Category: 100-83-4

Pandrala, M; Resendez, A; Malhotra, SV in [Pandrala, Mallesh; Resendez, Angel; Malhotra, Sanjay V.] Stanford Univ, Sch Med, Dept Radiat Oncol, Palo Alto, CA 94304 USA published Polypyridyl iridium(III) based catalysts for highly chemoselective hydrogenation of aldehydes in 2019.0, Cited 53.0. SDS of cas: 100-83-4. The Name is 3-Hydroxybenzaldehyde. Through research, I have a further understanding and discovery of 100-83-4.

Iridium-catalyzed transfer hydrogenation (TH) of carbonyl compounds using HCOOR (R = H, Na, NH4) as a hydrogen source is a pivotal process as it provides the clean process and is easy to execute. However, the existing highly efficient iridium catalysts work at a narrow pH; thus, does not apply to a wide variety of substrates. Therefore, the development of a new catalyst which works at a broad pH range is essential as it can gain a broader scope of utilization. Here we report highly efficient polypyridyl iridium(III) catalysts, [Ir(tPY)(L)Cl](PF6)(2) (where tpy = 2,2′:6′,2-Terpyridine, L = phen (1,10-Phenanthroline), Me(2)phen (4,7-Di methyl-1,10-phenanthroline), Me(4)phen (3,4,7,8-Tetramethyl-1,10-phenanthroline), Me(2)bpy (4,4′-Dimet hyl-2-2′-dipyridyl)) for the chemoselective reduction of aldehydes to alcohols in aqueous ethanol and sodium formate as the hydride source. The reaction can be carried out efficiently in broad pH ranges, from pH 6 to 11. These catalysts are air stable, easy to prepare using commercially available starting materials, and are highly applicable for a wide range of substrates, such as electron-rich or deficient (hetero)arenes, halogens, phenols, alkoxy, ketones, esters, carboxylic acids, cyano, and nitro groups. Particularly, acid and hydroxy groups containing aldehydes were reduced successfully in basic and acidic reaction conditions, demonstrating the efficiency of the catalyst in a broad pH range with high conversion rates under microwave irradiation. (C) 2019 Elsevier Inc. All rights reserved.

SDS of cas: 100-83-4. About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Pandrala, M; Resendez, A; Malhotra, SV or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

I found the field of Pharmacology & Pharmacy very interesting. Saw the article Dipropargyl substituted diphenylpyrimidines as dual inhibitors of monoamine oxidase and acetylcholinesterase published in 2019.0. HPLC of Formula: C7H6O2, Reprint Addresses Kumar, V (corresponding author), Cent Univ Punjab, Dept Pharmaceut Sci & Nat Prod, Lab Organ & Med Chem, Bathinda 151001, Punjab, India.; Parkash, J (corresponding author), Cent Univ Punjab, Sch Basic & Appl Sci, Dept Anim Sci, Bathinda, Punjab, India.. The CAS is 100-83-4. Through research, I have a further understanding and discovery of 3-Hydroxybenzaldehyde

Alzheimer’s disease (AD) is a multifactorial neurological disorder involving complex pathogenesis. Single target directed drugs proved ineffective and since last few years’ different pharmacological strategies including multi-targeting agents are being explored for the effective drug development for AD. A total of 19 dipropargyl substituted diphenylpyrimidines have been synthesized and evaluated for the monoamine oxidase (MAO) and acetylcholinesterase (AChE) inhibition potential. All the compounds were found to be selective and reversible inhibitors of MAO-B isoform. These compounds also displayed good AChE inhibition potential with IC50 values in low micromolar range. AVB4 was found to be the most potent MAO-B inhibitor with IC50 value of 1.49 +/- 0.09 mu M and AVB1 was found to be the most potent AChE inhibitor with IC50 value of 135 +/- 0.03 mu M. In the ROS protection inhibition studies, AVB1 and AVB4 displayed weak but interesting activity in SH-SYSY cells. In the cytotoxicity studies involving SH-SY5Y cells, both AVB1 and AVB4 were found to be non-toxic to the tissue cells. In the molecular dynamic simulation studies of 30 ns, the potent compounds were found to be quite stable in the active site of MAO-B and AChE. The results suggested that AVB1 and AVB4 are promising dual inhibitors and have the potential to be developed as anti-Alzheimer’s drug. (C) 2019 Published by Elsevier Masson SAS.

HPLC of Formula: C7H6O2. About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Kumar, B; Kumar, V; Prashar, V; Saini, S; Dwivedi, AR; Bajaj, B; Mehta, D; Parkash, J; Kumar, V or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recently I am researching about ASYMMETRIC TRANSFER HYDROGENATION; ENANTIOSELECTIVE TRANSFER HYDROGENATION; NICKEL-COMPLEXES; IRON CATALYSTS; COBALT; RUTHENIUM; REDUCTION; EFFICIENT; LIGANDS; BONDS, Saw an article supported by the Nazarbayev University via NU-ORAU grant [2016023]; Nazarbayev University via FDCRG grant [240919FD3911]. Formula: C7H6O2. Published in ROYAL SOC CHEMISTRY in CAMBRIDGE ,Authors: Segizbayev, M; Oztopcu, O; Hayrapetyan, D; Shakhman, D; Lyssenko, KA; Khalimon, AY. The CAS is 100-83-4. Through research, I have a further understanding and discovery of 3-Hydroxybenzaldehyde

The aminophosphinite pincer complex (POCNH)NiBr was found to effectively catalyze the transfer hydrogenation of aldehydes and ketones with 2-propanol and (KOBu)-Bu-t as a base, presenting a rare example of bifunctional nickel transfer hydrogenation catalysts. The transfer hydrogenation of aldehydes and ketones was found to be selective, tolerating a wide range of other functional groups, including those prone to reduction, such as esters, amides, alkenes, pyridines, and nitriles. The reactions were suggested to proceed via the metal-ligand cooperative mechanism with an intermediacy of an amido (POCN)Ni-II species.

About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Segizbayev, M; Oztopcu, O; Hayrapetyan, D; Shakhman, D; Lyssenko, KA; Khalimon, AY or concate me.. Formula: C7H6O2

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

SDS of cas: 100-83-4. I found the field of Chemistry very interesting. Saw the article Organometallic Elaboration as a Strategy for Tuning the Supramolecular Characteristics of Aza-Crown Ethers published in 2019.0, Reprint Addresses Miller, AJM (corresponding author), Univ N Carolina, Dept Chem, Chapel Hill, NC 27599 USA.. The CAS is 100-83-4. Through research, I have a further understanding and discovery of 3-Hydroxybenzaldehyde.

Outfitting an aza-crown ether with an organotransition-metal pendant provides a mechanism for tuning its supramolecular properties. The binding affinity can be tuned by more than 2 orders of magnitude by changing the identity of the transition metal-center, altering the overall charge of the complex, or engaging in organometallic ligand substitution reactions. High Li+ selectivity (up to 29-fold higher affinity in comparison to Na+), proton-responsive behavior, and ion pair (ditopic) binding capabilities are observed in the metallacrown ethers.

About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Smith, JB; Camp, AM; Farquhar, AH; Kerr, SH; Chen, CH; Miller, AJM or concate me.. SDS of cas: 100-83-4

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Safety of 3-Hydroxybenzaldehyde. Recently I am researching about PROTEIN-KINASE INHIBITORS; DRUG-RESISTANCE; RECEPTOR 2; GROWTH; BENZOTHIAZOLES; ANGIOGENESIS; DISCOVERY; VEGFR-2; POTENT; MECHANISMS, Saw an article supported by the . Published in WILEY-V C H VERLAG GMBH in WEINHEIM ,Authors: Abdel-Mohsen, HT; Abd El-Meguid, EA; El Kerdawy, AM; Mahmoud, AEE; Ali, MM. The CAS is 100-83-4. Through research, I have a further understanding and discovery of 3-Hydroxybenzaldehyde

A novel series of 2-arylbenzothiazoles 9, 10, and 12 were designed and synthesized as VEGFR-2/FGFR-1/PDGFR-beta multiangiokinase inhibitors targeting breast cancer. Structural elongation of the known 2-phenylbenzothiazole scaffold (type I protein kinase inhibitor [PKI]), was carried out to afford series of type II PKIs 9, 10, and 12. Compounds 9d, 9f, 9i, and 9k exhibited potent multikinase inhibitory activity with IC50 values of 0.19, 0.18, 0.17, and 0.13 mu M, respectively, against VEGFR-2; IC50 values of 0.28, 0.37, 0.19, and 0.27 mu M, respectively, against FGFR-1; and IC50 values of 0.07, 0.04, 0.08, and 0.14 mu M, respectively, against PDGFR-beta. Moreover, the synthesized benzothiazoles demonstrated promising cytotoxic activity against the MCF-7 cell line. The most potent benzothiazoles 9d and 9i exhibited IC50 values of 7.83 and 6.58 mu M, respectively, on the MCF-7 cell line in comparison to sorafenib (III), which showed IC50 = 4.33 mu M. Additionally, 9d and 9i showed VEGFR-2 inhibitory activity in MCF-7 cells of 81% and 83% when compared with sorafenib (III), which showed 88% inhibition. Molecular docking of the designed compounds in the VEGFR-2 and FGFR-1 active sites showed the accommodation of the 2-phenylbenzothiazole moiety, as reported, in the hinge region of the receptor tyrosine kinase (RTK)-binding site, while the amide moiety is involved in hydrogen bond interactions with the key amino acids in the gate area; this in turn directs the aryl group to the hydrophobic allosteric back pocket of the RTKs in a type II-like binding mode. The synthesized benzothiazoles showed satisfactory ADME properties for further optimization in drug discovery.

Safety of 3-Hydroxybenzaldehyde. About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Abdel-Mohsen, HT; Abd El-Meguid, EA; El Kerdawy, AM; Mahmoud, AEE; Ali, MM or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Authors Dong, JY; Yue, FY; Wang, XC; Song, HJ; Liu, YX; Wang, QM in AMER CHEMICAL SOC published article about in [Dong, Jianyang; Yue, Fuyang; Wang, Xiaochen; Song, Hongjian; Liu, Yuxiu; Wang, Qingmin] Nankai Univ, Coll Chem, Res Inst Elementoorgan Chem, State Key Lab Elementoorgan Chem, Tianjin 300071, Peoples R China; [Wang, Qingmin] Collaborat Innovat Ctr Chem Sci & Engn Tianjin, Tianjin 300071, Peoples R China in 2020.0, Cited 47.0. COA of Formula: C7H6O2. The Name is 3-Hydroxybenzaldehyde. Through research, I have a further understanding and discovery of 100-83-4

A mild general method for difluoromethylthiolation of aldehydes with PhSO2SCF2H and a decatungstate photocatalyst under redox-neutral conditions has been developed. This reaction is highly efficient, scalable, and oxidant-free. The broad substrate scope and excellent functional group tolerance of the reaction make it suitable for generating libraries of difluoromethyl thioesters. We demonstrated the utility and sustainability of the method by synthesizing several structurally complex difluoromethyl thioesters.

About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Dong, JY; Yue, FY; Wang, XC; Song, HJ; Liu, YX; Wang, QM or concate me.. COA of Formula: C7H6O2

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recently I am researching about EZH2 INHIBITOR 3-DEAZANEPLANOCIN; IN-VITRO EVALUATION; ANTIPROLIFERATIVE ACTIVITY; TUBULIN POLYMERIZATION; DERIVATIVES BEARING; CYTOTOXIC ACTIVITY; CANCER; CARDIOTOXICITY; ANTIOXIDANTS; THERAPY, Saw an article supported by the Hamdard National Foundation (HNF), New Delhi. Published in WILEY-V C H VERLAG GMBH in WEINHEIM ,Authors: Iqbal, MA; Husain, A; Alam, O; Khan, SA; Ahmad, A; Haider, MR; Alam, MA. The CAS is 100-83-4. Through research, I have a further understanding and discovery of 3-Hydroxybenzaldehyde. Category: indole-building-block

In this study, two series of imidazopyridine-linked thiazolidinone rings (5a-hand6a-h) constituting 16 new compounds were synthesized and tested for their antiproliferative activity against a panel of three human cancer cell lines, that is, MCF-7 (human breast cancer), A549 (human lung cancer), and DU145 (human prostate cancer). Three compounds,5h,6f, and6h, exhibited remarkable results against all three cell lines, but compound6hwas found to be the most active one against the breast cancer cell line. Among all the synthesized compounds,6hdisplayed the highest antioxidant results. Furthermore, the potent compounds5h,6f, and6hshowed no signs of toxicity at doses ranging from 50 to 500 mg/kg of animal body weight. The biochemical parameters (SGOT and SGPT) of compound6hnearly matched the control in hepatotoxicity studies. The molecular docking and MM-GBSADG binding studies are in agreement with the in vitro anticancer and antioxidant activity results. The most promising compound6hwas found to have the highest docking score and binding energy, and its absorption, distribution, metabolism, and excretion (ADME) parameters are in the acceptable range. Thus, it can be concluded that6h, an imidazopyridine derivative endowed with a thiazolidinone ring system, has the potential to be developed as an anticancer agent.

Category: indole-building-block. About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Iqbal, MA; Husain, A; Alam, O; Khan, SA; Ahmad, A; Haider, MR; Alam, MA or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recommanded Product: 3-Hydroxybenzaldehyde. Authors Tawfik, EH; Fadda, AA; Soliman, NN; Abou-Zeid, L; Negm, A in WORLD SCI PUBL CO INC published article about in [Tawfik, Eman H.] Taibah Univ, Fac Sci & Arts, Chem Dept, Ulla, Saudi Arabia; [Tawfik, Eman H.; Fadda, Ahmed A.; Soliman, Nanees N.; Negm, Amr] Mansoura Univ, Fac Sci, Chem Dept, Mansoura 35516, Egypt; [Abou-Zeid, Laila] Mansoura Univ, Fac Pharm, Dept Pharmaceut Organ Chem, Mansoura 35516, Egypt in 2019.0, Cited 30.0. The Name is 3-Hydroxybenzaldehyde. Through research, I have a further understanding and discovery of 100-83-4

A new methodology for the synthesis of a new series of mesotetrakis[aryl]-21H,23H-porphyrin derivatives 5a-5d, 6a-6c, 7 and 8 is presented. Structures of new compounds were established based on both elemental and spectral data. Cytotoxicity activity of the newly synthesized compounds was investigated against two human cell lines MCF-7 and HepG2. Molecular docking was performed to investigate the binding between the most active porphyrin derivatives and Bcl-2 molecular biomarkers in HepG2 cells.

Recommanded Product: 3-Hydroxybenzaldehyde. About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Tawfik, EH; Fadda, AA; Soliman, NN; Abou-Zeid, L; Negm, A or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

I found the field of Biochemistry & Molecular Biology; Chemistry very interesting. Saw the article Multifunctional isoxazolidine derivatives as alpha-amylase and alpha-glucosidase inhibitors published in 2020.0. Safety of 3-Hydroxybenzaldehyde, Reprint Addresses Aouadi, K (corresponding author), Univ Monastir, Fac Sci Monastir, Lab Heterocycl Chem Nat Prod & React, Ave Environm, Monastir 5019, Tunisia.. The CAS is 100-83-4. Through research, I have a further understanding and discovery of 3-Hydroxybenzaldehyde

A series of novel isoxazolidines based on benzaldehyde derivatives have been synthesized from the cycloaddition of chiral menthone-based nitrone and allyl phenyl ethers. All synthetic compounds were assessed for their in vitro PPA, HPA and HLAG inhibitory activity. The results revealed that all targets exhibited better inhibitory effect against PPA (12.3 +/- 0.4 < IC50 < 38.2 +/- 0.9 mu M), HPA (10.1 +/- 0.4 < IC50 < 26.8 +/- 0.2 mu M) and HLAG (65.4 +/- 1.2 < IC50 < 274.8 +/- 1.1 mu M) when compared with the reference inhibitor, acarbose (IC50 = 284.6 +/- 0.3 mu M for PPA, 296.6 +/- 0.8 mu M for HPA, 780.4 +/- 0.3 mu M for HLAG) with the highest PPA inhibitory activity was ascribed to compound 3g against both PPA and HPA, and 3b against HLAG enzymes, respectively. Structural activity relationships (SARs) were also established for all synthesized compounds and the interaction modes of the most potent inhibitors (3g for PPA and HPA, 3b for HLAG) and the active site with residues of three enzymes were confirmed through molecular docking studies. Furthermore, a combination of molecular docking analysis with the in vitro activities can help to improve prediction success and encourages the uses of some of these molecules as potential alternatives toward the modulation of T2D. Safety of 3-Hydroxybenzaldehyde. About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Ghabi, A; Brahmi, J; Alminderej, F; Messaoudi, S; Vidal, S; Kadri, A; Aouadi, K or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

I found the field of Chemistry very interesting. Saw the article Structure-Based Design of Dimeric Bisbenzimidazole Inhibitors to an Emergent Trimethoprim-Resistant Type II Dihydrofolate Reductase Guides the Design of Monomeric Analogues published in 2019.0. Safety of 3-Hydroxybenzaldehyde, Reprint Addresses Pelletier, JN (corresponding author), Univ Montreal, Dept Biochim, Montreal, PQ H3C 3J7, Canada.; Pelletier, JN (corresponding author), Univ Montreal, Dept Chim, Montreal, PQ H3C 3J7, Canada.; Pelletier, JN (corresponding author), PROTEO, Quebec Network Res Prot Funct Engn & Applicat, Quebec City, PQ G1V 0A6, Canada.; Pelletier, JN (corresponding author), CGCC, Montreal, PQ H3A 0B8, Canada.. The CAS is 100-83-4. Through research, I have a further understanding and discovery of 3-Hydroxybenzaldehyde

The worldwide use of the broad-spectrum antimicrobial trimethoprim (TMP) has induced the rise of TMP-resistant microorganisms. In addition to resistance-causing mutations of the microbial chromosomal dihydrofolate reductase (Dfr), the evolutionarily and structurally unrelated type II Dfrs (DfrBs) have been identified in TMP-resistant microorganisms. DfrBs are intrinsically TMP-resistant and allow bacterial proliferation when the microbial chromosomal Dfr is TMP-inhibited, making these enzymes important targets for inhibitor development. Furthermore, DfrBs occur in multiresistance plasmids, potentially accelerating their dissemination. We previously reported symmetrical bisbenzimidazoles that are the first selective inhibitors of the only well-characterized DfrB, DfrB1. Here, their diversification provides a new series of inhibitors (K-i = 1.7-12.0 mu M). Our results reveal two prominent features: terminal carboxylates and inhibitor length allow the establishment of essential interactions with DfrB1. Two crystal structures demonstrate the simultaneous binding of two inhibitor molecules in the symmetrical active site. Observations of those dimeric inhibitors inspired the design of monomeric analogues, binding in a single copy yet offering similar inhibition potency (K-i = 1.1 and 7.4 mu M). Inhibition of a second member of the DfrB family, DfrB4, suggests the generality of these inhibitors. These results provide key insights into inhibition of the highly TMP-resistant DfrBs, opening avenues to downstream development of antibiotics for combatting this emergent source of resistance.

About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Toulouse, JL; Yachnin, BJ; Ruediger, EH; Deon, D; Gagnon, M; Saint-Jacques, K; Ebert, MCCJC; Forge, D; Bastien, D; Colin, DY; Eynde, JJV; Marinier, A; Berghuis, AM; Pelletier, JN or concate me.. Safety of 3-Hydroxybenzaldehyde

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles