Category: 100-83-4

I found the field of Chemistry very interesting. Saw the article Novel camphor-based pyrimidine derivatives induced cancer cell death through a ROS-mediated mitochondrial apoptosis pathway published in 2019.0. HPLC of Formula: C7H6O2, Reprint Addresses Wang, SF (corresponding author), Nanjing Forestry Univ, Coll Chem Engn, Nanjing 210037, Jiangsu, Peoples R China.; Zhu, YQ (corresponding author), Jiangsu Chia Tai Fenghai Pharmaceut Co Ltd, Nanjing 210046, Jiangsu, Peoples R China.; Wang, SF (corresponding author), Nanjing Forestry Univ, Coinnovat Ctr Efficient Proc & Utilizat Forest Re, Nanjing 210037, Jiangsu, Peoples R China.. The CAS is 100-83-4. Through research, I have a further understanding and discovery of 3-Hydroxybenzaldehyde

A series of novel camphor-based pyrimidine derivatives (3a-3x) have been synthesized; their structures were determined by using conventional methods and compound 3f was further confirmed through single crystal XRD analysis. The cytotoxic activity of the target compounds against a panel of human normal (GES-1) and cancer cell lines (MDA-MB-231, RPMI-8226, A549) was evaluated by MTS assay. Here we found that compound 3f exhibited the strongest anti-tumor activity, comparable to that of etoposide, and had much lower cytotoxicity to normal GES-1 cells (IC50 > 50 mu M) than the reference drug (IC50 = 8.89 mu M). Subsequent mechanism studies in MDA-MB-231 cells revealed that compound 3f caused G0/G1 phase arrest and apoptosis in a dose dependent manner. Moreover, the loss of mitochondrial membrane potential and enhancement of cellular ROS levels were also observed upon 3f treatment, which indicated that 3f exerted cytotoxic activity by a ROS-mediated mitochondrial apoptosis pathway. This result was confirmed by a significant increase in the expression of pro-apoptotic proteins Bax, cytochrome C and caspase-3, and downregulation of anti-apoptosis protein Bcl-2. Overall, 3f can be adopted for further investigation in the development of antitumor agents based on natural products.

HPLC of Formula: C7H6O2. About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Zhang, Y; Wang, YY; Zhao, YX; Gu, W; Zhu, YQ; Wang, SF or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Authors Aksoy, BT; Kesan, G; Ozcan, E; Ecik, ET; Dere, A; Karabulut, A; Yakuphanoglu, F; Cosut, B in ROYAL SOC CHEMISTRY published article about ORGANIC SEMICONDUCTOR; HIGH-PERFORMANCE; FLUORESCENCE; DERIVATIVES; 1,3,5-TRIAZINE; SILICON; PHOTODETECTOR; COMPLEX; DONOR; FILMS in [Aksoy, Burcu Topaloglu; Ozcan, Emrah; Cosut, Bunyemin] Gebze Tech Univ, Dept Chem, Kocaeli, Turkey; [Kesan, Gurkan; Ozcan, Emrah] Univ South Bohemia, Inst Phys, Fac Sci, Branisovska 1760, Ceske Budejovice 37005, Czech Republic; [Ecik, Esra Tannverdi] Ataturk Univ, Dept Chem, Erzurum, Turkey; [Dere, Aysegul; Yakuphanoglu, Fahrettin] Firat Univ, Nanosci & Nanotechnol Lab, Elazig, Turkey; [Yakuphanoglu, Fahrettin] Firat Univ, Fac Sci, Dept Phys, Elazig, Turkey; [Karabulut, Abdulkerim] Sinop Univ, Fac Engn, Dept Elect & Elect Engn, Sinop, Turkey in 2020.0, Cited 45.0. Computed Properties of C7H6O2. The Name is 3-Hydroxybenzaldehyde. Through research, I have a further understanding and discovery of 100-83-4

Solution-processed organic photodiodes can function as thin-film candidates for solid-state photosensors in various optoelectronic applications due to the physical and chemical tuneability. In spite of their exclusive optical, structural, and electronic properties, the development of BODIPY based organic phodiodes has lagged behind that of other luminescent chromophore units. Here, we demonstrate the design, synthesis, and characterization of new BODIPY decorated triazine tripods for next-generation solution-processed photosensor applications. The photophysical and thermal properties of the BODIPY decorated triazines were determined. Furthermore, the photo-electrochemical properties of the synthesized compounds have been studied in detail using a photoconductivity measurement system. The potential of the prepared diodes as sensors in solar tracking systems has been investigated. Also, quantum chemical calculations were applied to those compounds to examine the effect of both OH groups and different binding positions on those compounds in comparison with experimentally observed data. As a potential application area, the photodiode properties of the designed molecules were tested here. The obtained photoelectrical results indicate that BODIPY decorated triazine tripod based photodiodes can be used as a photosensor in optic control systems.

About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Aksoy, BT; Kesan, G; Ozcan, E; Ecik, ET; Dere, A; Karabulut, A; Yakuphanoglu, F; Cosut, B or concate me.. Computed Properties of C7H6O2

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Formula: C7H6O2. In 2019.0 BIOORG MED CHEM LETT published article about HEMORRHAGIC-FEVER VIRUSES; LASSA FEVER; IDENTIFICATION; RIBAVIRIN in [Plewe, Michael B.; Naik, Shibani; Brown, Eric R.; Sokolova, Nadezda, V; Gantla, Vidyasagar Reddy; Henkel, Greg; McCormack, Ken] Arisan Therapeut, 11189 Sorrento Valley Rd,Suite 104, San Diego, CA 92054 USA; [Whitby, Landon R.; Boger, Dale L.] Scripps Res Inst, Dept Chem, 10550 North Torrey Pines Rd, La Jolla, CA 92037 USA; [Boger, Dale L.] Scripps Res Inst, Skaggs Inst Chem Biol, 10550 North Torrey Pines Rd, La Jolla, CA 92037 USA; [York, Joanne; Nunberg, Jack H.] Univ Montana, Montana Biotechnol Ctr, Missoula, MT 59812 USA; [Zhang, Lihong; Kalveram, Birte; Freiberg, Alexander N.] Univ Texas Med Branch, Dept Pathol, Galveston, TX 77555 USA; [Freiberg, Alexander N.] Univ Texas Med Branch, Ctr Biodef & Emerging Infect Dis, Galveston, TX 77555 USA in 2019.0, Cited 32.0. The Name is 3-Hydroxybenzaldehyde. Through research, I have a further understanding and discovery of 100-83-4.

Old World (Africa) and New World (South America) arenaviruses are associated with human hemorrhagic fevers. Efforts to develop small molecule therapeutics have yielded several chemical series including the 4-acyl-1,6-dialkylpiperazin-2-ones. Herein, we describe an extensive exploration of this chemotype. In initial Phase I studies, R-1 and R-4 scanning libraries were assayed to identify potent substituents against Old World (Lassa) virus. In subsequent Phase II studies, R-6 substituents and iterative R-1, R-4 and R-6 substituent combinations were evaluated to obtain compounds with improved Lassa and New World (Machupo, Junin, and Tacaribe) arenavirus inhibitory activity, in vitro human liver microsome metabolic stability and aqueous solubility.

Bye, fridends, I hope you can learn more about C7H6O2, If you have any questions, you can browse other blog as well. See you lster.. Formula: C7H6O2

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recently I am researching about END-PRODUCTS; NONENZYMATIC GLYCATION; MAILLARD REACTION; ACCURATE DOCKING; LENS PROTEINS; INHIBITORS; DERIVATIVES; GLIDE; FRUCTOSYLATION; AMINOGUANIDINE, Saw an article supported by the Higher Education Commission (HEC), Pakistan under National Research Program for Universities [20-1910, 20-1356/RD/09/5413]. Product Details of 100-83-4. Published in BENTHAM SCIENCE PUBL LTD in SHARJAH ,Authors: Shaikh, M; Siddiqui, S; Zafar, H; Naqeeb, U; Subzwari, F; Imad, R; Khan, KM; Choudhary, MI. The CAS is 100-83-4. Through research, I have a further understanding and discovery of 3-Hydroxybenzaldehyde

Background: Advanced glycation end products (AGEs) are known to be involved in the pathophysiology of diabetic complications, neurodegenerative diseases, and aging. Preventing the formation of AGEs can be helpful in the management of these diseases. Objectives: Two classes of previously synthesized traizole Schiff’s bases (4H-1,2,4-triamle-4-Schiff’s bases 1-14, and 4H-1,2,4-triazole-3-Schiff’s bases 15-23) were evaluated for their in vitro antiglycation activity. Methods: In vitro fructose-mediated human serum albumin (HSA) glycation assay was employed to assess the antiglycation activity of triazole Schiff’s bases. The active compounds were subjected to cytotoxicity analysis by MTT assay on mouse fibroblast (3T3) cell line. Molecular docking and simulation studies were carried out to evaluate the interactions and stability of compounds with HSA. Anti-hyperglycemic and antioxidant activities of selected non-cytotoxic compounds were evaluated by in vitro a-glucosidase inhibition, and DPPH free radical scavenging assays, respectively. Results: Compound 1 (IC50 =47.30 +/- 0.38 mu M) from 4H-1,2,4-triazole-4-Schiff’s bases has exhibited antiglycation activity comparable to standard rutin (IC50 =54.5 +/- 0.05 mu M) along with a stable RMSD profile in MD simulation studies. Compound 1 also exhibited a potent a-glucosidase inhibitory activity, and moderate antioxidant property. Other derivatives showed a weak antiglycation activity with IC50 values between 248.1-637.7 mu M. Compounds with potential antiglycation profile were found to be non-cytotoxic in a cellular assay. Conclusion: The study identifies triazole Schiff s bases active against fructose-mediated glycation of HSA, thus indicates their potential against late diabetic complications due to production of advancedend products (AGEs).

Product Details of 100-83-4. About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Shaikh, M; Siddiqui, S; Zafar, H; Naqeeb, U; Subzwari, F; Imad, R; Khan, KM; Choudhary, MI or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Ullah, H; Rahim, F; Taha, M; Hussain, R; Wadood, A; Nawaz, M; Wahab, Z; Kanwal; Khan, KM in [Ullah, Hayat; Rahim, Fazal; Hussain, Raffaqat; Nawaz, Mohsan] Hazara Univ, Dept Chem, Mansehra 21300, Pakistan; [Taha, Muhammad; Khan, Khalid M.] Imam Abdulrahman Bin Faisal Univ, Inst Res & Med Consultat IRMC, Dept Clin Pharm, POB 31441, Dammam, Saudi Arabia; [Wadood, Abdul] Abdul Wali Khan Univ Mardan, Dept Biochem, Mardan 23200, Pakistan; [Wahab, Zainul] Hazara Univ, Dept Conservat Sci, Mansehra 21300, Pakistan; [Kanwal; Khan, Khalid M.] Univ Karachi, Int Ctr Chem & Biol Sci, HEJ Res Inst Chem, Karachi 75270, Pakistan published Synthesis, In vitro alpha-Glucosidase Inhibitory Potential and Molecular Docking Studies of 2-Amino-1,3,4-Oxadiazole Derivatives in 2020.0, Cited 37.0. COA of Formula: C7H6O2. The Name is 3-Hydroxybenzaldehyde. Through research, I have a further understanding and discovery of 100-83-4.

Background: In the recent past, we have synthesized and repotted different derivatives of oxadiazoles as potential alpha-glucosidase inhibitors, keeping in mind, the pharmacological aspects of oxadiazole moiety and in continuation of our ongoing research on the chemistry and bioactivity of new heterocyclic compounds. Methods: 1,3,4-Oxadiazole derivatives (1-14) have been synthesized and characterized by different spectroscopic techniques such as H-1,-C-1(3)-NMR and HREI-MS. Results: The synthetic derivatives were screened for alpha-glucosidase inhibitory potential. All compounds exhibited good inhibitory activity with IC50 values ranging between 0.80 +/- 0.1 to 45.1 +/- 1.7 mu M in comparison with the standard acarbose having IC50 value 38.45 + 0.80 mu M. Conclusion: Thirteen compounds 1-6 and 8-14 showed potential inhibitory activity as compared to the standard acarbose having IC50 value 38.45 1 0.80 mu M, however, only one compound 7 (IC50 = 45.1 +/- 1.7 mu M) was found to be less active. Compound 14 (IC50 – 0.80 +/- 0.1 mu M) showed promising inhibitory activity among all synthetic derivatives. Molecular docking studies were also conducted for the active compounds to understand the ligand-enzyme binding interactions.

COA of Formula: C7H6O2. Welcome to talk about 100-83-4, If you have any questions, you can contact Ullah, H; Rahim, F; Taha, M; Hussain, R; Wadood, A; Nawaz, M; Wahab, Z; Kanwal; Khan, KM or send Email.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Authors Plewe, MB; Whitby, LR; Naik, S; Brown, ER; Sokolova, NV; Gantla, VR; York, J; Nunberg, JH; Zhang, LH; Kalveram, B; Freiberg, AN; Boger, DL; Henkel, G; McCormack, K in PERGAMON-ELSEVIER SCIENCE LTD published article about HEMORRHAGIC-FEVER VIRUSES; LASSA FEVER; IDENTIFICATION; RIBAVIRIN in [Plewe, Michael B.; Naik, Shibani; Brown, Eric R.; Sokolova, Nadezda, V; Gantla, Vidyasagar Reddy; Henkel, Greg; McCormack, Ken] Arisan Therapeut, 11189 Sorrento Valley Rd,Suite 104, San Diego, CA 92054 USA; [Whitby, Landon R.; Boger, Dale L.] Scripps Res Inst, Dept Chem, 10550 North Torrey Pines Rd, La Jolla, CA 92037 USA; [Boger, Dale L.] Scripps Res Inst, Skaggs Inst Chem Biol, 10550 North Torrey Pines Rd, La Jolla, CA 92037 USA; [York, Joanne; Nunberg, Jack H.] Univ Montana, Montana Biotechnol Ctr, Missoula, MT 59812 USA; [Zhang, Lihong; Kalveram, Birte; Freiberg, Alexander N.] Univ Texas Med Branch, Dept Pathol, Galveston, TX 77555 USA; [Freiberg, Alexander N.] Univ Texas Med Branch, Ctr Biodef & Emerging Infect Dis, Galveston, TX 77555 USA in 2019.0, Cited 32.0. SDS of cas: 100-83-4. The Name is 3-Hydroxybenzaldehyde. Through research, I have a further understanding and discovery of 100-83-4

Old World (Africa) and New World (South America) arenaviruses are associated with human hemorrhagic fevers. Efforts to develop small molecule therapeutics have yielded several chemical series including the 4-acyl-1,6-dialkylpiperazin-2-ones. Herein, we describe an extensive exploration of this chemotype. In initial Phase I studies, R-1 and R-4 scanning libraries were assayed to identify potent substituents against Old World (Lassa) virus. In subsequent Phase II studies, R-6 substituents and iterative R-1, R-4 and R-6 substituent combinations were evaluated to obtain compounds with improved Lassa and New World (Machupo, Junin, and Tacaribe) arenavirus inhibitory activity, in vitro human liver microsome metabolic stability and aqueous solubility.

Bye, fridends, I hope you can learn more about C7H6O2, If you have any questions, you can browse other blog as well. See you lster.. SDS of cas: 100-83-4

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Safety of 3-Hydroxybenzaldehyde. In 2020.0 ORG PROCESS RES DEV published article about EXPERIMENTATION; CHEMISTRY in [Logsdon, David L.; Li, Yangjie; Thompson, David H.; Cooks, R. Graham] Purdue Univ, Dept Chem, W Lafayette, IN 47907 USA; [Sobreira, Tiago Jose Paschoal; Ferreira, Christina R.; Thompson, David H.; Cooks, R. Graham] Purdue Univ, Bindley Biosci Ctr, W Lafayette, IN 47907 USA in 2020.0, Cited 18.0. The Name is 3-Hydroxybenzaldehyde. Through research, I have a further understanding and discovery of 100-83-4.

This study describes the latest generation of a high-throughput screening system that is capable of screening thousands of organic reactions in a single day. This system combines a liquid handling robot with desorption electrospray ionization (DESI) mass spectrometry (MS) for a rapid reaction mixture preparation, accelerated synthesis, and automated MS analysis. A total of 3840 unique reductive amination reactions were screened to demonstrate the throughputs that are capable with the system. Products, byproducts, and intermediates were all monitored in full-scan mass spectra, generating a complete view of the reaction progress. Tandem mass spectrometry experiments were conducted to verify the identity of the products formed. The amine and electrophile reactivity trends represented in the data match what is expected from theory, indicating that the system accurately models the reaction performance. The DESI results correlated well with those generated using more traditional mass spectrometry techniques like liquid chromatography-mass spectrometry, validating the data generated by the system.

Safety of 3-Hydroxybenzaldehyde. About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Logsdon, DL; Li, YJ; Sobreira, TJP; Ferreira, CR; Thompson, DH; Cooks, RG or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Authors O’Brien, NS; McCluskey, A in CSIRO PUBLISHING published article about ONE-POT SYNTHESIS; SOLVENT PROMOTED ADDITION; EFFICIENT SYNTHESIS; QUINAZOLIN-4(3H)-ONES; DERIVATIVES; CONVENIENT; OXIDE in [O’Brien, Nicholas S.; McCluskey, Adam] Univ Newcastle, Sch Environm & Life Sci, Chem, Univ Dr, Callaghan, NSW 2308, Australia in 2020.0, Cited 35.0. Product Details of 100-83-4. The Name is 3-Hydroxybenzaldehyde. Through research, I have a further understanding and discovery of 100-83-4

An elegantly simple, facile, and robust approach to a scaffold of biological importance, 2,3-dihydroquinazolin-4(1H)-ones, is reported. A catalytic 1% SnCl2/microwave-mediated approach afforded access to pure material, collected by cooling and filtration after 20-min microwave irradiation at 120 degrees C. Atotal of 41 analogues were prepared in isolated yields of 17-99 %. This process was highly tolerant of aliphatic, aromatic, heterocyclic, and acyclic aldehydes, but furan, pyrrole, and thiophene aldehyde reactivity correlated with propensity towards electrophilic addition and/or Diels-Alder addition. As a result, thiophene afforded high yields (80 %) whereas pyrrole carboxaldehyde failed to react. With simple cinnamaldehydes, and in the SbCl3-mediated reaction, and with alpha,beta-unsaturated aldehydes the equivalent quinazolin-4(3H)-ones, and not the 2,3-dihydroquinazolin-4(1H)-ones, was favoured.

Welcome to talk about 100-83-4, If you have any questions, you can contact O’Brien, NS; McCluskey, A or send Email.. Product Details of 100-83-4

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recently I am researching about BENZYL ALCOHOLS; ALDEHYDES; NANOPARTICLES; AMINES; GO; REARRANGEMENT; ESTERS, Saw an article supported by the DST-SERB; UGC New DelhiUniversity Grants Commission, India; CSIRCouncil of Scientific & Industrial Research (CSIR) – India. Published in SPRINGER in NEW YORK ,Authors: Dandia, A; Parihar, S; Saini, P; Rathore, KS; Parewa, V. The CAS is 100-83-4. Through research, I have a further understanding and discovery of 3-Hydroxybenzaldehyde. Application In Synthesis of 3-Hydroxybenzaldehyde

We describe an efficient, clean and metal-free procedure for the synthesis of amides via oxidative amidation of aldehydes with anilines using graphene oxide (GO) as a recyclable catalyst and KBrO3 as a mild oxidant in aqueous medium under microwave irradiation. GO nanosheets were prepared and characterized by XRD, TEM, SEM, and FT-IR, analyses. GO showed high compatibility with KBrO3 in water and offered high TOF value (1.30 x 10(-3) mol g(-1) min(-1)). GO oxygen functionalities catalyze the oxidative amidation effectively in mild condition with high recyclability. A plausible mechanism was proposed by the isolating the intermediate.

Application In Synthesis of 3-Hydroxybenzaldehyde. About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Dandia, A; Parihar, S; Saini, P; Rathore, KS; Parewa, V or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Inhibition of nitric oxide and prostaglandin E-2 production by pyrrolylated-chalcones: Synthesis, biological activity, crystal structure analysis, and molecular docking studies WOS:000505596300032 published article about CURCUMIN ANALOGS; KAPPA-B; DERIVATIVES; INFLAMMATION; FLAVONOIDS; SYNTHASE in [Faudzi, Siti Munirah Mohd; Abdullah, Maryam Aisyah; Manap, Mohd Rashidi Abdull; Ismail, Ahmad Zaidi] Univ Putra Malaysia, Fac Sci, Dept Chem, Serdang 43400, Selangor, Malaysia; [Faudzi, Siti Munirah Mohd; Abas, Faridah; Lajis, Nordin H.] Univ Putra Malaysia, Inst Biosci, Lab Nat Prod, Serdang 43400, Selangor, Malaysia; [Rullah, Kamal] Int Islamic Univ Malaysia, Kuliyyah Pharm, Dept Pharmaceut Chem, Kuantan 25200, Pahang, Malaysia; [Aluwi, Mohd Fadhlizil Fasihi Mohd; Ramli, Aizi Nor Mazila] Univ Malaysia Pahang, Fac Ind Sci & Technol, Kuantan 26300, Pahang, Malaysia; [Abas, Faridah] Univ Putra Malaysia, Fac Food Sci & Technol, Dept Food Sci, Serdang 43400, Selangor, Malaysia in 2020.0, Cited 40.0. The Name is 3-Hydroxybenzaldehyde. Through research, I have a further understanding and discovery of 100-83-4. Application In Synthesis of 3-Hydroxybenzaldehyde

In search of potent anti-inflammatory agents, twenty-four chalcone derivatives including seven new compounds (13 – 17, 21 and 23) containing pyrrole moiety were designed, synthesized, and assessed for their nitric oxide (NO) and prostaglandin E-2 (PGE(2)) suppression ability on IFN-gamma/LPS-induced RAW 264.7 macrophage cells. Results showed that none of the synthesized compounds were PAINS-associated molecules, with 3-(2,5-dimethoxyphenyl)-1-(1H-pyrrol-2-yl) prop-2-en-1-one (compound 16) exhibiting remarkable inhibition activity towards PGE(2) and NO production with IC50 values of 0.5 +/- 1.5 mu M and 12.1 +/- 1.5 mu M, respectively. Physicochemical and ADMET studies showed that majority of the compounds obey to Lipinski’s rule of five (RO5) having high blood brain barrier (BBB) penetration, human intestinal absorption (HIA), P- glycoprotein (PgP) inhibition and plasma binding protein (PPB) inhibition. The obtained atomic coordinates for the single-crystal XRD of 16 were then applied in a molecular docking simulation, and compound 16 was found to participate in a number of important binding interactions in the binding sites of ERK and mPGES-1. Based on these results, we have observed the potential of compound 16 as a new hit anti-inflammatory agent, and these findings could serve as a basis for further studies on its mechanism of action.

Application In Synthesis of 3-Hydroxybenzaldehyde. About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Faudzi, SMM; Abdullah, MA; Manap, MRA; Ismail, AZ; Rullah, K; Aluwi, MFFM; Ramli, ANM; Abas, F; Lajis, NH or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles