Category: 100-83-4

COA of Formula: C7H6O2. In 2019.0 EUR J MED CHEM published article about BIOLOGICAL EVALUATION; EXPRESSION; BCL-2; METASTASIS; APOPTOSIS; ANALOGS; GROWTH; TUMOR; CARBOPLATIN; COMBINATION in [Liu, Gang; Ding, Chunyong; Chen, Haiying; Wold, Eric A.; Ding, Ye; Zhou, Jia] Univ Texas Med Branch, Dept Pharmacol & Toxicol, Chem Biol Program, Galveston, TX 77555 USA; [Yin, Tao; Kim, Hyejin; Yu, Zhuo; Wang, Hong; Yan, Ruping; Zou, Hao; Liu, Xi; Shen, Qiang] Univ Texas MD Anderson Canc Ctr, Dept Clin Canc Prevent, Div Canc Prevent & Populat Sci, Houston, TX 77030 USA in 2019.0, Cited 44.0. The Name is 3-Hydroxybenzaldehyde. Through research, I have a further understanding and discovery of 100-83-4.

In an effort to develop novel Bax activators for breast cancer treatment, a series of diverse analogues have been designed and synthesized based on lead compound SMBA1 through several strategies, including introducing various alkylamino side chains to have a deeper access to S184 pocket, replacing carbon atoms with nitrogen, and reducing the nitro group of 9H-fluorene scaffold. Compounds 14 (CYD-2-11) and 49 (CYD-4-61) have been identified to exhibit significantly improved antiproliferative activity compared to SMBA1, with IC50 values of 3.22 mu M and 0.07 mu M against triple-negative breast cancer MDA-MB-231 and 3.81 mu M and 0.06 mu M against ER-positive breast cancer MCF-7 cell lines, respectively. Mechanism of action studies of compound 49 indicated that it can activate Bax protein to induce cytochrome c release and regulate apoptotic biomarkers, leading to cancer cell apoptosis. Further in vivo efficacy studies of compounds 14 and 49 in nude mice bearing MDA-MB-231 tumor xenografts demonstrated that these drug candidates can significantly suppress tumor growth, indicating their therapeutic potential for the treatment of breast cancer. (C) 2019 Elsevier Masson SAS. All rights reserved.

Welcome to talk about 100-83-4, If you have any questions, you can contact Liu, G; Yin, T; Kim, Y; Ding, CY; Yu, Z; Wang, H; Chen, HY; Yan, RP; Wold, EA; Zou, H; Liu, X; Ding, Y; Shen, Q; Zhou, J or send Email.. COA of Formula: C7H6O2

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recently I am researching about IONIC LIQUID; EFFICIENT; CATALYST, Saw an article supported by the Inha University Research Grant. Published in ELSEVIER in AMSTERDAM ,Authors: Taher, A; Lumbiny, BJ; Lee, IM. The CAS is 100-83-4. Through research, I have a further understanding and discovery of 3-Hydroxybenzaldehyde. Computed Properties of C7H6O2

An amine-functionalized metal organic framework (MOF) was used as highly efficient and recyclable heterogeneous catalyst for Knoevenagel condensation of various aromatic aldehydes and ketones in ethanol. The catalytic efficiency was demonstrated by the high conversion of the reactants with 100% selectivity under microwave (mu W) irradiation, while dramatically reduced the reaction time as compared to the conventional heating method. Importantly, the MOF maintained its structural integrity after catalytic reactions and it could be reused several times without remarkable loss of activity.

Computed Properties of C7H6O2. Welcome to talk about 100-83-4, If you have any questions, you can contact Taher, A; Lumbiny, BJ; Lee, IM or send Email.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Authors Ullah, H; Rahim, F; Taha, M; Hussain, R; Wadood, A; Nawaz, M; Wahab, Z; Kanwal; Khan, KM in BENTHAM SCIENCE PUBL LTD published article about BIOLOGICAL EVALUATION; ANALOGS; ACETYLCHOLINESTERASE; HYDRAZIDE; ETHER in [Ullah, Hayat; Rahim, Fazal; Hussain, Raffaqat; Nawaz, Mohsan] Hazara Univ, Dept Chem, Mansehra 21300, Pakistan; [Taha, Muhammad; Khan, Khalid M.] Imam Abdulrahman Bin Faisal Univ, Inst Res & Med Consultat IRMC, Dept Clin Pharm, POB 31441, Dammam, Saudi Arabia; [Wadood, Abdul] Abdul Wali Khan Univ Mardan, Dept Biochem, Mardan 23200, Pakistan; [Wahab, Zainul] Hazara Univ, Dept Conservat Sci, Mansehra 21300, Pakistan; [Kanwal; Khan, Khalid M.] Univ Karachi, Int Ctr Chem & Biol Sci, HEJ Res Inst Chem, Karachi 75270, Pakistan in 2020.0, Cited 37.0. Product Details of 100-83-4. The Name is 3-Hydroxybenzaldehyde. Through research, I have a further understanding and discovery of 100-83-4

Background: In the recent past, we have synthesized and repotted different derivatives of oxadiazoles as potential alpha-glucosidase inhibitors, keeping in mind, the pharmacological aspects of oxadiazole moiety and in continuation of our ongoing research on the chemistry and bioactivity of new heterocyclic compounds. Methods: 1,3,4-Oxadiazole derivatives (1-14) have been synthesized and characterized by different spectroscopic techniques such as H-1,-C-1(3)-NMR and HREI-MS. Results: The synthetic derivatives were screened for alpha-glucosidase inhibitory potential. All compounds exhibited good inhibitory activity with IC50 values ranging between 0.80 +/- 0.1 to 45.1 +/- 1.7 mu M in comparison with the standard acarbose having IC50 value 38.45 + 0.80 mu M. Conclusion: Thirteen compounds 1-6 and 8-14 showed potential inhibitory activity as compared to the standard acarbose having IC50 value 38.45 1 0.80 mu M, however, only one compound 7 (IC50 = 45.1 +/- 1.7 mu M) was found to be less active. Compound 14 (IC50 – 0.80 +/- 0.1 mu M) showed promising inhibitory activity among all synthetic derivatives. Molecular docking studies were also conducted for the active compounds to understand the ligand-enzyme binding interactions.

Product Details of 100-83-4. Welcome to talk about 100-83-4, If you have any questions, you can contact Ullah, H; Rahim, F; Taha, M; Hussain, R; Wadood, A; Nawaz, M; Wahab, Z; Kanwal; Khan, KM or send Email.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

In 2019.0 BIOORG CHEM published article about COLCHICINE BINDING-SITE; BIOLOGICAL EVALUATION; COMBRETASTATIN A-4; TUBULIN; INHIBITORS; CHEMOTHERAPY; DERIVATIVES; DESIGN; SERIES in [Zhang, Ya-Liang; Yang, Rong; Xia, Lin-Ying; Man, Ruo-Jun; Chu, Yi-Chun; Wang, Zhong-Chang; Zhu, Hai-Liang] Nanjing Univ, Sch Life Sci, State Key Lab Pharmaceut Biotechnol, Nanjing 210023, Jiangsu, Peoples R China; [Man, Ruo-Jun] Guangxi Univ Nationalities, Guangxi Biol Polysaccharide Separat Purificat & M, Nanning 530006, Peoples R China; [Jiang, Ai-Qin] Nanjing Univ, Med Sch, Nanjing 210093, Jiangsu, Peoples R China in 2019.0, Cited 29.0. The Name is 3-Hydroxybenzaldehyde. Through research, I have a further understanding and discovery of 100-83-4. Recommanded Product: 3-Hydroxybenzaldehyde

Twenty-four 1,2-diarylbenzimidazole derivatives were designed, synthesized and biologically evaluated. It turned out that most of them were potential anticancer drugs. Among them, compound c24 showed the highest anti-tumor activity (GI(50) = 0.71-2.41 mu M against HeLa, HepG2, A549 and MCF-7 cells), and low toxicity to normal cells (CC50 > 100 mu M against L02 cells). In the microtubule binding assay, c24 showed the most potent inhibition of microtubule polymerization (IC50 = 8.47 mu M). The binding ability of compound c24 to tubulin crystal was verified by molecular docking simulation experiment. Further studies on HepG2 and HeLa cells showed that compound c24 could cause mitotic arrest of tumor cells to G2/M phase then inducing apoptosis. To sum up, compound c24 is a promising microtubule assembly inhibitor.

Recommanded Product: 3-Hydroxybenzaldehyde. Bye, fridends, I hope you can learn more about C7H6O2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

I found the field of Pharmacology & Pharmacy; Chemistry very interesting. Saw the article New vinyl-1,2,4-triazole derivatives as antimicrobial agents: Synthesis, biological evaluation and molecular docking studies published in 2020.0. Quality Control of 3-Hydroxybenzaldehyde, Reprint Addresses Stingaci, E (corresponding author), Inst Chem, Lab Organ Synth & Biopharmaceut, 3 Str Acad, Kishinev, Moldova.. The CAS is 100-83-4. Through research, I have a further understanding and discovery of 3-Hydroxybenzaldehyde

1,2,4-Triazole is a very important scaffold in medicinal chemistry due to the wide spectrum of biological activities and mainly antifungal activity of 1,2,4-triazole derivatives. The main mechanism of antifungal action of the latter is inhibition of 14-alpha-demethylase enzyme (CYP51). The current study presents synthesis and evaluation of eight triazole derivatives for their antimicrobial activity. Docking studies to elucidate the mechanism of action were also performed. The designed compounds were synthesized using classical methods of organic synthesis. The in vivo evaluation of antimicrobial activity was performed by microdilution method. All tested compounds showed good antibacterial activity with MIC and MBC values ranging from 0.0002 to 0.0069 mM. Compound 2 h appeared to be the most active among all tested with MIC at 0.0002-0.0033 mM and MBC at 0.0004-0.0033 mM followed by compounds 2f and 2g. The most sensitive bacterium appeared to be Xanthomonas campestris while Erwinia amylovora was the most resistant. The evaluation of antifungal activity revealed that all compounds showed good antifungal activity with MIC values ranging from 0.02 mM to 0.52 mM and MFC from 0.03 mM to 0.52 mM better than reference drugs ketoconazole (MIC and MFC values at 0.28-1.88 mM and 0.38 mM to 2.82 mM respectively) and bifonazole (MIC and MFC values at 0.32-0.64 mM and 0.64-0.81 mM). The best antifungal activity is displayed by compound 2 h with MIC at 0.02-0.04 mM and MFC at 0.03-0.06 mM while compound 2a showed the lowest activity. The results showed that these compounds could be lead compounds in search for new potent antimicrobial agents. Docking studies confirmed experimental results.

Quality Control of 3-Hydroxybenzaldehyde. Bye, fridends, I hope you can learn more about C7H6O2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Authors Areias, F; Correia, C; Rocha, A; Brea, J; Castro, M; Loza, MI; Proenca, MF; Carvalho, MA in PERGAMON-ELSEVIER SCIENCE LTD published article about MEDICINAL CHEMISTRY; LIGANDS in [Areias, Filipe; Correia, Carla; Rocha, Ashly; Fernanda Proenca, M.; Alice Carvalho, M.] Univ Minho, Ctr Chem, Campus Gualtar, P-4710057 Braga, Portugal; [Areias, Filipe; Brea, Jose; Castro, Marian; Loza, Maria, I] Univ Santiago de Compostela, Dept Pharmacol, Edificio CIMUS,Avda Barcelona, Santiago De Compostela 15782, Spain; [Areias, Filipe] Yachay Tech Univ, Sch Chem Sci & Engn, Yachay City Of Knowledge 100119, Urcuqui, Ecuador in 2019.0, Cited 19.0. Recommanded Product: 3-Hydroxybenzaldehyde. The Name is 3-Hydroxybenzaldehyde. Through research, I have a further understanding and discovery of 100-83-4

From a collection containing more than 1500 academic compounds, in silico screening identified a hit for the human A(1) adenosine receptor containing a new purine scaffold. To study the structure activity relationships of this new chemical series for adenosine receptors, a library of 24 purines was synthesized and tested in radioligand binding assays at human A(1), A(2A), A(2B) and A(3) adenosine receptor subtypes. Fourteen molecules showed potent antagonism at A(1), A(3) or dual A(1)/A(3) adenosine receptors. This purine scaffold is an important source for novel biochemical tools and/or therapeutic drugs.

About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Areias, F; Correia, C; Rocha, A; Brea, J; Castro, M; Loza, MI; Proenca, MF; Carvalho, MA or concate me.. Recommanded Product: 3-Hydroxybenzaldehyde

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Inhibition of nitric oxide and prostaglandin E-2 production by pyrrolylated-chalcones: Synthesis, biological activity, crystal structure analysis, and molecular docking studies WOS:000505596300032 published article about CURCUMIN ANALOGS; KAPPA-B; DERIVATIVES; INFLAMMATION; FLAVONOIDS; SYNTHASE in [Faudzi, Siti Munirah Mohd; Abdullah, Maryam Aisyah; Manap, Mohd Rashidi Abdull; Ismail, Ahmad Zaidi] Univ Putra Malaysia, Fac Sci, Dept Chem, Serdang 43400, Selangor, Malaysia; [Faudzi, Siti Munirah Mohd; Abas, Faridah; Lajis, Nordin H.] Univ Putra Malaysia, Inst Biosci, Lab Nat Prod, Serdang 43400, Selangor, Malaysia; [Rullah, Kamal] Int Islamic Univ Malaysia, Kuliyyah Pharm, Dept Pharmaceut Chem, Kuantan 25200, Pahang, Malaysia; [Aluwi, Mohd Fadhlizil Fasihi Mohd; Ramli, Aizi Nor Mazila] Univ Malaysia Pahang, Fac Ind Sci & Technol, Kuantan 26300, Pahang, Malaysia; [Abas, Faridah] Univ Putra Malaysia, Fac Food Sci & Technol, Dept Food Sci, Serdang 43400, Selangor, Malaysia in 2020.0, Cited 40.0. COA of Formula: C7H6O2. The Name is 3-Hydroxybenzaldehyde. Through research, I have a further understanding and discovery of 100-83-4

In search of potent anti-inflammatory agents, twenty-four chalcone derivatives including seven new compounds (13 – 17, 21 and 23) containing pyrrole moiety were designed, synthesized, and assessed for their nitric oxide (NO) and prostaglandin E-2 (PGE(2)) suppression ability on IFN-gamma/LPS-induced RAW 264.7 macrophage cells. Results showed that none of the synthesized compounds were PAINS-associated molecules, with 3-(2,5-dimethoxyphenyl)-1-(1H-pyrrol-2-yl) prop-2-en-1-one (compound 16) exhibiting remarkable inhibition activity towards PGE(2) and NO production with IC50 values of 0.5 +/- 1.5 mu M and 12.1 +/- 1.5 mu M, respectively. Physicochemical and ADMET studies showed that majority of the compounds obey to Lipinski’s rule of five (RO5) having high blood brain barrier (BBB) penetration, human intestinal absorption (HIA), P- glycoprotein (PgP) inhibition and plasma binding protein (PPB) inhibition. The obtained atomic coordinates for the single-crystal XRD of 16 were then applied in a molecular docking simulation, and compound 16 was found to participate in a number of important binding interactions in the binding sites of ERK and mPGES-1. Based on these results, we have observed the potential of compound 16 as a new hit anti-inflammatory agent, and these findings could serve as a basis for further studies on its mechanism of action.

COA of Formula: C7H6O2. Bye, fridends, I hope you can learn more about C7H6O2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Green synthesis of aminocarbonyl compounds using a nanostructured heterogeneous catalyst under mild reaction conditions WOS:000485111500002 published article about POT MULTICOMPONENT SYNTHESIS; 3-COMPONENT SYNTHESIS; NANOCATALYST; NANOPARTICLES; EFFICIENT in [Maleki, Ali; Firouzi-Haji, Razieh] Iran Univ Sci & Technol, Catalysts & Organ Synth Res Lab, Dept Chem, Tehran 1684613114, Iran in 2019.0, Cited 14.0. Safety of 3-Hydroxybenzaldehyde. The Name is 3-Hydroxybenzaldehyde. Through research, I have a further understanding and discovery of 100-83-4

The synthesis of aminocarbonyl derivatives as biologically active compounds by using polyethylene glycol (PEG-400)-SO3H-coated Fe2O3 is reported. The heterogeneous nanocatalyst was prepared via in-situ co-precipitation method and its structure and morphology was characterized by Fourier-transform infrared spectroscopy, energy-dispersive X-ray analysis, X-ray diffraction pattern, field-emission scanning electron microscopy image, vibrating sample magnetometer curves, N-2 adsorption-desorption isotherm and inductively-coupled plasma analysis. Noteworthy, the green composite nanocatalyst was applied for the one-pot multicomponent synthesis of aminocarbonyl compounds at room temperature. This work had advantages such as significant nanocatalyst activity, recoverability, short process time, mild reaction conditions and high products yields.

Safety of 3-Hydroxybenzaldehyde. Bye, fridends, I hope you can learn more about C7H6O2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Global retention models and their application to the prediction of chromatographic fingerprints WOS:000616104700028 published article about GRADIENT; OPTIMIZATION; ELUTION in [Gisbert-Alonso, A.; Navarro-Huerta, J. A.; Torres-Lapasio, J. R.; Garcia-Alvarez-Coque, M. C.] Univ Valencia, Dept Analyt Chem, Fac Chem, C Dr Moliner 50, Burjassot 46100, Spain in 2021, Cited 43. The Name is 3-Hydroxybenzaldehyde. Through research, I have a further understanding and discovery of 100-83-4. Recommanded Product: 100-83-4

The resolution of samples containing unknown compounds of different nature, or without standards available, as is the case of chromatographic fingerprints, is still a challenge. Possibly, the most problematic aspect that prevents systematic method development is finding models that describe without bias the retention behaviour of the compounds in the samples. In this work, the use of global models (able to describe the whole sample) is proposed as an alternative to the use of individual models for each solute. Global models contain parameters that are specific for each solute, while other parameters -related to the column and solvent- are common for all solutes. A special regression procedure is presented for the construction of global models, which are applied to predict highly complex chromatograms, such as chromatographic fingerprints, for diverse experimental conditions in isocratic and gradient elution. Another interesting application is the prediction of molecular properties, such as log P-o/w from the specific solute parameters of the global models. The examined adapted models are based on the equations proposed by Snyder, Schoenmakers, Neue and Kuss, Jandera, and Bosch Roses to describe the retention. In all cases, the predictive capability was very satisfactory. Two cases of study were considered: chromatograms of camomile extracts analysed using acetonitrile gradients, and a set of 145 known compounds in a wide range of structures and functionalities, eluted isocratically with acetonitrile/water mobile phases. (C) 2020 Elsevier B.V. All rights reserved.

Welcome to talk about 100-83-4, If you have any questions, you can contact Gisbert-Alonso, A; Navarro-Huerta, JA; Torres-Lapasio, JR; Garcia-Alvarez-Coque, MC or send Email.. Recommanded Product: 100-83-4

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

In 2020.0 CHEMISTRYSELECT published article about HECK REACTION; AZOMETHINE YLIDES; AMINO-ACIDS; DERIVATIVES; SPIROPYRROLIZIDINES; HETEROCYCLES; CHEMISTRY; PALLADIUM; PROTOCOL; KETONES in [Teja, Chitrala; Khan, Fazlur Rahman Nawaz] Vellore Inst Technol, Sch Adv Sci, Organ & Med Chem Res Lab, Vellore 632014, Tamil Nadu, India in 2020.0, Cited 37.0. The Name is 3-Hydroxybenzaldehyde. Through research, I have a further understanding and discovery of 100-83-4. Safety of 3-Hydroxybenzaldehyde

Tetrabutylammonium-bromide promoted, ytterbium triflate catalyzed one-pot domino synthesis of spirooxindoles is described. The hydration-condensation of alkyne,1aldehyde,2C-C coupling followed by 1,3-dipolar cycloaddition of in-situ generated azomethine ylide from Isatin,3and L-proline,4 aor sarcosine,4 bfurnished novel spirooxindoles,5under solvent-free green-chemical conditions, in high regio and stereo selectivities and yields. The regio and stereochemistry of the synthesized derivatives were characterized by 2D NMR Spectroscopic studies.

About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Teja, C; Khan, FRN or concate me.. Safety of 3-Hydroxybenzaldehyde

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles