interacting with the active site of urease through non-ionic interactions, such as hydrophobic interactions, or hydrogen and van der Waals interactions, respectively. In silico studies also supported that the BAs interact with the active site, confirming the fluorescence and kinetic assay studies, which clearly indicate that BA5-S and BA7-S are competitive inhibitors (K-i = 0.96 and 0.57 mM, respectively). In silico studies also showed that the substituents in the aromatic ring interact with Ni atoms to form a stable complex.

Welcome to talk about 100-83-4, If you have any questions, you can contact Braga, AC; Silva, TF; Maciel, TMS; da Silva, ECD; Da Silva, EF; Modolo, LV; Figueiredo, IM; Santos, JCC; de Aquino, TM; de Fatima, A or send Email.. HPLC of Formula: C7H6O2

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Design and Synthesis of Novel Nordihydroguaiaretic Acid (NDGA) Analogues as Potential FGFR1 Kinase Inhibitors With Anti-Gastric Activity and Chemosensitizing Effect WOS:000576019000001 published article about GASTRIC-CANCER; GENE AMPLIFICATION; BREAST-CANCER; PHASE-I; GROWTH; DISCOVERY; TERAMEPROCOL; CHALLENGES; AGENTS in [Chen, Qian; Li, Wulan] Wenzhou Med Univ, Affiliated Hosp 1, Wenzhou, Peoples R China; [Chen, Qian; Zhu, Min; Xie, Jingwen; Dong, Zhaojun; Khushafah, Fatehi; Yun, Di; Fu, Weitao; Wei, Tao; Liu, Zhiguo; Qiu, Peihong; Wu, Jianzhang; Li, Wulan] Wenzhou Med Univ, Coll Pharmaceut Sci, Chem Biol Res Ctr, Wenzhou, Peoples R China; [Wang, Ledan] Wenzhou Med Univ, Affiliated Hosp 2, Dept Gynecol & Obstet, Wenzhou, Peoples R China in 2020.0, Cited 49.0. The Name is 3-Hydroxybenzaldehyde. Through research, I have a further understanding and discovery of 100-83-4. Application In Synthesis of 3-Hydroxybenzaldehyde

Aberrant fibroblast growth factor receptor-1 (FGFR1), a key driver promoting gastric cancer (GC) progression and chemo-resistance, has been increasingly recognized as a potential therapeutic target in GC. Hereon, we designed and synthesized a series of asymmetric analogues usingAf23and NDGA as lead compounds by retaining the basic structural framework (bisaryl-1,4-dien-3-one) and the unilateral active functional groups (3,4-dihydroxyl). Thereinto,Y14showed considerable inhibitory activity against FGFR1. Next, pharmacological experiments showed thatY14could significantly inhibit the phosphorylation of FGFR1 and its downstream kinase AKT and ERK, thus inhibiting the growth, survival, and migration of gastric cancer cells. Furthermore, compared with 5-FU treatment alone, the combination ofY14and 5-FU significantly reduced the phosphorylation level of FGFR1, and enhanced the anti-cancer effect by inhibiting the viability and colony formation in two gastric cancer cell lines. These results confirmed thatY14exerted anti-gastric activity and chemosensitizing effect by inhibiting FGFR1 phosphorylation and its downstream signaling pathwayin vitro. This work also provides evidence thatY14, an effective FGFR1 inhibitor, could be used alone or in combination with chemotherapy to treat gastric cancer in the future.

About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Chen, Q; Zhu, M; Xie, JW; Dong, ZJ; Khushafah, F; Yun, D; Fu, WT; Wang, LD; Wei, T; Liu, ZG; Qiu, PH; Wu, JZ; Li, WL or concate me.. Application In Synthesis of 3-Hydroxybenzaldehyde

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

In 2019.0 POLYCYCL AROMAT COMP published article about RECYCLABLE CATALYST; IONIC LIQUID; DERIVATIVES; ANTIFUNGAL in [Fatahpour, Maryann; Hazeri, Nourallah; Maghsoodlou, Malek Taher] Univ Sistan & Baluchestan, Fac Sci, Dept Chem, POB 98135-674, Zahedan, Iran; [Lashkari, Mojtaba] Velayat Univ, Fac Sci, Iranshahr, Iran in 2019.0, Cited 33.0. The Name is 3-Hydroxybenzaldehyde. Through research, I have a further understanding and discovery of 100-83-4. Recommanded Product: 3-Hydroxybenzaldehyde

Lactic acid, as a biological, eco-friendly, and inexpensive compound, efficiently catalyzed the synthesis of 8,10-dimethyl-12-aryl-12H-naphtho[1 ‘,2 ‘:5,6]pyrano[2,3-d] pyrimidine-9,11-dione derivatives by an efficient one-pot, three-component reaction between aromatic aldehydes, beta-naphthol, and 6-amino-1,3-dimethyl uracil at 100 degrees C under solvent-free conditions. The benefits of the reaction are good yields, simple procedure, short reaction time, easy work-up, and cleaner reaction profiles.

Recommanded Product: 3-Hydroxybenzaldehyde. Bye, fridends, I hope you can learn more about C7H6O2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Design, crystal structures and sustainable synthesis of family of antipyrine derivatives: Abolish to bacterial and parasitic infection WOS:000492858500061 published article about BIOLOGICAL EVALUATION; MOLECULAR DOCKING; ORGANOSILATRANES; CHEMISTRY; AGENTS in [Singh, Gurjaspreet; Satija, Pinky; Sahoo, Subash Chandra] Panjab Univ, Dept Chem, Chandigarh 160014, India; [Singh, Baljinder] Panjab Univ, Dept Biotechnol, Chandigarh 160014, India; [Sinha, Shweta; Sehgal, Rakesh] PGIMER, Dept Med Parasitol, Chandigarh 160012, India in 2020.0, Cited 25.0. The Name is 3-Hydroxybenzaldehyde. Through research, I have a further understanding and discovery of 100-83-4. Safety of 3-Hydroxybenzaldehyde

This work explores the facile synthesis of a series of antipyrine acetylinic framework (3a-3h). The newly synthesized compounds are recognized by IR, NMR (H-1, C-13), X-ray diffraction. This collection played indispensable role in the development of biologically active agents. Our goal is to enable adoption of green chemistry within the pharmaceutical industry for the benefit of society, industry and the environment. This work articulates a new possible scaffold for drug discovery against protozoal pathogens (Entamoeba histolytica and Giardia lamblia) and bacterial strain (Staphylococcus aureus, Vibrio cholera, E. coli, Bacillus subtillus). The purpose of the present undertaking is to put low price anti parasitic drug using green technology. It is envisaged that the alliance of anti pyrine derivative and acetylene framework into a single scaffold boosts the effectiveness of anti bacterial as well as anti-parasitic treatment and may be vital for meeting future challenges in medicinal world. (C) 2019 Elsevier B.V. All rights reserved.

Safety of 3-Hydroxybenzaldehyde. Bye, fridends, I hope you can learn more about C7H6O2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Formula: C7H6O2. Recently I am researching about METAL-ORGANIC FRAMEWORKS; ONE-POT SYNTHESIS; MULTICOMPONENT SYNTHESIS; 3-COMPONENT SYNTHESIS; NANOPARTICLES; ANTIOXIDANT; ACID; MOFS, Saw an article supported by the Islamic Azad University, Qom Branch, Qom, I. R. Iran [2014-13929]. Published in ELSEVIER in AMSTERDAM ,Authors: Ghaffarian, F; Ghasemzadeh, MA; Aghaei, SS. The CAS is 100-83-4. Through research, I have a further understanding and discovery of 3-Hydroxybenzaldehyde

( )Curcumin (bis-alpha,beta-unsaturated beta-diketone) is a low molecular weight hydrophobic polyphenol isolated from Curcuma longa. Curcumin has attracted significant recent consideration due to its medicinal and pharmacological properties. In this research pyrano[2,3-d]pyrimidine-2,4(3H)-dione derivatives were prepared in excellent yields and short reaction times by a one-pot multi-component cyclocondensation of curcumin, substituted aromatic aldehydes and barbituric acid in the presence of CoFe2O4@OCMC@Cu(BDC) nanostructure as an effective and robust catalyst. The CoFe2O4 functionalized OCMC@Cu(BDC) is introduced as a new, strong and efficient catalyst for the synthesis of a variety of heterocyclic compounds. The catalyst was perfectly characterized by various spectroscopy methods such as Fouriertransform infrared spectroscopy (FT-IR), Energy-dispersive X-ray (EDX), Scanning electron microscope (SEM), X-ray diffraction (XRD) and N2 adsorption-desorption isotherm (BET). Furthermore, the heterocyclic compounds were fully characterized by different spectral techniques including FT-IR, (HNMR)-H-1, (CNMR)-C-13. The magnetic catalyst could be easily recycled and reused for seven runs with a slightly decrease in its activity. (C) 2019 Elsevier B.V. All rights reserved.

Formula: C7H6O2. Welcome to talk about 100-83-4, If you have any questions, you can contact Ghaffarian, F; Ghasemzadeh, MA; Aghaei, SS or send Email.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recommanded Product: 3-Hydroxybenzaldehyde. Recently I am researching about IRIDIUM-CATALYZED HYDROGENATION; ENANTIOSELECTIVE SYNTHESIS; HETEROAROMATIC-COMPOUNDS; QUINOLINES, Saw an article supported by the National Science FoundationNational Science Foundation (NSF) [CHE-1350060]. Published in ROYAL SOC CHEMISTRY in CAMBRIDGE ,Authors: Sun, SY; Nagorny, P. The CAS is 100-83-4. Through research, I have a further understanding and discovery of 3-Hydroxybenzaldehyde

New and readily available chiral SPIROL-based diphosphinite ligands (SPIRAPO) have been prepared and employed for iridium-catalyzed asymmetric hydrogenations of quinolines, quinoxalines and 2H-1,4-bezoxazin-2-ones. While the structurally similar (R,R,R)-SPIRAPO and (R)-SPINOL-based phosphinites were not the best ligands for these transformations, the (S,R,R)-diastereomer of SPIRAPO was found to be highly effective ligand for the reduction of 20 different heterocyclic systems with loadings as low as S/C = 10 000. This dearomatizative hydrogenation provided direct access to optically active tetrahydroquinolines in high enantioselectivities (up to 94% ee) and excellent yields (up to 99%), and was used to generate 1.75 g of natural alkaloid (-)-(R)-angustureine. This protocol was subsequently extended to achieve asymmetric hydrogenation of quinoxalines and 2H-1,4-benzoxazin-2-ones in good to excellent enantioselectivities.

Recommanded Product: 3-Hydroxybenzaldehyde. About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Sun, SY; Nagorny, P or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

In 2020 J CRYST GROWTH published article about SINGLE-CRYSTALS; DAST CRYSTALS; DERIVATIVES; GENERATION in [Cui, Qingtang; Zhong, Degao; You, Fei; Xu, Kai; Wang, Tianhua; Liu, Jiaojiao; Cao, Lifeng; Tang, Jie; Teng, Bing] Qingdao Univ, Coll Phys, Univ Ind Joint Ctr Ocean Observat & Broadband Com, Qingdao 266071, Peoples R China; [Li, Ruimao; Xu, Hui] CRYSTECH Inc, Qingdao 266107, Peoples R China; [Zhong, Degao; Cao, Lifeng; Tang, Jie; Teng, Bing] Qingdao Univ, Natl Demonstrat Ctr Expt Appl Phys Educ, Qingdao 266071, Peoples R China; [Zhong, Degao; Cao, Lifeng; Tang, Jie; Teng, Bing] Qingdao Univ, Shandong Prov Univ, Key Lab Optoelect Mat Phys & Devices, Qingdao 266071, Peoples R China; [Huang, Wanxia] Inst High Energy, Beijing Synchrotron Radiat Lab, Beijing 100039, Peoples R China in 2020, Cited 27. The Name is 3-Hydroxybenzaldehyde. Through research, I have a further understanding and discovery of 100-83-4. Safety of 3-Hydroxybenzaldehyde

High yield 3-hydroxy benzaldehyde-N-methyl 4-stilbazolium tosylate (3-HBST) was synthesized by optimizing the reaction temperature. High-quality bulk crystals of 3-HBST were grown by slow evaporation technique and spontaneous nucleation method, respectively. The crystal structure of 3-HBST was determined by single crystal X-ray diffraction (XRD) technique and belongs to monoclinic system. The defects of the 3-HBST crystals were observed by the synchrotron radiation X-ray topography. 3-HBST crystal remains stable until 305 degrees C, with a melting point of 214.1 degrees C from the TG-DTG and DSC techniques. The dielectric constant of 3-HBST crystal was also studied. The grown crystal had good optical transparency and the optical transmittance was investigated by UV-vis-NIR spectral analysis. Photoluminescence (PL) indicated green emission occurred at 478 nm. Based on the growth technical analysis and performance parameters measurements, 3-HBST crystal was verified to be a promising organic nonlinear optical crystal.

Welcome to talk about 100-83-4, If you have any questions, you can contact Cui, QT; Li, RM; Zhong, DG; You, F; Xu, K; Xu, H; Wang, TH; Liu, JJ; Cao, LF; Tang, J; Huang, WX; Teng, B or send Email.. Safety of 3-Hydroxybenzaldehyde

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles