Category: 100-83-4

Recommanded Product: 100-83-4. Sahoo, SR; Sarkar, D in [Sahoo, Sushree Ranjan; Sarkar, Debayan] Natl Inst Technol, Dept Chem, Rourkela 769008, Odisha, India published Revisiting the Addition of in-situ Nucleophiles to Allenic Ketones: An Entry Towards Synthesis of Benzodioxins in 2020.0, Cited 40.0. The Name is 3-Hydroxybenzaldehyde. Through research, I have a further understanding and discovery of 100-83-4.

The manuscript delineates a revisit towards regioselective addition of in situ generated negative nucleophiles to allenic ketones in the presence of a base. A wide variety of allenic ketones as well as nucleophiles are viable in this transformation. A direct ring annulation towards the challenging benzodioxin skeleton synthesis has been developed. Environmentally benign protocol and wide substrate scope are the notable features of this methodology.

About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Sahoo, SR; Sarkar, D or concate me.. Recommanded Product: 100-83-4

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

COA of Formula: C7H6O2. I found the field of Chemistry very interesting. Saw the article Structure-Based Design of Dimeric Bisbenzimidazole Inhibitors to an Emergent Trimethoprim-Resistant Type II Dihydrofolate Reductase Guides the Design of Monomeric Analogues published in 2019.0, Reprint Addresses Pelletier, JN (corresponding author), Univ Montreal, Dept Biochim, Montreal, PQ H3C 3J7, Canada.; Pelletier, JN (corresponding author), Univ Montreal, Dept Chim, Montreal, PQ H3C 3J7, Canada.; Pelletier, JN (corresponding author), PROTEO, Quebec Network Res Prot Funct Engn & Applicat, Quebec City, PQ G1V 0A6, Canada.; Pelletier, JN (corresponding author), CGCC, Montreal, PQ H3A 0B8, Canada.. The CAS is 100-83-4. Through research, I have a further understanding and discovery of 3-Hydroxybenzaldehyde.

The worldwide use of the broad-spectrum antimicrobial trimethoprim (TMP) has induced the rise of TMP-resistant microorganisms. In addition to resistance-causing mutations of the microbial chromosomal dihydrofolate reductase (Dfr), the evolutionarily and structurally unrelated type II Dfrs (DfrBs) have been identified in TMP-resistant microorganisms. DfrBs are intrinsically TMP-resistant and allow bacterial proliferation when the microbial chromosomal Dfr is TMP-inhibited, making these enzymes important targets for inhibitor development. Furthermore, DfrBs occur in multiresistance plasmids, potentially accelerating their dissemination. We previously reported symmetrical bisbenzimidazoles that are the first selective inhibitors of the only well-characterized DfrB, DfrB1. Here, their diversification provides a new series of inhibitors (K-i = 1.7-12.0 mu M). Our results reveal two prominent features: terminal carboxylates and inhibitor length allow the establishment of essential interactions with DfrB1. Two crystal structures demonstrate the simultaneous binding of two inhibitor molecules in the symmetrical active site. Observations of those dimeric inhibitors inspired the design of monomeric analogues, binding in a single copy yet offering similar inhibition potency (K-i = 1.1 and 7.4 mu M). Inhibition of a second member of the DfrB family, DfrB4, suggests the generality of these inhibitors. These results provide key insights into inhibition of the highly TMP-resistant DfrBs, opening avenues to downstream development of antibiotics for combatting this emergent source of resistance.

About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Toulouse, JL; Yachnin, BJ; Ruediger, EH; Deon, D; Gagnon, M; Saint-Jacques, K; Ebert, MCCJC; Forge, D; Bastien, D; Colin, DY; Eynde, JJV; Marinier, A; Berghuis, AM; Pelletier, JN or concate me.. COA of Formula: C7H6O2

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

COA of Formula: C7H6O2. In 2019.0 J MOL STRUCT published article about METAL-ORGANIC FRAMEWORKS; ONE-POT SYNTHESIS; MULTICOMPONENT SYNTHESIS; 3-COMPONENT SYNTHESIS; NANOPARTICLES; ANTIOXIDANT; ACID; MOFS in [Ghaffarian, Fatemeh; Ghasemzadeh, Mohammad Ali] Islamic Azad Univ, Dept Chem, Qom Branch, Qom, Iran; [Aghaei, Seyyed Soheil] Islamic Azad Univ, Dept Microbiol, Qom Branch, Qom, Iran in 2019.0, Cited 53.0. The Name is 3-Hydroxybenzaldehyde. Through research, I have a further understanding and discovery of 100-83-4.

( )Curcumin (bis-alpha,beta-unsaturated beta-diketone) is a low molecular weight hydrophobic polyphenol isolated from Curcuma longa. Curcumin has attracted significant recent consideration due to its medicinal and pharmacological properties. In this research pyrano[2,3-d]pyrimidine-2,4(3H)-dione derivatives were prepared in excellent yields and short reaction times by a one-pot multi-component cyclocondensation of curcumin, substituted aromatic aldehydes and barbituric acid in the presence of CoFe2O4@OCMC@Cu(BDC) nanostructure as an effective and robust catalyst. The CoFe2O4 functionalized OCMC@Cu(BDC) is introduced as a new, strong and efficient catalyst for the synthesis of a variety of heterocyclic compounds. The catalyst was perfectly characterized by various spectroscopy methods such as Fouriertransform infrared spectroscopy (FT-IR), Energy-dispersive X-ray (EDX), Scanning electron microscope (SEM), X-ray diffraction (XRD) and N2 adsorption-desorption isotherm (BET). Furthermore, the heterocyclic compounds were fully characterized by different spectral techniques including FT-IR, (HNMR)-H-1, (CNMR)-C-13. The magnetic catalyst could be easily recycled and reused for seven runs with a slightly decrease in its activity. (C) 2019 Elsevier B.V. All rights reserved.

COA of Formula: C7H6O2. About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Ghaffarian, F; Ghasemzadeh, MA; Aghaei, SS or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Quality Control of 3-Hydroxybenzaldehyde. Recently I am researching about PROCESS WINDOWS; CHEMISTRY; REACTORS; LIQUID; SAFE, Saw an article supported by the Spanish MINECO [RTI2018-095588-B-I00]; European Regional Development Fund/European Social Fund, Investing in your future; FUSP-CEU [PC17/17]; Fundacion San Pablo-CEU. Published in ROYAL SOC CHEMISTRY in CAMBRIDGE ,Authors: Garcia-Lacuna, J; Dominguez, G; Blanco-Urgoiti, J; Perez-Castells, J. The CAS is 100-83-4. Through research, I have a further understanding and discovery of 3-Hydroxybenzaldehyde

A new synthesis of treprostinil is described using a plug flow reactor in two of the key steps. First, a Claisen rearrangement reaction is described in scaled flow at multigram amounts. Yields and selectivity of this step are sharply improved compared to those from previous syntheses. Second, the key Pauson-Khand reaction in flow is described under catalytic conditions with 5 mol% of cobalt carbonyl and only 3 equiv. of CO. Scaling up of this reaction safely ensures a good yield of an advanced intermediate which is transformed into treprostinil in three steps. Other improvements are the introduction of the carboxymethyl chain into the phenol from the beginning to reduce the protection-deprotection steps. The synthesis is completed in 14% global yield after 12 linear steps from (S)-epichlorhydrin.

Quality Control of 3-Hydroxybenzaldehyde. About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Garcia-Lacuna, J; Dominguez, G; Blanco-Urgoiti, J; Perez-Castells, J or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recommanded Product: 3-Hydroxybenzaldehyde. I found the field of Biochemistry & Molecular Biology very interesting. Saw the article A drug discovery platform to identify compounds that inhibit EGFR triple mutants published in 2020.0, Reprint Addresses Stagljar, I (corresponding author), Univ Toronto, Donnelly Ctr, Toronto, ON, Canada.; Stagljar, I (corresponding author), Univ Toronto, Dept Mol Genet, Toronto, ON, Canada.; Stagljar, I (corresponding author), Univ Toronto, Dept Biochem, Toronto, ON, Canada.; Stagljar, I (corresponding author), Mediterranean Inst Life Sci, Split, Croatia.. The CAS is 100-83-4. Through research, I have a further understanding and discovery of 3-Hydroxybenzaldehyde.

Receptor tyrosine kinases (RTKs) are transmembrane receptors of great clinical interest due to their role in disease. Historically, therapeutics targeting RTKs have been identified using in vitro kinase assays. Due to frequent development of drug resistance, however, there is a need to identify more diverse compounds that inhibit mutated but not wild-type RTKs. Here, we describe MaMTH-DS (mammalian membrane two-hybrid drug screening), a live-cell platform for high-throughput identification of small molecules targeting functional protein-protein interactions of RTKs. We applied MaMTH-DS to an oncogenic epidermal growth factor receptor (EGFR) mutant resistant to the latest generation of clinically approved tyrosine kinase inhibitors (TKIs). We identified four mutant-specific compounds, including two that would not have been detected by conventional in vitro kinase assays. One of these targets mutant EGFR via a new mechanism of action, distinct from classical TKI inhibition. Our results demonstrate how MaMTH-DS is a powerful complement to traditional drug screening approaches.

Recommanded Product: 3-Hydroxybenzaldehyde. About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Saraon, P; Snider, J; Kalaidzidis, Y; Wybenga-Groot, LE; Weiss, K; Rai, A; Radulovich, N; Drecun, L; Vuckovic, N; Vucetic, A; Wong, V; Theriault, B; Pham, NA; Park, JH; Datti, A; Wang, J; Pathmanathan, S; Aboualizadeh, F; Lyakisheva, A; Yao, Z; Wang, YH; Joseph, B; Aman, A; Moran, MF; Prakesch, M; Poda, G; Marcellus, R; Uehling, D; Samarzija, M; Jakopovic, M; Tsao, MS; Shepherd, FA; Sacher, A; Leighl, N; Akhmanova, A; Al-awar, R; Zerial, M; Stagljar, I or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Application In Synthesis of 3-Hydroxybenzaldehyde. I found the field of Chemistry very interesting. Saw the article Synthesis of coumarin based Knoevenagel-Ugi adducts by a sequential one pot five-component reaction and their biological evaluation as anti-bacterial agents published in 2019.0, Reprint Addresses Singh, V (corresponding author), Deemed Be Univ, Dept Appl Sci, Punjab Engn Coll, Sect 12, Chandigarh 160012, India.. The CAS is 100-83-4. Through research, I have a further understanding and discovery of 3-Hydroxybenzaldehyde.

An efficient multicomponent synthesis of Ugi compounds comprising coumarin backbone has been achieved by employing one pot five component sequential Knoevenagel-Ugi reaction. This method offers the advantages of easy handling procedure, atom economy, mild reaction conditions and good yields of products. A molecular library was synthesized by changing the substituents on two of the independent starting materials. The synthesized compounds were also tested for anti-microbial activities and were found to be moderate to good anti-bacterial agents. (C) 2018 Elsevier Ltd. All rights reserved.

Application In Synthesis of 3-Hydroxybenzaldehyde. About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Kumar, S; Mukesh, K; Harjai, K; Singh, V or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recently I am researching about GLUCOSIDASE INHIBITORS; BIOLOGICAL EVALUATION; IN-SILICO; ANALOGS, Saw an article supported by the . Published in ACADEMIC PRESS INC ELSEVIER SCIENCE in SAN DIEGO ,Authors: Taha, M; Rahim, F; Zaman, K; Selvaraj, M; Uddin, N; Farooq, RK; Nawaz, M; Sajid, M; Nawaz, F; Ibrahim, M; Khan, KM. The CAS is 100-83-4. Through research, I have a further understanding and discovery of 3-Hydroxybenzaldehyde. Product Details of 100-83-4

A series of twenty-six analogs of benzimidazole based oxadiazole have been synthesized and evaluated against alpha-glycosidase enzyme. Most the analogs showed excellent to good inhibitory potential. Among the screened analogs, analog 1, 2, 3 and 14 with IC50 values 4.6 +/- 0.1, 9.50 +/- 0.3, 2.6 +/- 0.1 and 9.30 +/- 0.4 mu M respectively showedexcellent inhibitory potential than reference drug acarbose (IC50 = 38.45 +/- 0.80 mu M). Some of the analogs like 19, 21, 22 and 23 with methyl and methoxy substituent on phenyl ring show hydrophobic interaction and were found with no inhibitory potential. The binding interactions between synthesized analogs and ligands protein were confirmed through molecular docking study. Various spectroscopic techniques like H-1 NMR, C-13 NMR, and EI-MS were used for characterization of all synthesized analogs. These derivatives were synthesized by simple mode of synthesis like heterocyclic ring formation.

Product Details of 100-83-4. About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Taha, M; Rahim, F; Zaman, K; Selvaraj, M; Uddin, N; Farooq, RK; Nawaz, M; Sajid, M; Nawaz, F; Ibrahim, M; Khan, KM or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Computed Properties of C7H6O2. In 2020.0 J MOL LIQ published article about CORRELATION-ENERGY; SYSTEM; DEHYDRATION; NAPHTHALENE; OXIMES; WATER; DNA in [Das, Debadutta] Sukanti Degree Coll, Dept Chem, Subarnapur, Odisha, India; [Sarangi, Ashish K.] Centurion Univ Technol & Management, Sch Appl Sci, Dept Chem, R Sitapur, Odisha, India; [Mohapatra, Ranjan K.] Govt Coll Engn, Dept Chem, Keonjhar, Odisha, India; [Parhi, Pankaj K.] KIIT Deemed Be Univ, Sch Chem Technol, Bhubaneswar, Odisha, India; [Parhi, Pankaj K.] Korea Inst Geosci & Mineral Resources KIGAM, Convergence Res Ctr Dev Mineral Resources DMR, Daejeon, South Korea; [Mahal, Ahmed] Chinese Acad Sci, Key Lab Plant Resources Conservat & Sustainable U, South China Bot Garden, Guangzhou 510650, Peoples R China; [Mahal, Ahmed] Chinese Acad Sci, Guangdong Prov Key Lab Appl Bot, South China Bot Garden, Guangzhou 510650, Peoples R China; [Mahal, Ahmed] Guangzhou HC Pharmaceut Co Ltd, Guangzhou 510663, Peoples R China; [Sahu, Raghaba] Seoul Natl Univ, Coll Pharm, Seoul, South Korea; [Kudrat-E-Zahan, Md] Rajshahi Univ, Dept Chem, Rajshahi 6205, Bangladesh in 2020.0, Cited 36.0. The Name is 3-Hydroxybenzaldehyde. Through research, I have a further understanding and discovery of 100-83-4.

This article describes a green method for regeneration of carbonyl compounds from various types of oxime compounds under microwave radiation using I-2 and aqueous saponin solution isolated from Shikakai. Effect of saponin concentration on yield percentage of regenerated different types of carbonyl compounds has been discussed. A correlation has been established between saponin concentration and yield percentage of carbonyl compounds. Mechanism of interaction between oxime and saponin is established on the basis of density functional theory. In addition, the quantum chemical parameters for saponin have been determined. Furthermore, electrostatic surface analysis of the saponin is carried out to confirm the mechanism of interaction between saponin and oximes. (C) 2020 Elsevier B.V. All rights reserved.

Computed Properties of C7H6O2. About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Das, D; Sarangi, AK; Mohapatra, RK; Parhi, PK; Mahal, A; Sahu, R; Kudrat-E-Zahan, M or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article C3 amino-substituted chalcone derivative with selective adenosine rA(1) receptor affinity in the micromolar range WOS:000590271200001 published article about ALPHA-KETO ACIDS; DRUG DISCOVERY; ANTIPROLIFERATIVE ACTIVITY; BIOLOGICAL-ACTIVITIES; INTERNATIONAL UNION; SCREENING LIBRARIES; ANTAGONIST; INHIBITORS; BRAIN; BINDING in [Janse van Rensburg, Helena D.; Legoabe, Lesetja J.; Terre’Blanche, Gisella] North West Univ, Ctr Excellence Pharmaceut Sci, Private Bag X6001, ZA-2520 Potchefstroom, South Africa; [Terre’Blanche, Gisella] Northwest Univ, Sch Pharm, Pharmaceut Chem, Private Bag X6001, ZA-2520 Potchefstroom, South Africa in 2021.0, Cited 124.0. SDS of cas: 100-83-4. The Name is 3-Hydroxybenzaldehyde. Through research, I have a further understanding and discovery of 100-83-4

To identify novel adenosine receptor (AR) ligands based on the chalcone scaffold, herein the synthesis, characterization and in vitro and in silico evaluation of 33 chalcones (15-36 and 37-41) and structurally related compounds (42-47) are reported. These compounds were characterized by radioligand binding and GTP shift assays to determine the degree and type of binding affinity, respectively, against rat (r) A(1) and A(2A) ARs. The chalcone derivatives 24, 29, 37 and 38 possessed selective A(1) affinity below 10 mu M, and thus, are the most active compounds of the present series; compound 38 was the most potent selective A(1) AR antagonist (K-i (r) = 1.6 mu M). The structure-affinity relationships (SAR) revealed that the NH2-group at position C3 of ring A of the chalcone scaffold played a key role in affinity, and also, the Br-atom at position C3 ‘ on benzylidene ring B. Upon in vitro and in silico evaluation, the novel C3 amino-substituted chalcone derivative 38-that contains an alpha,ss-unsaturated carbonyl system and easily allows structural modification-may possibly be a synthon in future drug discovery. [GRAPHICS] .

About 3-Hydroxybenzaldehyde, If you have any questions, you can contact van Rensburg, HDJ; Legoabe, LJ; Terre’Blanche, G or concate me.. SDS of cas: 100-83-4

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Quality Control of 3-Hydroxybenzaldehyde. In 2019.0 EUR J MED CHEM published article about FATTY-ACID SYNTHASE; EPIGALLOCATECHIN GALLATE; NATURAL INHIBITOR; OVEREXPRESSION; POLYPHENOLS; ACTIVATION; APOPTOSIS; PATHWAY; KINASE; GROWTH in [Tan, Yu-Jia; Tee, Sheng-Yang; Lam, Yulin] Natl Univ Singapore, Dept Chem, 3 Sci Dr 3, Singapore 117543, Singapore; [Tan, Yu-Jia; Teo, Jun -Ting] Yong Loo Lin Sch Med, Canc Sci Inst Singapore, 14 Med Dr, Singapore 117599, Singapore; [Xi, Yu; Go, Mei-Lin] Natl Univ Singapore, Dept Pharm, 18 Sci Dr 4, Singapore 117543, Singapore in 2019.0, Cited 55.0. The Name is 3-Hydroxybenzaldehyde. Through research, I have a further understanding and discovery of 100-83-4.

Fatty acid synthase (FASN) is a lipogenic enzyme that is selectively upregulated in malignant cells. There is growing consensus on the oncogenicity of FASN-driven lipogenesis and the potential of FASN as a druggable target in cancer. Here, we report the synthesis and FASN inhibitory activities of two novel galloyl esters of trans-stilbene EC1 and EC5. Inhibition of FASN was accompanied by a loss in AKT activation and profound apoptosis in several non-small cell lung cancer (NSCLC) cells at the growth inhibitory concentrations of EC1 and EC5. Both FASN and phospho-AKT levels were concurrently downregulated. However, addition of a lipid concentrate to the treated cells reinstated cell viability and reversed the loss of FASN and AKT protein levels, thus recapitulating the causal relationship between FASN inhibition and the loss in cell viability. (C) 2019 Elsevier Masson SAS. All rights reserved.

About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Tan, YJ; Ali, A; Tee, SY; Teo, JT; Xi, Y; Go, ML; Lam, YL or concate me.. Quality Control of 3-Hydroxybenzaldehyde

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles