Category: 100-83-4

An article Introduction of a trinuclear manganese(iii) catalyst on the surface of magnetic cellulose as an eco-benign, efficient and reusable novel heterogeneous catalyst for the multi-component synthesis of new derivatives of xanthene WOS:000612191100006 published article about ONE-POT SYNTHESIS; RECOVERABLE NANO-CATALYST; FACILE SYNTHESIS; IONIC LIQUID; RECYCLABLE CATALYST; NATURAL PHOSPHATE; HIGHLY EFFICIENT; GREEN CHEMISTRY; SULFONIC-ACID; NANOPARTICLES in [Kargar, Pouya Ghamari; Bagherzade, Ghodsieh] Univ Birjand, Fac Sci, Dept Chem, Birjand 97175615, Iran; [Eshghi, Hossein] Ferdowsi Univ Mashhad, Fac Sci, Dept Chem, Mashhad, Razavi Khorasan, Iran in 2021, Cited 77. The Name is 3-Hydroxybenzaldehyde. Through research, I have a further understanding and discovery of 100-83-4. Computed Properties of C7H6O2

In this work, the new trinuclear manganese catalyst defined as Fe3O4@NFC@NNSM-Mn(iii) was successfully manufactured and fully characterized by different techniques, including FT-IR, XRD, TEM, SEM, EDX, VSM, and ICP analysis. There have been reports of the use of magnetic catalysts for the synthesis of xanthine derivatives. The critical potential interest in the present method include short reaction time, high yields, recyclability of the catalyst, easy workup, and the ability to sustain a variety of functional groups, which give economical as well as ecological rewards. Also, the synthesized catalyst was used as a recyclable trinuclear catalyst in alcohol oxidation reactions at 40 degrees C. The magnetic catalyst activity of Fe3O4@NFC@NNSM-Mn(iii) could be attributed to the synergistic effects of the catalyst Fe3O4@NFC@NNS-Mn(iii) with melamine. Employing a sustainable and safe low temperature, using an eco-friendly solvent, no need to use any additive, and long-term stability and magnetic recyclability of the catalyst for at least six successive runs are the advantages of the current protocol towards green chemistry. This protocol is a benign, environmentally friendly method for heterocycle synthesis.

Computed Properties of C7H6O2. About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Kargar, PG; Bagherzade, G; Eshghi, H or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Authors Perez-Nunez, R; Vera-Lopez, JD in ELSEVIER published article about MORTALITY; INJURY; TRENDS in [Perez-Nunez, Ricardo] Inst Nacl Salud Publ, Ctr Invest Sistemas Salud, Cuernavaca, Morelos, Mexico; [Vera-Lopez, Juan Daniel] Secretaria Salud Mexico, Consejo Nacl Prevenc Accidentes, Secretariado Tecn, Ciudad De Mexico, Mexico in 2020.0, Cited 34.0. Recommanded Product: 100-83-4. The Name is 3-Hydroxybenzaldehyde. Through research, I have a further understanding and discovery of 100-83-4

Objective: To characterize the epidemiology of unintentional asphyxias in Mexico from 1999 to 2017. Method: Secondary analysis of vital registries, three national health surveys and information from the safety inspection program of the Ministry of Health in Mexico were used to characterize fatal and non-fatal drownings (ICD-10: W65-W74) and other asphyxias including suffocation, chocking and strangulation (ICD-10: W75-W84), and to estimate the level of exposure to different risk factors within households and daycares. Results: 100,834 deaths were registered, 44.66% were drowning and 77.17% male. Drown ngs mainly affect children and adolescents, occur in April, July and August, on Sundays, during the afternoon. Other asphyxias affect children and the elderly more frequently, occur mainly from December to February, on Sundays and from 4 to 6h. According to ENSANut-2012, 53,065 individuals experience a non-fatal asphyxia per year, 26.21% of them with permanent consequences in their health and wellbeing. Important risks of unintentional asphyxias are present in 38% of daycares and 80% of households analyzed. Conclusions: Unintentional asphyxias are a major public health problem that needs to be urgently attended to achieve the Sustainable Development Goals, in particular the 3.2. Evidence presented in this work constitutes an input to inform and orient efforts directed to tackle this problem. (C) 2019 SESPAS. Published by Elsevier Espana, S.L.U. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

Recommanded Product: 100-83-4. About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Perez-Nunez, R; Vera-Lopez, JD or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Category: indole-building-block. Zhang, Y; Wang, YY; Zhao, YX; Gu, W; Zhu, YQ; Wang, SF in [Zhang, Yan; Wang, Yunyun; Zhao, Yuxun; Gu, Wen; Wang, Shifa] Nanjing Forestry Univ, Coll Chem Engn, Nanjing 210037, Jiangsu, Peoples R China; [Zhu, Yongqiang] Jiangsu Chia Tai Fenghai Pharmaceut Co Ltd, Nanjing 210046, Jiangsu, Peoples R China; [Gu, Wen; Wang, Shifa] Nanjing Forestry Univ, Coinnovat Ctr Efficient Proc & Utilizat Forest Re, Nanjing 210037, Jiangsu, Peoples R China published Novel camphor-based pyrimidine derivatives induced cancer cell death through a ROS-mediated mitochondrial apoptosis pathway in 2019.0, Cited 41.0. The Name is 3-Hydroxybenzaldehyde. Through research, I have a further understanding and discovery of 100-83-4.

A series of novel camphor-based pyrimidine derivatives (3a-3x) have been synthesized; their structures were determined by using conventional methods and compound 3f was further confirmed through single crystal XRD analysis. The cytotoxic activity of the target compounds against a panel of human normal (GES-1) and cancer cell lines (MDA-MB-231, RPMI-8226, A549) was evaluated by MTS assay. Here we found that compound 3f exhibited the strongest anti-tumor activity, comparable to that of etoposide, and had much lower cytotoxicity to normal GES-1 cells (IC50 > 50 mu M) than the reference drug (IC50 = 8.89 mu M). Subsequent mechanism studies in MDA-MB-231 cells revealed that compound 3f caused G0/G1 phase arrest and apoptosis in a dose dependent manner. Moreover, the loss of mitochondrial membrane potential and enhancement of cellular ROS levels were also observed upon 3f treatment, which indicated that 3f exerted cytotoxic activity by a ROS-mediated mitochondrial apoptosis pathway. This result was confirmed by a significant increase in the expression of pro-apoptotic proteins Bax, cytochrome C and caspase-3, and downregulation of anti-apoptosis protein Bcl-2. Overall, 3f can be adopted for further investigation in the development of antitumor agents based on natural products.

Category: indole-building-block. About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Zhang, Y; Wang, YY; Zhao, YX; Gu, W; Zhu, YQ; Wang, SF or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Authors Ghorbani, F; Pourmousavi, SA; Kiyani, H in BENTHAM SCIENCE PUBL LTD published article about ORDERED MESOPOROUS CARBON; SOLVENT-FREE SYNTHESIS; RECYCLABLE CATALYST; SULFONIC-ACID; REUSABLE CATALYST; 1,1-DIACETATES; DEPROTECTION; CHLORIDE; CONVERSION; MILD in [Ghorbani, Fatemeh; Pourmousavi, Seied Ali; Kiyani, Hamzeh] Damghan Univ, Sch Chem, Damghan 3671641167, Iran; [Pourmousavi, Seied Ali] Damghan Univ, Inst Biol Sci, Damghan 3671641167, Iran in 2020.0, Cited 54.0. COA of Formula: C7H6O2. The Name is 3-Hydroxybenzaldehyde. Through research, I have a further understanding and discovery of 100-83-4

Background: Much attention has been focused on heterogeneous catalysts. Reactions with these recoverable and reusable catalysts are clean, selective with high efficiency. Among the heterogeneous solid acid catalyst in organic synthesis, Carbon-Based Solid Acids (CBSAs), which are important solid acid with many practical and research applications have been extensively studied. In this work, green Pistachio peel, a biomass waste, was converted into a novel carbon-based solid acid catalyst (Pis-SO3H). Objective: The aim of this work is to synthesize highly sulfonated carbon as an efficient, recyclable, nontoxic solid acid catalyst by simultaneous sulfonation, dehydration and carbonization of green Pistachio peel as biomass and investigate the catalytic activity of Pis-SO3H in acetalization, thioacetalization, acylation of aldehydes and synthesis of 3,3′-Arylmethylene-bis(4-hydroxycoumarin) derivatives. Methods: Pis-SO3H was synthesized by an integrated fast one- step hydrothermal carbonization and sulfonation process in the presence of sulfuric acid. The characterization of the physicochemical properties of Pis-SO3H was achieved by XRD, FT-IR, FE-SEM, and elemental analysis. Results: The result of acid-base titration showed that the total acidity of the catalyst was 7.75 mmol H(+)g(-1). This new heterogeneous catalyst has been efficiently used for the chemoselective thioacetalization, acetalization and acylation of aldehyde and the synthesis of biscoumarins under solvent-free conditions. All the reactions work easily in high yields. The antimicrobial activity of some of the biscoumarins was evaluated in screening by disk diffusion assay for the zone of inhibition. Conclusion: The catalytic activity of the Pis-SO3H was investigated during acetalization, thioacetalization, acylation and synthesis of biscoumarins. The results of protection of carbonyl groups and synthesis of biscoumarins in the present work offer effective alternatives for environmentally friendly utilization of abundant biomass waste.

About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Ghorbani, F; Pourmousavi, SA; Kiyani, H or concate me.. COA of Formula: C7H6O2

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Synthesis of Homoallylic Alcohols with Acyclic Quaternary Centers through Co-III-Catalyzed Three-Component C-H Bond Addition to Internally Substituted Dienes and Carbonyls WOS:000479782900001 published article about ENANTIOSELECTIVE SYNTHESIS; STEREOGENIC CENTERS; FUNCTIONALIZATION; STEREOCENTERS; SYSTEMS; CONSTRUCTION; ACTIVATION in [Sun Dongbang; Shen, Zican; Ellman, Jonathan A.] Yale Univ, Dept Chem, 225 Prospect St, New Haven, CT 06520 USA in 2019.0, Cited 49.0. Application In Synthesis of 3-Hydroxybenzaldehyde. The Name is 3-Hydroxybenzaldehyde. Through research, I have a further understanding and discovery of 100-83-4

An efficient Co-III-catalyzed three-component strategy to prepare homoallylic alcohols containing acyclic quaternary centers is disclosed. This transformation enables the introduction of two C-C sigma bonds through C-H bond activation and sequential addition to internally substituted dienes and a wide range of aldehydes and activated ketones. Isoprene and other internally monosubstituted dienes are effective inputs, with the reaction proceeding with high diastereoselectivity for those substrate combinations that result in more than one stereogenic center. Moreover, the opposite relative stereochemistry can be achieved by employing 1,2-disubstituted dienes. A mechanism for the transformation is proposed based upon the relative stereochemistry of the products and studies with isotopically labeled starting materials.

Application In Synthesis of 3-Hydroxybenzaldehyde. About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Sun, DB; Shen, ZC; Ellman, JA or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Identification of 4-anilino-6-aminoquinazoline derivatives as potential MERS-CoV inhibitors WOS:000576785800014 published article about RESPIRATORY SYNDROME CORONAVIRUS; DISCOVERY in [Lee, Jun Young; Shin, Young Sup; Kwon, Sunoh; Jin, Young-hee; Jang, Min Seong; Song, Jong Hwan; Kim, Hyoung Rae; Park, Chul Min] Korea Res Inst Chem Technol, Ctr Convergent Res Emerging Virus Infect CEVI, 141 Gajeong Ro, Daejeon 34114, South Korea; [Lee, Jihye; Kim, Seungtaek] Inst Pasteur Korea, Zoonot Virus Lab, Seongnam Si 13488, Gyeonggi Do, South Korea; [Kwon, Sunoh] Korea Inst Oriental Med, Herbal Med Res Div, Daejeon 34054, South Korea; [Jin, Young-hee] Korea Inst Oriental Med, KM Applicat Ctr, Daegu 41062, South Korea; [Jang, Min Seong] Korea Inst Toxicol, Dept Nonclin Studies, Daejeon 34114, South Korea in 2020.0, Cited 19.0. Quality Control of 3-Hydroxybenzaldehyde. The Name is 3-Hydroxybenzaldehyde. Through research, I have a further understanding and discovery of 100-83-4

New therapies for treating coronaviruses are urgently needed. A series of 4-anilino-6-aminoquinazoline derivatives were synthesized and evaluated to show high anti-MERS-CoV activities. N-4-(3-Chloro-4-fluorophenyl)-N-6-(3-methoxybenzyl)quinazoline-4,6-diamine (1) has been identified in a random screen as a hit compound for inhibiting MERS-CoV infection. Throughout optimization process, compound 20 was found to exhibit high inhibitory effect (IC50 = 0.157 mu M, SI = 25) with no cytotoxicity and moderate in vivo PK properties.

About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Lee, JY; Shin, YS; Lee, J; Kwon, S; Jin, YH; Jang, MS; Kim, S; Song, JH; Kim, HR; Park, CM or concate me.. Quality Control of 3-Hydroxybenzaldehyde

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Name: 3-Hydroxybenzaldehyde. Recently I am researching about MIXED-LIGAND COMPLEXES; DNA-DUPLEX; NUCLEOSIDES; OLIGONUCLEOTIDES; PD2+; CYTIDINE; URIDINE; PD(II), Saw an article supported by the European UnionEuropean Commission [721613]; Academy of FinlandAcademy of FinlandEuropean Commission [286478, 294008]. Published in WILEY-V C H VERLAG GMBH in WEINHEIM ,Authors: Maity, S; Hande, M; Lonnberg, T. The CAS is 100-83-4. Through research, I have a further understanding and discovery of 3-Hydroxybenzaldehyde

Oligonucleotides incorporating a central C-nucleoside with either a rigid or flexible benzaldoxime base moiety have been synthesized, and the hybridization properties of their metallacyclic derivatives have been studied by UV melting experiments. In all cases, the metallated duplexes were less stable than their unmetallated counterparts, and the metallacyclic nucleobases did not show a clear preference for any of the canonical nucleobases as a base-pairing partner. With palladated oligonucleotides, increased flexibility translated to less severe destabilization, whereas the opposite was true for the mercurated oligonucleotides; this reflects the greater difficulties in accommodating a rigid Pd-II-mediated base pair than a rigid Hg-II-mediated base pair within the base stack of a double helix.

About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Maity, S; Hande, M; Lonnberg, T or concate me.. Name: 3-Hydroxybenzaldehyde

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

I found the field of Biochemistry & Molecular Biology; Chemistry very interesting. Saw the article Synthesis, anticancer activity and molecular docking studies on 1,2-diarylbenzimidazole analogues as anti-tubulin agents published in 2019.0. Formula: C7H6O2, Reprint Addresses Wang, ZC; Zhu, HL (corresponding author), Nanjing Univ, Sch Life Sci, State Key Lab Pharmaceut Biotechnol, Nanjing 210023, Jiangsu, Peoples R China.; Jiang, AQ (corresponding author), Nanjing Univ, Med Sch, Nanjing 210093, Jiangsu, Peoples R China.. The CAS is 100-83-4. Through research, I have a further understanding and discovery of 3-Hydroxybenzaldehyde

Twenty-four 1,2-diarylbenzimidazole derivatives were designed, synthesized and biologically evaluated. It turned out that most of them were potential anticancer drugs. Among them, compound c24 showed the highest anti-tumor activity (GI(50) = 0.71-2.41 mu M against HeLa, HepG2, A549 and MCF-7 cells), and low toxicity to normal cells (CC50 > 100 mu M against L02 cells). In the microtubule binding assay, c24 showed the most potent inhibition of microtubule polymerization (IC50 = 8.47 mu M). The binding ability of compound c24 to tubulin crystal was verified by molecular docking simulation experiment. Further studies on HepG2 and HeLa cells showed that compound c24 could cause mitotic arrest of tumor cells to G2/M phase then inducing apoptosis. To sum up, compound c24 is a promising microtubule assembly inhibitor.

Formula: C7H6O2. About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Zhang, YL; Yang, R; Xia, LY; Man, RJ; Chu, YC; Jiang, AQ; Wang, ZC; Zhu, HL or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Organic base grafted on magnetic nanoparticles as a recoverable catalyst for the green synthesis of hydropyridine rings WOS:000513235100020 published article about ONE-POT SYNTHESIS; TACRINE-DIHYDROPYRIDINE HYBRIDS; CORE-SHELL NANOPARTICLES; SOLVENT-FREE; POLYHYDROQUINOLINE DERIVATIVES; HANTZSCH 1,4-DIHYDROPYRIDINES; MULTICOMPONENT SYNTHESIS; EFFICIENT; ACID; NANOCATALYSTS in [Bodaghifard, Mohammad Ali] Arak Univ, Fac Sci, Dept Chem, Arak 3815688138, Iran; [Bodaghifard, Mohammad Ali] Arak Univ, Inst Nanosci & Nanotechnol, Arak, Iran in 2020.0, Cited 57.0. The Name is 3-Hydroxybenzaldehyde. Through research, I have a further understanding and discovery of 100-83-4. Name: 3-Hydroxybenzaldehyde

Synthesis of 4-aminiquinaldine grafted on silica-coated nano-Fe3O4 particles (MNPs-AQ) and their performance as a retrievable heterogeneous basic catalyst are disclosed. The catalytic performance of this novel material was studied for the green synthesis of substituted 1,4-dihydropyridine and polyhydroquinoline derivatives via one-pot multicomponent reactions. Eco-friendly method, high yield and purity of the desired products, and short reaction time along with the ease of the work-up procedure outline the advantages of these new methodologies over the earlier ones. The surface and magnetic properties of the core/shell hybrid nanoparticles were characterized via TEM, SEM, XRD, EDS, and FT-IR analysis techniques. This nanocatalyst is recyclable without any deterioration in its catalytic activity.

Name: 3-Hydroxybenzaldehyde. About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Bodaghifard, MA or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Formula: C7H6O2. I found the field of Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science & Technology very interesting. Saw the article Qualitative Chemical Characterization and Multidirectional Biological Investigation of Leaves and Bark Extracts of Anogeissus leiocarpus (DC.) Guill. & Perr. (Combretaceae) published in 2019.0, Reprint Addresses Ferrante, C (corresponding author), Univ G dAnnunzio, Dept Pharm, I-66100 Chieti, Italy.; Zengin, G (corresponding author), Selcuk Univ, Fac Sci, Dept Biol, TR-42130 Konya, Turkey.; Mahomoodally, MF (corresponding author), Univ Mauritius, Fac Sci, Dept Hlth Sci, Reduit 230, Mauritius.. The CAS is 100-83-4. Through research, I have a further understanding and discovery of 3-Hydroxybenzaldehyde.

Anogeissus leiocarpus (DC.) Guill. & Perr. (Combretaceae) has a long history of use by folk populations for the management of multiple human ailments. Based on the published literature, there has been no attempt to conduct a comparative assessment of the biological activity and the phytochemical profiles of the leaves and stem bark of A. leiocarpus extracted using methanol, ethyl acetate, and water. By high-performance liquid chromatography with electrospray ionization mass spectrometric detection (HPLC-ESI-MSn) analysis, quinic, shikimic, gallic, and protocatechuic acids were tentatively identified from all the extracts, while chlorogenic, caffeic, ferulic, and dodecanedioic acids were only characterised from the leaves extracts. Additionally, a pharmacological study was carried out to evaluate potential protective effects that are induced by the extracts in rat colon and colon cancer HCT116 cell line. In general, the methanol and water extracts of A. leiocarpus leaves and stem bark showed potent radical scavenging and reducing properties. It was noted that the stem bark extracts were more potent antioxidants as compared to the leaves extracts. The methanol extract of A. leiocarpus leaves showed the highest acetyl (4.68 mg galantamine equivalent/g) and butyryl (4.0 mg galantamine equivalent/g) cholinesterase inhibition. Among ethyl acetate extracts, the pharmacological investigation suggested stem bark ethyl acetate extracts to be the most promising. This extract revealed ability to protect rat colon from lipopolysaccharide-induced oxidative stress, without exerting promoting effects on HCT116 cell line viability and migration. As a conclusion, A. leiocarpus represents a potential source of bioactive compounds in the development of novel therapeutic agents.

About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Orlando, G; Ferrante, C; Zengin, G; Sinan, KI; Bene, K; Diuzheva, A; Jeko, J; Cziaky, Z; Di Simone, S; Recinella, L; Chiavaroli, A; Leone, S; Brunetti, L; Picot-Allain, CMN; Mahomoodally, MF; Menghini, L or concate me.. Formula: C7H6O2

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles