Category: 100-83-4

Authors Hussein, MA; Dinh, AH; Huynh, VT; Nguyen, TV in ROYAL SOC CHEMISTRY published article about TRIFLIC ACID; EFFICIENT; ALDEHYDES; KETONES; N,N-DIMETHYLFORMAMIDE; HYDROGENATION; FORMAMIDES; AMIDATION; ALCOHOLS in [Hussein, Mohanad A.; Dinh, An H.; Thanh Vinh Nguyen] Univ New South Wales, Sch Chem, Sydney, NSW, Australia; [Huynh, Vien T.] Univ Sydney, Sch Chem, Sydney, NSW, Australia in 2020.0, Cited 56.0. SDS of cas: 100-83-4. The Name is 3-Hydroxybenzaldehyde. Through research, I have a further understanding and discovery of 100-83-4

Tertiary amines are ubiquitous and valuable compounds in synthetic chemistry, with a wide range of applications in organocatalysis, organometallic complexes, biological processes and pharmaceutical chemistry. One of the most frequently used pathways to synthesize tertiary amines is the reductive amination reaction of carbonyl compounds. Despite developments of numerous new reductive amination methods in the past few decades, this reaction generally requires non-atom-economic processes with harsh conditions and toxic transition-metal catalysts. Herein, we report simple yet practical protocols using triflic acid as a catalyst to efficiently promote the direct reductive amination reactions of carbonyl compounds on a broad range of substrates. Applications of this new method to generate valuable heterocyclic frameworks and polyamines are also included.

SDS of cas: 100-83-4. About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Hussein, MA; Dinh, AH; Huynh, VT; Nguyen, TV or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Category: indole-building-block. Authors Tawfik, EH; Fadda, AA; Soliman, NN; Abou-Zeid, L; Negm, A in WORLD SCI PUBL CO INC published article about in [Tawfik, Eman H.] Taibah Univ, Fac Sci & Arts, Chem Dept, Ulla, Saudi Arabia; [Tawfik, Eman H.; Fadda, Ahmed A.; Soliman, Nanees N.; Negm, Amr] Mansoura Univ, Fac Sci, Chem Dept, Mansoura 35516, Egypt; [Abou-Zeid, Laila] Mansoura Univ, Fac Pharm, Dept Pharmaceut Organ Chem, Mansoura 35516, Egypt in 2019.0, Cited 30.0. The Name is 3-Hydroxybenzaldehyde. Through research, I have a further understanding and discovery of 100-83-4

A new methodology for the synthesis of a new series of mesotetrakis[aryl]-21H,23H-porphyrin derivatives 5a-5d, 6a-6c, 7 and 8 is presented. Structures of new compounds were established based on both elemental and spectral data. Cytotoxicity activity of the newly synthesized compounds was investigated against two human cell lines MCF-7 and HepG2. Molecular docking was performed to investigate the binding between the most active porphyrin derivatives and Bcl-2 molecular biomarkers in HepG2 cells.

Category: indole-building-block. About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Tawfik, EH; Fadda, AA; Soliman, NN; Abou-Zeid, L; Negm, A or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recently I am researching about ONE-POT SYNTHESIS; 1,2,4,5-TETRASUBSTITUTED IMIDAZOLES; 2,4,5-TRISUBSTITUTED IMIDAZOLES; EFFICIENT CATALYST; HETEROGENEOUS CATALYST; REUSABLE CATALYST; SOLVENT; SHELL; NANOCATALYSTS; CONDENSATION, Saw an article supported by the Semnan University Research Council. Published in SPRINGER in NEW YORK ,Authors: Arghan, M; Koukabi, N; Kolvari, E. The CAS is 100-83-4. Through research, I have a further understanding and discovery of 3-Hydroxybenzaldehyde. Quality Control of 3-Hydroxybenzaldehyde

In this study, a PVAm-bearing SO3H groups/Fe3O4 nanocomposite was prepared via a simple and in situ polymerization of acrylamide onto the surface of magnetic nanoparticles without using organosilane precursors. In order to obtain amine-functionalized magnetic, Hofmann degradation was carried out. In the following, sulfonated-polyvinyl amine coated on Fe3O4 nanoparticles was prepared by covalent grafting of chlorosulfonic acid on amine groups. The introduction of polymer to the surface of magnetic nanoparticles increases the loading content with functional groups extremely. The resulting hybrid material was effectively employed as an unprecedented acid magnetic catalyst for the one-pot synthesis of 2,4,5-trisubstituted and 1,2,4,5-tetrasubstituted imidazoles under solvent-free conditions. High yields, mild reaction conditions, short reaction times, operational simplicity with reusability are the notable features of the catalyst. The structure of the newly developed catalyst was characterized using TGA, FT-IR, SEM, TEM, VSM, EDX, CHNS, and XRD analysis. Magnetic separation and recycling of the catalyst for at least 8 runs is possible without any significant deterioration in catalytic activity. This work is the first report of employing PVAm as a linker for immobilizing liquid acid on a support.

Quality Control of 3-Hydroxybenzaldehyde. About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Arghan, M; Koukabi, N; Kolvari, E or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

I found the field of Biochemistry & Molecular Biology; Chemistry very interesting. Saw the article Targeting Receptor Tyrosine Kinase VEGFR-2 in Hepatocellular Cancer: Rational Design, Synthesis and Biological Evaluation of 1,2-Disubstituted Benzimidazoles published in 2020.0. Computed Properties of C7H6O2, Reprint Addresses Abdel-Mohsen, HT (corresponding author), Natl Res Ctr, Dept Chem Nat & Microbial Prod, Div Pharmaceut & Drug Ind Res, PO 12622, Cairo, Egypt.; El Kerdawy, AM (corresponding author), Cairo Univ, Fac Pharm, Dept Pharmaceut Chem, Kasr El Aini St,POB 11562, Cairo, Egypt.; El Kerdawy, AM (corresponding author), New Giza Univ, Fac Pharm, Dept Pharmaceut Chem, Km 22 Cairo Alexandria Desert Rd, Cairo, Egypt.; Senge, MO (corresponding author), Univ Dublin, St Jamess Hosp, Trinity Coll Dublin, Trinity Ctr Hlth Sci,Med Chem,Trinity Translat Me, Dublin 8, Ireland.. The CAS is 100-83-4. Through research, I have a further understanding and discovery of 3-Hydroxybenzaldehyde

In this study, a novel series of 1,2-disubstituted benzo[d]imidazoles was rationally designed as VEGFR-2 inhibitors targeting hepatocellular carcinoma. Our design strategy is two-fold; it aimed first at studying the effect of replacing the 5-methylfuryl moiety of the well-known antiangiogenic 2-furylbenzimidazoles with an isopropyl moiety on the VEGFR-2 inhibitory activity and the cytotoxic activity. Our second objective was to further optimize the structures of the benzimidazole derivatives through elongation of the side chains at their one-position for the design of more potent type II-like VEGFR-2 inhibitors. The designed 1,2-disubstituted benzimidazoles demonstrated potent cytotoxic activity against the HepG2 cell line, reaching IC50 = 1.98 mu M in comparison to sorafenib (IC50 = 10.99 mu M). In addition, the synthesized compounds revealed promising VEGFR-2 inhibitory activity in the HepG2 cell line, e.g., compounds 17a and 6 showed 82% and 80% inhibition, respectively, in comparison to sorafenib (% inhibition = 92%). Studying the effect of 17a on the HepG2 cell cycle demonstrated that 17a arrested the cell cycle at the G2/M phase and induced a dose-dependent apoptotic effect. Molecular docking studies of the synthesized 1,2-disubstituted benzimidazoles in the VEGFR-2 active site displayed their ability to accomplish the essential hydrogen bonding and hydrophobic interactions for optimum inhibitory activity.

Computed Properties of C7H6O2. About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Abdel-Mohsen, HT; Abdullaziz, MA; El Kerdawy, AM; Ragab, FAF; Flanagan, KJ; Mahmoud, AEE; Ali, MM; El Diwani, HI; Senge, MO or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

In 2019.0 MED CHEM published article about DRUG DISCOVERY; RESISTANCE; DESIGN in [Das, Swagatika; Gul, H. Inci; Das, Umashankar; Dimmock, Jonathan R.] Univ Saskatchewan, Drug Discovery & Dev Res Grp, Coll Pharm & Nutr, 104 Clin Pl, Saskatoon, SK S7N 2Z5, Canada; [Balzarini, Jan] Katholieke Univ Leuven, Rega Inst Med Res, B-3000 Leuven, Belgium; [Dimmock, Stephen G.] Nanyang Technol Univ, Dept Finance, Singapore 539798, Singapore in 2019.0, Cited 26.0. The Name is 3-Hydroxybenzaldehyde. Through research, I have a further understanding and discovery of 100-83-4. SDS of cas: 100-83-4

Background: Cancer continues to be the major health burden worldwide. There is an urgent need for the development of novel antineoplastic compounds to treat this devastating condition. Various alkylating anticancer drugs have been employed in the clinic for treating cancers. Unsaturated conjugated ketones are a group of alkylators which are of significant interest as potent antineoplastic agents. Objective: The goal of this study is to discover unsaturated conjugated ketones which are novel potent cytotoxins displaying growth-inhibitory properties towards neoplasms and also to serve as cytotoxic warheads in drug development. Methods: A variety of 3,5-bis (benzylidene)-4-piperidones 2a-n were synthesized and evaluated against a number of neoplastic cell lines. The short-term neurotoxicity of 2a-k, n was evaluated in mice by i.p. administration using doses level of 30, 100 and 300 mg/kg. Statistical correlations for determining structure-activity relationships were performed using an SPSS software. Results: A number of compounds display cytotoxic potencies in the region of 10(-7) to 10(-8) M and some of the structural features contributing to the cytotoxicity were identified. Compounds 2a-d, 2h demonstrated substantially higher cytotoxic potencies compared to melphalan and 5-fluorouracil against a panel of leukemic and colon cancer cell lines. These lead cytotoxins comply with drug-likeness properties. In general, the antineoplastics 2 are well tolerated in mice using a short-term neurotoxicity screening. Conclusion: In general, this group of compounds comprises excellent cytotoxic agents, which warrant their further development as cytotoxic warheads.

SDS of cas: 100-83-4. About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Das, S; Gul, HI; Das, U; Balzarini, J; Dimmock, SG; Dimmock, JR or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Design, synthesis and biological activity of novel 2,3,4,5-tetra-substituted thiophene derivatives as PI3K alpha inhibitors with potent antitumor activity WOS:000533524000003 published article about PI3K INHIBITORS; DISCOVERY; PATHWAY; NVP-BYL719; TARGET in [Liao, Weike; Lei, Qiancheng; Chen, Rui; Tang, Lei] Guizhou Med Univ, Guizhou Prov Engn Technol Res Ctr Chem Drug R&D, State Key Lab Funct & Applicat Med Plants, Guiyang 550004, Peoples R China; [Wang, Zhongyuan; Xie, Juan] Guizhou Prov Peoples Hosp, Dept Pharm, Guiyang 550002, Peoples R China; [Han, Yufei; Qi, Yinliang; Tian, Ye; Sun, Ming; Zhao, Yanfang] Shenyang Pharmaceut Univ, Minist Educ, Key Lab Struct Based Drug Design & Discovery, 103 Wenhua Rd, Shenyang 110016, Peoples R China; [Gong, Guowei] Zunyi Med Univ, Dept Bioengn, Zhuhai Campus, Zhuhai 519041, Guangdong, Peoples R China; [Liu, Jiaan] Univ Massachusetts Amherst, Dept Chem, Amherst, MA 01003 USA in 2020.0, Cited 25.0. Formula: C7H6O2. The Name is 3-Hydroxybenzaldehyde. Through research, I have a further understanding and discovery of 100-83-4

Using a rational design strategy for isoform-selective inhibition of PI3K alpha, two series of novel 2,3,4,5-tetra-substituted thiophene derivatives containing either diaryl urea or N-Acylarylhydrazone scaffold were designed and synthesized. The most promising compound 12k was demonstrated to bear nanomolar PI3K alpha inhibitory potency with 12, 28, 30, 196-fold selectivity against isoforms beta, gamma, delta and mTOR. Besides, it also showed good developability profiles in cell-based proliferation against a panel of human tumor cells as well as ADME assays. We herein report on their design, synthesis, SAR and potential developability properties. (C) 2020 Elsevier Masson SAS. All rights reserved.

Formula: C7H6O2. About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Liao, WK; Wang, ZY; Han, YF; Qi, YL; Liu, JA; Xie, J; Tian, Y; Lei, QC; Chen, R; Sun, M; Tang, L; Gong, GW; Zhao, YF or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

SDS of cas: 100-83-4. Authors Pommidi, A; Shaik, AB; Chatterjee, A; Somarapu, VL in SPRINGER published article about in [Shaik, Asha Begum; Somarapu, Vijaya Laxmi] Palamuru Univ, Dept Chem, Mahabubnagar 509001, Telangana, India; [Pommidi, Anil; Chatterjee, Anindita] Koneru Lakshmaiah Educ Fdn, Dept Chem, Guntur 522502, Andhra Pradesh, India in 2020.0, Cited 21.0. The Name is 3-Hydroxybenzaldehyde. Through research, I have a further understanding and discovery of 100-83-4

Novel and efficient method for the synthesis of a series of beta,gamma-unsaturated-alpha-ketoesters under mild conditions was developed. This one-step protocol was achieved by the reaction of electron-rich aromatic aldehydes and pyruvates in the presence of 10 mol% of molecular iodine in solvent-free condition at 80 degrees C temperature. A wide variety of substrates bearing electron releasing groups on aromatic ring were well tolerated and delivered corresponding beta,gamma-unsaturated-alpha-ketoesters in moderate to good yields. These beta,gamma-unsaturated-alpha-ketoesters have been further utilized in the synthesis of 4,5-dihydropyrazole derivatives. [GRAPHICS] .

SDS of cas: 100-83-4. About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Pommidi, A; Shaik, AB; Chatterjee, A; Somarapu, VL or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

COA of Formula: C7H6O2. In 2020.0 RSC ADV published article about CYSTEINE PROTEASE INHIBITORS; STABILITY in [Alves, Marina A.; Barreiro, Eliezer J.; Lima, Lidia M.] Univ Fed Rio De Janeiro UFRJ, Lab Avaliacao & Sintese Subst Bioativas LASSBio, Inst Nacl Ciencia & Tecnol Farmacos & Medicamento, CCS, POB 68023, BR-21941902 Rio De Janeiro, RJ, Brazil; [Alves, Marina A.; Barreiro, Eliezer J.; Lima, Lidia M.] Univ Fed Rio de Janeiro, Inst Quim, Programa Posgrad Quim, BR-21941909 Rio de Janeiro, RJ, Brazil; [de Queiroz, Aline C.; Leite, Anderson Brandao; Alexandre-Moreira, Magna S.] Univ Fed Alagoas UFAL, Inst Ciencias Biol & Sande, Lab Farmacol & Imunol, BR-57072900 Maceio, AL, Brazil; [Martins, Felipe T.; Doriguetto, Antonio C.] Univ Fed Goias, Inst Quim, Campus Samambaia,CP 131, BR-74001970 Goiania, Go, Brazil in 2020.0, Cited 33.0. The Name is 3-Hydroxybenzaldehyde. Through research, I have a further understanding and discovery of 100-83-4.

Leishmaniasis is a neglected parasitic disease, and current treatment includes limitations of toxicity, variable efficacy, high costs and inconvenient doses and treatment schedules. Therefore, new leishmanicidal drugs are still an unquestionable medical need. In this paper we described the design conception of a new framework, the carbamoyl-N-aryl-imine-urea, to obtain putative leishmanicidal drug-candidates. Compounds 9a-e and 10a-e were designed and synthesized and their leishmanicidal activity was studied in comparison to pentamidine, miltefosine and meglumine antimoniate. The conformational profile of the new carbamoyl-N-aryl-imine-urea framework was investigated by X-ray diffraction studies, using compound 9a as a model. The plasma stability of this putative peptide mimetic subunit was studied for compound 10e (LASSBio-1736). Among the congeneric series, LASSBio-1736 was identified as a new antileishmanial drug-candidate, displaying plasma stability, cytotoxicity against amastigote forms of L. amazonensis and L. braziliensis, and leishmanicidal activity in a cutaneous leishmaniasis murine model, without preliminary evidence of hepatic or renal toxicity.

COA of Formula: C7H6O2. About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Alves, MA; de Queiroz, AC; Leite, AB; Martins, FT; Doriguetto, AC; Barreiro, EJ; Alexandre-Moreira, MS; Lima, LM or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Computed Properties of C7H6O2. In 2020.0 BIOORG MED CHEM LETT published article about ANTIFUNGAL; LIPOPHILICITY in [Stingaci, Eugenia; Zveaghinteva, Marina; Pogrebnoi, Serghei; Lupascu, Lucian; Macaev, Fliur] Inst Chem, Lab Organ Synth & Biopharmaceut, 3 Str Acad, Kishinev, Moldova; [Valica, Vladimir; Uncu, Livia; Smetanscaia, Anastasia; Drumea, Maricica; Macaev, Fliur] Nicolae Testemitanu State Univ Med & Pharm, Sci Ctr Drug Res, Kishinev, Moldova; [Petrou, Anthi; Geronikaki, Athina] Aristotle Univ Thessaloniki, Dept Pharm, Sch Hlth, Thessaloniki 54124, Greece; [Ciric, Ana; Glamoclija, Jasmina; Sokovic, Marina] Univ Belgrade, Natl Inst Republ Serbia, Inst Biol Res Sinisa Stankovic, Dept Plant Physiol, Bulevar Despota Stefana 142, Belgrade 11000, Serbia; [Kravtsov, Victor] Inst Appl Phys, Lab Phys Methods Solid State Invest Tadeusz Malin, 5 Str Acad, Kishinev, Moldova in 2020.0, Cited 23.0. The Name is 3-Hydroxybenzaldehyde. Through research, I have a further understanding and discovery of 100-83-4.

1,2,4-Triazole is a very important scaffold in medicinal chemistry due to the wide spectrum of biological activities and mainly antifungal activity of 1,2,4-triazole derivatives. The main mechanism of antifungal action of the latter is inhibition of 14-alpha-demethylase enzyme (CYP51). The current study presents synthesis and evaluation of eight triazole derivatives for their antimicrobial activity. Docking studies to elucidate the mechanism of action were also performed. The designed compounds were synthesized using classical methods of organic synthesis. The in vivo evaluation of antimicrobial activity was performed by microdilution method. All tested compounds showed good antibacterial activity with MIC and MBC values ranging from 0.0002 to 0.0069 mM. Compound 2 h appeared to be the most active among all tested with MIC at 0.0002-0.0033 mM and MBC at 0.0004-0.0033 mM followed by compounds 2f and 2g. The most sensitive bacterium appeared to be Xanthomonas campestris while Erwinia amylovora was the most resistant. The evaluation of antifungal activity revealed that all compounds showed good antifungal activity with MIC values ranging from 0.02 mM to 0.52 mM and MFC from 0.03 mM to 0.52 mM better than reference drugs ketoconazole (MIC and MFC values at 0.28-1.88 mM and 0.38 mM to 2.82 mM respectively) and bifonazole (MIC and MFC values at 0.32-0.64 mM and 0.64-0.81 mM). The best antifungal activity is displayed by compound 2 h with MIC at 0.02-0.04 mM and MFC at 0.03-0.06 mM while compound 2a showed the lowest activity. The results showed that these compounds could be lead compounds in search for new potent antimicrobial agents. Docking studies confirmed experimental results.

Computed Properties of C7H6O2. About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Stingaci, E; Zveaghinteva, M; Pogrebnoi, S; Lupascu, L; Valica, V; Uncu, L; Smetanscaia, A; Drumea, M; Petrou, A; Ciric, A; Glamoclija, J; Sokovic, M; Kravtsov, V; Geronikaki, A; Macaev, F or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recently I am researching about NATURAL-PRODUCTS; INHIBITORS; DERIVATIVES; MECHANISM, Saw an article supported by the . Computed Properties of C7H6O2. Published in MAIK NAUKA/INTERPERIODICA/SPRINGER in NEW YORK ,Authors: Kuranov, SO; Blokhin, ME; Borisov, SA; Khvostov, MV; Luzina, OA; Salakhutdinov, NF. The CAS is 100-83-4. Through research, I have a further understanding and discovery of 3-Hydroxybenzaldehyde

A series of amides based on (2S)-cyanopyrrolidine and alpha, beta-unsaturated aryl- and hetarylcarboxylic acids have been synthesized. The dependence of the hypoglycemic activity of compounds on the structure of the aromatic fragment has been studied in the oral glucose tolerance test in mice. Amides based on (E)-3-phenylprop-2-enoic and (E)-3-(4-methoxyphenyl)prop-2-enoic acids and (2S)-cyanopyrrolidine have been shown to significantly reduce blood glucose levels in mice. The observed hypoglycemic effect at a dose of 10 mg/kg is comparable to the effect of hypoglycemic drug vildagliptin.

Computed Properties of C7H6O2. About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Kuranov, SO; Blokhin, ME; Borisov, SA; Khvostov, MV; Luzina, OA; Salakhutdinov, NF or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles