Category: 100-83-4

Recently I am researching about SELECTIVE HDAC3 INHIBITORS; CANCER; FAMILY, Saw an article supported by the Science and Engineering Research Board, Department of Science and Technology (SERB-DST), New Delhi, IndiaDepartment of Science & Technology (India) [EMR/2016/001411]. Published in ROYAL SOC CHEMISTRY in CAMBRIDGE ,Authors: Hamoud, MMS; Pulya, S; Osman, NA; Bobde, Y; Hassan, AEA; Abdel-Fattah, HA; Ghosh, B; Ghanim, AM. The CAS is 100-83-4. Through research, I have a further understanding and discovery of 3-Hydroxybenzaldehyde. Quality Control of 3-Hydroxybenzaldehyde

Most of the FDA approved histone deacetylase inhibitors (HDACi) contain hydroxamate as the zinc binding group (ZBG). Hydroxamates form strong electrostatic metal chelation with divalent zinc present in HDAC. This strong zinc chelation leads to unwanted metabolic abnormalities. Therefore, the design of a non-hydroxamate moiety as a ZBG encourages medicinal chemistry researchers. Here, a series of nicotinamide derivatives have been designed and synthesized as HDACi. All compounds were tested for their inhibitory activities against pan HDACs (containing predominantly HDAC1 and HDAC2 isozymes) and against the HDAC3 isoform. Among these, compounds6band6nshowed comparable pan HDAC inhibitory activity (IC50= 4.648 mu M and IC50= 5.481 mu M, respectively) compared withBG45(IC50= 5.506 mu M). Compound6bexhibited the best potency against HDAC3 with IC50= 0.694 mu M. In addition, the anti-proliferative activity of the synthesized compounds6a-swas evaluated against three different cancer cell lines including B16F10, MCF-7, and A549. Compound6bdisplayed the highest anti-proliferative potency (IC50= 4.66 mu M in B16F10 cell lines) and compounds6b,6c,6h,6i,6l,6m, and6nexhibited higher cytotoxicity against all cell lines compared with the referenceBG45. The selected potent compounds also displayed significant selectivity against cancer cell lines over normal human embryonic kidney (HEK-293) cell lines. The molecular modelling study displayed possible interactions between the most potent inhibitor6band HDAC3 active sites. Furthermore, the predictedin silicostudies of all target compounds revealed acceptable physicochemical properties and pharmacokinetic parameters.

Quality Control of 3-Hydroxybenzaldehyde. About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Hamoud, MMS; Pulya, S; Osman, NA; Bobde, Y; Hassan, AEA; Abdel-Fattah, HA; Ghosh, B; Ghanim, AM or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Formula: C7H6O2. Recently I am researching about BENZYL ALCOHOLS; ALDEHYDES; NANOPARTICLES; AMINES; GO; REARRANGEMENT; ESTERS, Saw an article supported by the DST-SERB; UGC New DelhiUniversity Grants Commission, India; CSIRCouncil of Scientific & Industrial Research (CSIR) – India. Published in SPRINGER in NEW YORK ,Authors: Dandia, A; Parihar, S; Saini, P; Rathore, KS; Parewa, V. The CAS is 100-83-4. Through research, I have a further understanding and discovery of 3-Hydroxybenzaldehyde

We describe an efficient, clean and metal-free procedure for the synthesis of amides via oxidative amidation of aldehydes with anilines using graphene oxide (GO) as a recyclable catalyst and KBrO3 as a mild oxidant in aqueous medium under microwave irradiation. GO nanosheets were prepared and characterized by XRD, TEM, SEM, and FT-IR, analyses. GO showed high compatibility with KBrO3 in water and offered high TOF value (1.30 x 10(-3) mol g(-1) min(-1)). GO oxygen functionalities catalyze the oxidative amidation effectively in mild condition with high recyclability. A plausible mechanism was proposed by the isolating the intermediate.

Welcome to talk about 100-83-4, If you have any questions, you can contact Dandia, A; Parihar, S; Saini, P; Rathore, KS; Parewa, V or send Email.. Formula: C7H6O2

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recommanded Product: 100-83-4. Tavakoli, F; Mamaghani, M; Sheykhan, M in [Tavakoli, Fateme; Mamaghani, Manouchehr; Sheykhan, Mehdi] Univ Guilan, Fac Sci, Dept Chem, POB 41335-1914, Rasht, Iran published Introduction of Ag/CuO/MCM-48 as an efficient catalyst for the one-pot synthesis of novel pyran-pyrrole hybrids in 2019.0, Cited 101.0. The Name is 3-Hydroxybenzaldehyde. Through research, I have a further understanding and discovery of 100-83-4.

Bimetallic silver and copper incorporated mesoporous MCM-48 (Ag/CuO/MCM-48) was synthesized by simple wet-impregnation method. The knowledge about its structural properties was gathered by means of Fourier transform-infrared, energy-dispersive X-ray, X-ray diffraction, field emission-scanning electron microscopy, transmission electron microscopy and Brunauer-Emmett-Teller analyses. The catalytic activity of Ag/CuO/MCM-48 was examined in the one-pot three-component reaction of 3-(1-methyl-1H-pyrrol-2-yl)-3-oxopropanenitrile, malononitrile and various aromatic aldehydes leading to novel pyran-pyrrole hybrid derivatives in reduced reaction times (5-10 min) and excellent yields (88-97%). Application of Ag/CuO/MCM-48 as a potent heterogeneous catalyst with good reusability up to five times, use of ethanol as an eco-compatible medium and chromatography-free work-up are some crucial green aspects of this procedure.

Recommanded Product: 100-83-4. Welcome to talk about 100-83-4, If you have any questions, you can contact Tavakoli, F; Mamaghani, M; Sheykhan, M or send Email.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

In 2020.0 BIOORG MED CHEM LETT published article about BIOLOGICAL EVALUATION; COMBRETASTATIN A-4; DERIVATIVES; ANALOGS; DESIGN; ANTIBACTERIAL; ANTITUMOR; HYBRIDS; GROWTH; APOPTOSIS in [Dofe, Vidya S.] Deogiri Coll, Dept Chem, Aurangabad 431005, Maharashtra, India; [Sarkate, Aniket P.; Karnik, Kshipra S.; Kale, Ishwari A.] Dr Babasaheb Ambedkar Marathwada Univ, Dept Chem Technol, Aurangabad 431004, Maharashtra, India; [Tiwari, Shailee, V] Durgamata Inst Pharm, Dept Pharmaceut Chem, Parbhani 431401, Maharashtra, India; [Lokwani, Deepak K.] RC Patel Inst Pharmaceut Educ & Res, Dept Pharmaceut Chem, Shirpur 425405, MS, India; [Dodamani, Suneel; Jalalpure, Sunil S.] KLE Acad Higher Educ & Res, Dr Prabhakar Kore Basic Sci Res Ctr, Belagavi 590010, Karnataka, India; [Jalalpure, Sunil S.] KLE Acad Higher Educ & Res, KLE Coll Pharm, Belagavi 590010, Karnataka, India; [Burra, Prasad V. L. S.] KLEF Univ, Dept Biotechnol, Vaddeswaram 522502, AP, India in 2020.0, Cited 49.0. The Name is 3-Hydroxybenzaldehyde. Through research, I have a further understanding and discovery of 100-83-4. SDS of cas: 100-83-4

In search of new active molecules against MCF-7, A549 and HepG2, tetrazole based pyrazoline and isoxazoline derivatives under both conventional and ultrasonic irradiation method were designed and efficiently synthesized. Structures of newly synthesized compounds 5a-h and 6a-h were characterized by H-1 NMR, C-13 NMR, MS and elemental analysis. Several derivatives were found to be excellent cytotoxic against MCF-7, A549 and HepG2 cell lines characterized by lower IC50 values (0.78-3.12 mu g/mL). Compounds 5b and 5c demonstrated an antiproliferative effect comparable to that of CA-4. Western blot analysis revealed that, reported compounds accumulate more tubulin in the soluble fraction. Docking studies suggested that, binding of these compounds mimics at the colchicine site of tubulin. In vitro study revealed that the tetrazole based pyrazolines and isoxazolines may possess ideal structural requirements for further development of novel therapeutic agents.

SDS of cas: 100-83-4. Welcome to talk about 100-83-4, If you have any questions, you can contact Dofe, VS; Sarkate, AP; Tiwari, SV; Lokwani, DK; Karnik, KS; Kale, IA; Dodamani, S; Jalalpure, SS; Burra, PVLS or send Email.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article A new method for the synthesis of chalcone derivatives promoted by PPh3/I(2)under non-alkaline conditions WOS:000590637100001 published article about SOLVENT-FREE CONDITIONS; EFFICIENT SYNTHESIS; HETEROGENEOUS CATALYST; BIOLOGICAL EVALUATION; ALDOL CONDENSATIONS; DESIGN; AGENTS; FLAVONOIDS; INHIBITORS; AMIDATION in [Xue, Kangsheng] Changchun Univ Chinese Med, Coll Pharm, Changchun, Peoples R China; [Sun, Guoxiang] Yancheng Inst Technol, Sch Chem & Chem Engn, Yancheng, Jiangsu, Peoples R China; [Zhang, Yanzhi; Chen, Xubing] Dali Univ, Coll Pharm, Dali, Peoples R China; [Zhou, Yang; Hou, Jinjun; Long, Huali; Zhang, Zijia; Lei, Min; Wu, Wanying] Chinese Acad Sci, Shanghai Res Ctr Modernizat Tradit Chinese Med, Shanghai Inst Mat Med, Natl Engn Lab TCM Standardizat Technol, Shanghai, Peoples R China; [Zhou, Yang; Hou, Jinjun; Long, Huali; Zhang, Zijia; Lei, Min; Wu, Wanying] Univ Chinese Acad Sci, Beijing, Peoples R China in 2021, Cited 61. The Name is 3-Hydroxybenzaldehyde. Through research, I have a further understanding and discovery of 100-83-4. Product Details of 100-83-4

A straightforward and general method has been developed for the synthesis of chalcone derivatives by a Claisen-Schmidt reaction in the presence of PPh3/I-2 in 1,4-dioxane under reflux temperatures. With the condensation of the aromatic ketone and aldehyde occurring at non-strongly alkaline conditions, our proposed method significantly expands the range of applicable substrates, especially for groups that are unstable under alkaline conditions.

Product Details of 100-83-4. About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Xue, KS; Sun, GX; Zhang, YZ; Chen, XB; Zhou, Y; Hou, JJ; Long, HL; Zhang, ZJ; Lei, M; Wu, WY or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Authors Xiong, W; Wang, XH; Shen, XY; Hu, CF; Wang, X; Wang, F; Zhang, GL; Wang, C in AMER CHEMICAL SOC published article about DIARYLPROLINOL SILYL ETHER; ENONE-OLEFIN; DEACTIVATION; DERIVATIVES; EPOXIDATION; MECHANISMS; SOLUTES; SALT in [Xiong, Wei; Wang, Xiaohong; Shen, Xianyan; Wang, Fei; Zhang, Guolin; Wang, Chun] Chinese Acad Sci, Chengdu Inst Biol, Chengdu 610041, Peoples R China; [Xiong, Wei; Wang, Xiaohong; Shen, Xianyan] Univ Chinese Acad Sci, Beijing 100049, Peoples R China; [Hu, Cuifang; Wang, Xin] Sichuan Univ, Coll Chem, Chengdu 610064, Peoples R China in 2020.0, Cited 47.0. Computed Properties of C7H6O2. The Name is 3-Hydroxybenzaldehyde. Through research, I have a further understanding and discovery of 100-83-4

A novel synthetic method for flavonol from 2′-hydroxyl acetophenone and benzaldehyde promoted by pyrrolidine under an aerobic condition in water is established. This protocol was supported by efficient synthesis of 44 common examples and three natural products. The alpha, beta-unsaturated iminium ion (enimine ion E) was proved to be the key intermediate in the reaction. (H2O)-O-18 and O-18(2) isotope tracking experiments demonstrated that both water and the aerobic atmosphere were necessary to ensure the transformation. The selectivity for flavonol or aurone was originated from solvent-triggered intermediates, which were determined by UV-visible spectra from isolated enimine. The phenol-iminium E-A is dominant in water and the ketoenamine intermediate E-B is prevalent in acetonitrile. In the presence of pyrrolidine and oxygen, E-A leads to flavonol through E-I, a zwitterionic-like phenoloxyl-iminium ion, following the key steps of cyclization and a [2 + 2] oxidation; E-B proceeds through path II, a radical process induced by photolysis of E-B with both pyrrolidine and oxygen, to afford aurone. Preliminary mechanistic studies are reported.

Computed Properties of C7H6O2. Bye, fridends, I hope you can learn more about C7H6O2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Name: 3-Hydroxybenzaldehyde. In 2019.0 BIOORG CHEM published article about HELICOBACTER-PYLORI UREASE; BIOLOGICAL EVALUATION; PROTEUS-MIRABILIS; BACTERIAL UREASE; DERIVATIVES; VISUALIZATION; INFECTIONS; CHEMISTRY; DESIGN in [Isaac, Ibanga Okon; Hameed, Abdul; Khan, Khalid Mohammed] Univ Karachi, Int Ctr Chem & Biol Sci, HEJ Res Inst Chem, Karachi 75270, Pakistan; [Al-Rashida, Mariya] A Chartered Univ, Dept Chem, Forman Christian Coll, Ferozepur Rd, Lahore 54600, Pakistan; [Rahman, Shafiq Ur; Iqbal, Jamshed] COMSATS Inst Informat Technol, Ctr Adv Drug Res, Abbottabad 22060, Pakistan; [Alharthy, Rima D.] King Abdulaziz Univ, Dept Chem Sci & Arts Coll, Rabigh Campus, Jeddah, Saudi Arabia; [Asari, Asnuzilawati] Univ Malaysia Terengganu, Sch Fundamental Sci, Kuala Nerus 21030, Terengganu, Malaysia; [Khan, Khalid Mohammed] Imam Abdulrahman Bin Faisal Univ, Inst Res & Med Consultat, Dept Clin Pharm, POB 31441, Dammam, Saudi Arabia in 2019.0, Cited 37.0. The Name is 3-Hydroxybenzaldehyde. Through research, I have a further understanding and discovery of 100-83-4.

Urease is a bacterial enzyme that is responsible for virulence of various pathogenic bacteria such as Staphylococcus aureus, Proteus mirabilis, Klebsiella pneumoniae, Ureaplasma urealyticum, Helicobacter pylori and Mycobacterium tuberculosis. Increased urease activity aids in survival and colonization of pathogenic bacteria causing several disorders especially gastric ulceration. Hence, urease inhibitors are used for treatment of such diseases. In search of new molecules with better urease inhibitory activity, herein we report a series of acridine derived (thio) semicarbazones (4a-4e, 6a-6l) that were found to be active against urease enzyme. Molecular docking studies were carried out to better comprehend the preferential mode of binding of these compounds against urease enzyme. Docking against urease from pathogenic bacterium S. pasteurii was also carried out with favorable results. In silico ADME evaluation was done to determine drug likeness of synthesized compounds.

Welcome to talk about 100-83-4, If you have any questions, you can contact Isaac, IO; Al-Rashida, M; Rahman, SU; Alharthy, RD; Asari, A; Hameed, A; Khan, KM; Iqbal, J or send Email.. Name: 3-Hydroxybenzaldehyde

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article A multifunctional triazine-based nanoporous polymer as a versatile organocatalyst for CO2 utilization and C-C bond formation WOS:000487669300023 published article about CATALYTIC CONVERSION; CYCLIC CARBONATES; REDUCTION; NITROGEN; CYCLOADDITION; IMIDAZOLIUM; FRAMEWORK; EPOXIDES; CAPTURE in [Sharma, Ruchi; Bansal, Ankushi; Mohanty, Paritosh] IIT Roorkee, Dept Chem, Funct Mat Lab, Roorkee 247667, Uttarakhand, India; [Ramachandran, C. N.] IIT Roorkee, Dept Chem, Theoret & Computat Chem Lab, Roorkee 247667, Uttarakhand, India in 2019.0, Cited 40.0. The Name is 3-Hydroxybenzaldehyde. Through research, I have a further understanding and discovery of 100-83-4. Formula: C7H6O2

A triazine-based nanoporous multifunctional polymer with a SA(BET) of 304 m(2) g(-1) has shown versatile catalytic activity in the conversion of CO2 to cyclic carbonates at 4 bar with almost 100% yield and selectivity, and in the conversion of CO2 to methanol and methane electrochemically. Additionally, it also catalyzes C-C bond formation via the Knoevenagel reaction.

Formula: C7H6O2. About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Sharma, R; Bansal, A; Ramachandran, CN; Mohanty, P or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Liao, WK; Wang, ZY; Han, YF; Qi, YL; Liu, JA; Xie, J; Tian, Y; Lei, QC; Chen, R; Sun, M; Tang, L; Gong, GW; Zhao, YF in [Liao, Weike; Lei, Qiancheng; Chen, Rui; Tang, Lei] Guizhou Med Univ, Guizhou Prov Engn Technol Res Ctr Chem Drug R&D, State Key Lab Funct & Applicat Med Plants, Guiyang 550004, Peoples R China; [Wang, Zhongyuan; Xie, Juan] Guizhou Prov Peoples Hosp, Dept Pharm, Guiyang 550002, Peoples R China; [Han, Yufei; Qi, Yinliang; Tian, Ye; Sun, Ming; Zhao, Yanfang] Shenyang Pharmaceut Univ, Minist Educ, Key Lab Struct Based Drug Design & Discovery, 103 Wenhua Rd, Shenyang 110016, Peoples R China; [Gong, Guowei] Zunyi Med Univ, Dept Bioengn, Zhuhai Campus, Zhuhai 519041, Guangdong, Peoples R China; [Liu, Jiaan] Univ Massachusetts Amherst, Dept Chem, Amherst, MA 01003 USA published Design, synthesis and biological activity of novel 2,3,4,5-tetra-substituted thiophene derivatives as PI3K alpha inhibitors with potent antitumor activity in 2020.0, Cited 25.0. SDS of cas: 100-83-4. The Name is 3-Hydroxybenzaldehyde. Through research, I have a further understanding and discovery of 100-83-4.

Using a rational design strategy for isoform-selective inhibition of PI3K alpha, two series of novel 2,3,4,5-tetra-substituted thiophene derivatives containing either diaryl urea or N-Acylarylhydrazone scaffold were designed and synthesized. The most promising compound 12k was demonstrated to bear nanomolar PI3K alpha inhibitory potency with 12, 28, 30, 196-fold selectivity against isoforms beta, gamma, delta and mTOR. Besides, it also showed good developability profiles in cell-based proliferation against a panel of human tumor cells as well as ADME assays. We herein report on their design, synthesis, SAR and potential developability properties. (C) 2020 Elsevier Masson SAS. All rights reserved.

SDS of cas: 100-83-4. About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Liao, WK; Wang, ZY; Han, YF; Qi, YL; Liu, JA; Xie, J; Tian, Y; Lei, QC; Chen, R; Sun, M; Tang, L; Gong, GW; Zhao, YF or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

In 2021.0 ENVIRON CHEM LETT published article about ONE-POT SYNTHESIS; POLYHYDROQUINOLINE DERIVATIVES; ORGANIC-SYNTHESIS; CHEMISTRY in [Chen, Lu; Lin, Zhenyuan; Zhang, Xuefang; Tan, Leshi; Zhang, Min; Li, Yibiao] Wuyi Univ, Sch Biotechnol & Hlth Sci, Jiangmen, Peoples R China in 2021.0, Cited 40.0. The Name is 3-Hydroxybenzaldehyde. Through research, I have a further understanding and discovery of 100-83-4. Computed Properties of C7H6O2

The synthesis of nitrogen- and oxygen-containing heterocycles has found many applications in the preparation of biomedical intermediates, yet actual synthetic procedures display limitations such as high-loading catalysts, harsh reaction conditions and tedious preparation of heterogeneous catalysts. Alternatively, photocatalysis allows to access functional products with minimum synthetic procedures and waste generation. Here, we present an efficient, simple, green protocol for the synthesis of N- and O-containing six-membered-ring compounds under mild conditions under visible blue light. Various aldehydes and 1,3-diketones can be reacted to afford eight series of corresponding 1,4-dihydropyridines and 4H-benzo[b]pyrans. This protocol has some merits such as the use of abundant and sustainable aqueous ethanol as solvent, short reaction time (within 60 min), no need of catalyst and broad functional group tolerance to afford 81 different series of target molecules in 75-96% yield under mild conditions.

Bye, fridends, I hope you can learn more about C7H6O2, If you have any questions, you can browse other blog as well. See you lster.. Computed Properties of C7H6O2

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles